EP0981642A4 - Kappa b kinase, subunits thereof, and methods of using same - Google Patents
Kappa b kinase, subunits thereof, and methods of using sameInfo
- Publication number
- EP0981642A4 EP0981642A4 EP98908673A EP98908673A EP0981642A4 EP 0981642 A4 EP0981642 A4 EP 0981642A4 EP 98908673 A EP98908673 A EP 98908673A EP 98908673 A EP98908673 A EP 98908673A EP 0981642 A4 EP0981642 A4 EP 0981642A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- kappa
- subunits
- kinase
- methods
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/1101—IkappaB kinase (2.7.11.10)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pulmonology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/810,131 US6268194B1 (en) | 1997-02-25 | 1997-02-25 | IKB kinase and methods of using same |
US810131 | 1997-02-25 | ||
US6147097P | 1997-10-09 | 1997-10-09 | |
US61470P | 1997-10-09 | ||
PCT/US1998/003511 WO1998037228A1 (en) | 1997-02-25 | 1998-02-23 | IλB KINASE, SUBUNITS THEREOF, AND METHODS OF USING SAME |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0981642A1 EP0981642A1 (en) | 2000-03-01 |
EP0981642A4 true EP0981642A4 (en) | 2003-03-19 |
Family
ID=26741107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98908673A Ceased EP0981642A4 (en) | 1997-02-25 | 1998-02-23 | Kappa b kinase, subunits thereof, and methods of using same |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0981642A4 (en) |
JP (2) | JP4125379B2 (en) |
AU (1) | AU740622B2 (en) |
CA (1) | CA2281955C (en) |
WO (1) | WO1998037228A1 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU728679C (en) | 1996-03-19 | 2002-03-21 | Millennium Pharmaceuticals, Inc. | A kinase capable of site-specific phosphorylation of IkBalpha |
US5851812A (en) * | 1997-07-01 | 1998-12-22 | Tularik Inc. | IKK-β proteins, nucleic acids and methods |
US6235512B1 (en) * | 1997-07-01 | 2001-05-22 | Tularik Inc. | IKK-α proteins, nucleic acids and methods |
US6087169A (en) * | 1997-08-04 | 2000-07-11 | Smithkline Beecham Plc | HKABY60: polynucleotide encoding a helix-loop-helix ubiquitous kinase family polypeptide |
EP0897009A3 (en) * | 1997-08-04 | 1999-06-09 | Smithkline Beecham Plc | HKABY60 polypeptides |
US6030834A (en) * | 1997-12-30 | 2000-02-29 | Chiron Corporation | Human IKK-beta DNA constructs and cells |
AU6189999A (en) * | 1998-10-15 | 2000-05-08 | Bioimage A/S | Specific therapeutic interventions obtained by interference with redistribution and/or targetting |
US5977341A (en) * | 1998-11-20 | 1999-11-02 | Isis Pharmaceuticals Inc. | Antisense modulation of inhibitor-kappa B kinase-beta expression |
US5962673A (en) * | 1998-11-20 | 1999-10-05 | Isis Pharmaceuticals Inc. | Antisense modulation of inhibitor-kappa B kinase-alpha expression |
FR2787119A1 (en) * | 1998-12-09 | 2000-06-16 | Inst Nat Sante Rech Med | METHOD FOR SCREENING IN YEAST INHIBITORS OF PROTEIN KINASES SPECIFIC TO HUMAN CELLS AND MAMMALS |
US6630312B2 (en) | 1999-08-10 | 2003-10-07 | Joslin Diabetes Center, Inc. | Method for identifying compounds for treatment of insulin resistance |
AU6898700A (en) | 1999-08-10 | 2001-03-05 | Joslin Diabetes Center Inc. | Method for identifying compounds for treatment of insulin resistance |
US6642215B2 (en) * | 2001-05-24 | 2003-11-04 | Leo Pharma A/S | Method of modulating NF-kB activity |
KR101889140B1 (en) * | 2015-10-12 | 2018-08-17 | 연세대학교 산학협력단 | A Novel Fusion Protein Comprising Transcription Modulation Domain of p65 and Protein Transduction Domain, and Uses Thereof |
CN115819603A (en) * | 2022-12-26 | 2023-03-21 | 广西大学 | Preparation method and application of porcine IKK alpha polyclonal antibody |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998008955A1 (en) * | 1996-08-26 | 1998-03-05 | Signal Pharmaceuticals, Inc. | Stimulus-inducible i (kappa)b kinase [ikk] signalsome |
WO1999001542A1 (en) * | 1997-07-01 | 1999-01-14 | Tularik Inc. | IKK-β PROTEINS, NUCLEIC ACIDS AND METHODS |
EP0897009A2 (en) * | 1997-08-04 | 1999-02-17 | Smithkline Beecham Plc | HKABY60 polypeptides |
-
1998
- 1998-02-23 JP JP53695398A patent/JP4125379B2/en not_active Expired - Fee Related
