EP0961614A4 - Tricarboxylic acid-containing oxyalkyl esters and uses thereof - Google Patents

Tricarboxylic acid-containing oxyalkyl esters and uses thereof

Info

Publication number
EP0961614A4
EP0961614A4 EP97952599A EP97952599A EP0961614A4 EP 0961614 A4 EP0961614 A4 EP 0961614A4 EP 97952599 A EP97952599 A EP 97952599A EP 97952599 A EP97952599 A EP 97952599A EP 0961614 A4 EP0961614 A4 EP 0961614A4
Authority
EP
European Patent Office
Prior art keywords
tricarboxylic acid
containing oxyalkyl
oxyalkyl esters
esters
tricarboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97952599A
Other languages
German (de)
French (fr)
Other versions
EP0961614A1 (en
Inventor
Abraham Nudelman
Ada Rephaeli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bar Ilan University
Mor Research Applications Ltd
Original Assignee
Bar Ilan University
Mor Research Applications Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/781,905 external-priority patent/US6130248A/en
Application filed by Bar Ilan University, Mor Research Applications Ltd filed Critical Bar Ilan University
Publication of EP0961614A1 publication Critical patent/EP0961614A1/en
Publication of EP0961614A4 publication Critical patent/EP0961614A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/42—Glutaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP97952599A 1996-12-30 1997-12-30 Tricarboxylic acid-containing oxyalkyl esters and uses thereof Withdrawn EP0961614A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US781905 1985-09-30
US08/781,905 US6130248A (en) 1996-12-30 1996-12-30 Tricarboxylic acid-containing oxyalkyl esters and uses thereof
US81436597A 1997-03-11 1997-03-11
US814365 1997-03-11
PCT/US1997/023725 WO1998029114A1 (en) 1996-12-30 1997-12-30 Tricarboxylic acid-containing oxyalkyl esters and uses thereof

Publications (2)

Publication Number Publication Date
EP0961614A1 EP0961614A1 (en) 1999-12-08
EP0961614A4 true EP0961614A4 (en) 2002-07-24

Family

ID=27119918

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97952599A Withdrawn EP0961614A4 (en) 1996-12-30 1997-12-30 Tricarboxylic acid-containing oxyalkyl esters and uses thereof

Country Status (3)

Country Link
EP (1) EP0961614A4 (en)
AU (1) AU5617398A (en)
WO (1) WO1998029114A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228362B1 (en) 1992-08-21 2001-05-08 Immunomedics, Inc. Boron neutron capture therapy using pre-targeting methods
AU7993500A (en) * 1999-11-15 2001-05-30 New Millennium Pharmaceutical Research, Inc. Intranasal administration of raloxifene and tamoxifen
EP1170008A1 (en) * 2000-07-07 2002-01-09 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Valproic acid and derivatives thereof as histone deacetylase inhibitors
AUPR059400A0 (en) * 2000-10-06 2000-11-02 Bar-Ilan University Formaldehyde-releasing prodrugs
US6562995B1 (en) * 2000-12-21 2003-05-13 Beacon Laboratories, Inc. Delta dicarbonyl compounds and methods for using the same
US7732475B2 (en) 2005-07-14 2010-06-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
CA2806444C (en) * 2008-08-19 2016-02-23 Xenoport, Inc. Prodrugs of methyl hydrogen fumarate
CA2882713A1 (en) * 2012-08-22 2014-02-27 Xenoport, Inc. Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
JP2015526476A (en) 2012-08-22 2015-09-10 ゼノポート，インコーポレイティド Oral dosage form of methylhydrogen fumarate and its prodrug
ES2683355T3 (en) 2013-03-14 2018-09-26 Alkermes Pharma Ireland Limited Prodrugs of smokers and their use in the treatment of various diseases
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
US9302977B2 (en) 2013-06-07 2016-04-05 Xenoport, Inc. Method of making monomethyl fumarate
US9421182B2 (en) 2013-06-21 2016-08-23 Xenoport, Inc. Cocrystals of dimethyl fumarate
WO2015035184A1 (en) 2013-09-06 2015-03-12 Xenoport, Inc. Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use
NZ723269A (en) 2014-02-24 2017-04-28 Alkermes Pharma Ireland Ltd Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
WO2017060422A1 (en) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected carboxylic acid-based metabolites for the treatment of mitochondrial disorders
WO2017060418A1 (en) * 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected carboxylic acid-based metabolites for the treatment of mitochondria-related diseases
LT3762368T (en) 2018-03-08 2022-06-10 Incyte Corporation Aminopyrazine diol compounds as pi3k-y inhibitors
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462934A (en) * 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
EP0276942A1 (en) * 1987-01-27 1988-08-03 Pfizer Inc. 6-Beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof
JPH06192273A (en) * 1992-10-26 1994-07-12 Lederle Japan Ltd Carbapenem-3-carboxylic ester derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462934A (en) * 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
EP0276942A1 (en) * 1987-01-27 1988-08-03 Pfizer Inc. 6-Beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof
JPH06192273A (en) * 1992-10-26 1994-07-12 Lederle Japan Ltd Carbapenem-3-carboxylic ester derivative

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent World Patents Index; *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 542 (C - 1261) 17 October 1994 (1994-10-17) *
See also references of WO9829114A1 *

Also Published As

Publication number Publication date
EP0961614A1 (en) 1999-12-08
WO1998029114A1 (en) 1998-07-09
AU5617398A (en) 1998-07-31

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