EP0964694A4 - Mucin-mediated immunomodulation - Google Patents

Mucin-mediated immunomodulation

Info

Publication number
EP0964694A4
EP0964694A4 EP97946409A EP97946409A EP0964694A4 EP 0964694 A4 EP0964694 A4 EP 0964694A4 EP 97946409 A EP97946409 A EP 97946409A EP 97946409 A EP97946409 A EP 97946409A EP 0964694 A4 EP0964694 A4 EP 0964694A4
Authority
EP
European Patent Office
Prior art keywords
mucin
mediated immunomodulation
immunomodulation
mediated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97946409A
Other languages
German (de)
French (fr)
Other versions
EP0964694A1 (en
Inventor
Jianlin Gong
Donald Kufe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of EP0964694A1 publication Critical patent/EP0964694A1/en
Publication of EP0964694A4 publication Critical patent/EP0964694A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
EP97946409A 1996-10-25 1997-10-24 Mucin-mediated immunomodulation Withdrawn EP0964694A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73826296A 1996-10-25 1996-10-25
US738262 1996-10-25
PCT/US1997/019784 WO1998017300A1 (en) 1996-10-25 1997-10-24 Mucin-mediated immunomodulation

Publications (2)

Publication Number Publication Date
EP0964694A1 EP0964694A1 (en) 1999-12-22
EP0964694A4 true EP0964694A4 (en) 2000-09-13

Family

ID=24967271

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97946409A Withdrawn EP0964694A4 (en) 1996-10-25 1997-10-24 Mucin-mediated immunomodulation

Country Status (4)

Country Link
EP (1) EP0964694A4 (en)
JP (1) JP2001502907A (en)
CA (1) CA2269349A1 (en)
WO (1) WO1998017300A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010783A1 (en) * 1996-09-10 1998-03-19 Biomira Inc. Muc-1 as an immunosuppressive therapeutic agent for the treatment of inflammatory and autoimmune conditions
US20050169898A1 (en) 1997-04-15 2005-08-04 Jianlin Gong Cell fusions and methods of making and using the same
WO1998046785A1 (en) * 1997-04-15 1998-10-22 Dana-Farber Cancer Institute, Inc. Dendritic cell hybrids
GB9904695D0 (en) * 1999-03-01 1999-04-21 Imp Cancer Res Tech Peptide
US8031190B2 (en) 2004-05-03 2011-10-04 Microsoft Corporation Translating two-dimensional user input on three-dimensional scene

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005054A1 (en) * 1987-01-07 1988-07-14 Imperial Cancer Research Technology Limited Probe
WO1995003825A1 (en) * 1993-07-30 1995-02-09 Finn Olivera J Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
WO1998010783A1 (en) * 1996-09-10 1998-03-19 Biomira Inc. Muc-1 as an immunosuppressive therapeutic agent for the treatment of inflammatory and autoimmune conditions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005054A1 (en) * 1987-01-07 1988-07-14 Imperial Cancer Research Technology Limited Probe
WO1995003825A1 (en) * 1993-07-30 1995-02-09 Finn Olivera J Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
WO1998010783A1 (en) * 1996-09-10 1998-03-19 Biomira Inc. Muc-1 as an immunosuppressive therapeutic agent for the treatment of inflammatory and autoimmune conditions

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DENTON G ET AL: "INDUCTION OF ANTIBODY RESPONSES TO BREAST CARCINOMA ASSOCIATED MUCINS USING SYNTHETIC PEPTIDE CONSTRUCTS AS IMMUNOGENS", CANCER LETTERS,US,NEW YORK, NY, vol. 70, no. 3, 16 July 1993 (1993-07-16), pages 143 - 150, XP002035983, ISSN: 0304-3835 *
GRAHAM R A ET AL: "The polymorphic epithelial mucin: potential as an immunogen for a cancer vaccine", CANCER IMMUNOLOGY AND IMMUNOTHERAPY,DE,BERLIN, vol. 2, no. 42, 1 January 1996 (1996-01-01), pages 71 - 80, XP002075466, ISSN: 0340-7004 *
HILKENS J ET AL: "Is episialin/MUC1 involved in breast cancer progression?", CANCER LETTERS, vol. 90, no. 1, 1995, pages 27 - 33, XP000915262, ISSN: 0304-3835 *
PEAT N ET AL: "TISSUE-SPECIFIC EXPRESSION OF A HUMAN POLYMORPHIC EPITHELIAL MUCIN MUC1 IN TRANSGENIC MICE", CANCER RESEARCH, vol. 52, no. 7, 1992, pages 1954 - 1960, XP000915268, ISSN: 0008-5472 *
REDDISH MARK A ET AL: "Pre-immunotherapy serum CA27.29 (MUC-1) mucin level and CD69+ lymphocytes correlate with effects of Theratope sialyl-Tn-KLH cancer vaccine in active specific immunotherapy.", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 42, no. 5, 1996, pages 303 - 309, XP000914873, ISSN: 0340-7004 *
See also references of WO9817300A1 *
VAN DE WIEL-VAN KEMENADE ELLY ET AL: "Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction.", JOURNAL OF IMMUNOLOGY, vol. 151, no. 2, 1993, pages 767 - 776, XP002141253, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
JP2001502907A (en) 2001-03-06
CA2269349A1 (en) 1998-04-30
EP0964694A1 (en) 1999-12-22
WO1998017300A1 (en) 1998-04-30

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