- 1998-02-23 WO PCT/US1998/003511 patent/WO1998037228A1/en active IP Right Grant
- 1998-02-23 CA CA002281955A patent/CA2281955C/en not_active Expired - Lifetime
- 1998-02-23 AU AU66646/98A patent/AU740622B2/en not_active Expired
- 1998-02-23 EP EP98908673A patent/EP0981642A4/en not_active Ceased
-
2007
- 2007-10-04 JP JP2007260506A patent/JP2008115164A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998008955A1 (en) * | 1996-08-26 | 1998-03-05 | Signal Pharmaceuticals, Inc. | Stimulus-inducible i (kappa)b kinase [ikk] signalsome |
WO1999001542A1 (en) * | 1997-07-01 | 1999-01-14 | Tularik Inc. | IKK-β PROTEINS, NUCLEIC ACIDS AND METHODS |
EP0897009A2 (en) * | 1997-08-04 | 1999-02-17 | Smithkline Beecham Plc | HKABY60 polypeptides |
Non-Patent Citations (4)
Title |
---|
CHEN Z J ET AL: "SITE-SPECIFIC PHOSPHORYLATION OF IKAPPABALPHA BY A NOVEL UBIQUITINATION-DEPENDENT PROTEIN KINASE ACTIVITY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 84, 22 March 1996 (1996-03-22), pages 853 - 862, XP002037788, ISSN: 0092-8674 * |
CONNELLY M A ET AL: "CHUK, A NEW MEMBER OF THE HELIX-LOOP-HELIX AND LEUCINE ZIPPER FAMILIES OF INTERACTING PROTEINS, CONTAINS A SERINE-THREONINE KINASE CATALYTIC DOMAIN", CELLULAR AND MOLECULAR BIOLOGY RESEARCH, vol. 41, no. 6, 1995, pages 537 - 549, XP002914743 * |
REGNIER C H ET AL: "IDENTIFICATION AND CHARACTERIZATION OF AN IKAPPAB KINASE", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 90, no. 2, 25 July 1997 (1997-07-25), pages 373 - 383, XP002053258, ISSN: 0092-8674 * |
See also references of WO9837228A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2008115164A (en) | 2008-05-22 |
JP2001524813A (en) | 2001-12-04 |
EP0981642A1 (en) | 2000-03-01 |
AU6664698A (en) | 1998-09-09 |
AU740622B2 (en) | 2001-11-08 |
CA2281955A1 (en) | 1998-08-27 |
CA2281955C (en) | 2009-09-08 |
WO1998037228A1 (en) | 1998-08-27 |
JP4125379B2 (en) | 2008-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0608897A3 (en) | Tyrosine kinase inhibitors and benzoylacrylamide derivatives. | |
ZA986905B (en) | Substituted quinazoline derivatives. | |
GB9607729D0 (en) | Quinazoline derivatives | |
ZA962522B (en) | Quinazoline derivatives. | |
NO980682D0 (en) | Appliance deployment and method | |
ZA9610725B (en) | Tyrosine derivatives | |
GB9717766D0 (en) | Methods | |
HUP9900163A3 (en) | Process for the preparation of sterol-and stanol-esters, and use thereof | |
EP0981642A4 (en) | Kappa b kinase, subunits thereof, and methods of using same | |
GB2346823B (en) | Reamer and method of using the same | |
DE59804842D1 (en) | Aliphatische, emissionsarme, sinterfähige thermoplastische polyurethanformmassen | |
GB9708918D0 (en) | Methods | |
PL354994A1 (en) | Bio-supportive matrices, methods of making and using the same | |
PL345068A1 (en) | Novel compounds derived from α-d-xylose, preparation method and therapeutic use | |
ZA985326B (en) | Aminospiropiperidine quinazoline derivatives | |
EP0854920A4 (en) | Mouse integrin subunits | |
PL321482A1 (en) | Method of obtaining 2,6-bis/picrylamino/3,4-dinitrilpyridine | |
GB9708412D0 (en) | An umbrella | |
PL321484A1 (en) | Method of obtaining 2,6-bis/picrylamino/3,4-dinitrilpyridine | |
ZA987649B (en) | Imidazoquinoxaline protein tyrosine kinase inhibitors. | |
PL325306A1 (en) | Epoxyazetidiones, method of obtaining them and their application | |
PL321483A1 (en) | Method of obtaining 2,6-bis/picrylamino/3,4-dinitrilpyridine | |
ZA986485B (en) | Levobupivacaine and its use. | |
IL149331A0 (en) | Bio-supportive matrices, methods of making and using the same | |
PL336473A1 (en) | Method of obtaining 1,4,7,10-tetrazacyclodekane |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990921 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ZANDI, EBRAHIM, USC NORRIS COMP.CANCER CENTER Inventor name: HAYAKAWA, MAKIO Inventor name: ROTHWARF, DAVID, M. Inventor name: DIDONATO, JOSEPH, A. Inventor name: KARIN, MICHAEL |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030131 |
|
17Q | First examination report despatched |
Effective date: 20031219 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 20080208 |