EP0960208A4 - Glutathione s-transferase (gst) genes in cancer - Google Patents

Glutathione s-transferase (gst) genes in cancer

Info

Publication number
EP0960208A4
EP0960208A4 EP97953034A EP97953034A EP0960208A4 EP 0960208 A4 EP0960208 A4 EP 0960208A4 EP 97953034 A EP97953034 A EP 97953034A EP 97953034 A EP97953034 A EP 97953034A EP 0960208 A4 EP0960208 A4 EP 0960208A4
Authority
EP
European Patent Office
Prior art keywords
gst
glutathione
transferase
genes
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97953034A
Other languages
German (de)
French (fr)
Other versions
EP0960208A1 (en
Inventor
Francis Ali-Osman
Gabriel Lopez-Berestein
John K Buolamwini
Gamil Antoun
Hui-Wen Lo
Charles Keller
Olanike Akande
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Mississippi
University of Texas System
Original Assignee
University of Mississippi
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Mississippi, University of Texas System filed Critical University of Mississippi
Publication of EP0960208A1 publication Critical patent/EP0960208A1/en
Publication of EP0960208A4 publication Critical patent/EP0960208A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP97953034A 1996-11-12 1997-11-12 Glutathione s-transferase (gst) genes in cancer Withdrawn EP0960208A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US747536 1996-11-12
US08/747,536 US5968737A (en) 1996-11-12 1996-11-12 Method of identifying inhibitors of glutathione S-transferase (GST) gene expression
PCT/US1997/020987 WO1998021359A1 (en) 1996-11-12 1997-11-12 Glutathione s-transferase (gst) genes in cancer

Publications (2)

Publication Number Publication Date
EP0960208A1 EP0960208A1 (en) 1999-12-01
EP0960208A4 true EP0960208A4 (en) 2002-10-30

Family

ID=25005507

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97953034A Withdrawn EP0960208A4 (en) 1996-11-12 1997-11-12 Glutathione s-transferase (gst) genes in cancer

Country Status (5)

Country Link
US (1) US5968737A (en)
EP (1) EP0960208A4 (en)
JP (1) JP2001504340A (en)
CA (1) CA2270910A1 (en)
WO (1) WO1998021359A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956568A1 (en) * 1999-01-30 2000-08-17 Roland Kreutzer Method and medicament for inhibiting the expression of a given gene
AU1760001A (en) * 1999-11-10 2001-06-06 Quest Diagnostics Investments Incorporated Use of computationally derived protein structures of genetic polymorphisms in pharmacogenomics and clinical applications
US20060141480A1 (en) * 1999-11-10 2006-06-29 Kalyanaraman Ramnarayan Use of computationally derived protein structures of genetic polymorphisms in pharmacogenomics and clinical applications
US7829693B2 (en) * 1999-11-24 2010-11-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
WO2002027324A2 (en) * 2000-09-28 2002-04-04 Millennium Pharmaceuticals, Inc. METHODS OF USE OF ALPHA-METHYLACYL-CoA RACEMASE IN HORMONE REFRACTORY AND METASTATIC PROSTATE CANCERS
US8546143B2 (en) 2001-01-09 2013-10-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a target gene
US6686155B2 (en) * 2001-06-14 2004-02-03 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression
IL159926A0 (en) * 2001-08-06 2004-06-20 Pharmacia Italia Spa Aminoisoxazole derivatives active as kinase inhibitors
WO2003105783A2 (en) * 2002-06-12 2003-12-24 Avalon Pharmaceuticals, Inc. Cancer-linked gene as target for chemotherapy
ES2340766T3 (en) * 2002-11-12 2010-06-09 Grunenthal Gmbh DERIVATIVES OF 4-HYDROXIMETHYL-1-ARIL-CYCLOHEXILAMINE
US20040121413A1 (en) * 2002-12-20 2004-06-24 Aebersold Rudolf H. Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions
WO2006113679A2 (en) 2005-04-15 2006-10-26 Board Of Regents, The University Of Texas System Delivery of sirna by neutral lipid compositions
US20070154963A1 (en) * 2005-12-30 2007-07-05 Danying Cai Method to determine whether a compound is a cellular GSTpi inhibitor
PL2493496T3 (en) 2009-10-30 2017-03-31 Medizinische Universität Wien Use of gstp1
US8557532B2 (en) 2010-08-30 2013-10-15 The University Of Utah Research Foundation Diagnosis and treatment of drug-resistant Ewing'S sarcoma
US9340584B2 (en) 2011-03-29 2016-05-17 The General Hospital Corporation Engineered thioredoxin-like fold proteins
US20180002702A1 (en) 2014-12-26 2018-01-04 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
US11045488B2 (en) 2014-12-26 2021-06-29 Nitto Denko Corporation RNA interference agents for GST-π gene modulation
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
US10792299B2 (en) 2014-12-26 2020-10-06 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
US20160187319A1 (en) * 2014-12-26 2016-06-30 Nitto Denko Corporation Cell death-inducing agent, cell growth-inhibiting agent, and pharmaceutical composition for treatment of disease caused by abnormal cell growth
CN109564151B (en) 2016-03-17 2023-01-24 贝克顿·迪金森公司 Cell sorting using high throughput fluorescence flow cytometer
WO2019030718A1 (en) * 2017-08-11 2019-02-14 Glaxosmithkline Biologicals Sa Rna identity method using rnase h digestion and size fractionating
MX2019001389A (en) * 2019-01-31 2020-02-20 Atso Corp Affairs S A De C V Anti-sense oligonucleotides of glutathione s transferase for cancer treatment.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006293A1 (en) * 1993-08-25 1995-03-02 Symbicom Aktiebolag Molecular modelling and drug design
WO1996024902A1 (en) * 1995-02-08 1996-08-15 Wertz David H System and method for molecular modeling

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006293A1 (en) * 1993-08-25 1995-03-02 Symbicom Aktiebolag Molecular modelling and drug design
WO1996024902A1 (en) * 1995-02-08 1996-08-15 Wertz David H System and method for molecular modeling

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] EBI; 12 July 1988 (1988-07-12), KANO ET AL: "Human mRNA for class Pi glutathione S-transferase.", XP002211836, retrieved from EMBL Database accession no. x06547 *
DATABASE EMBL [online] EBI; 23 May 1995 (1995-05-23), LO ET AL: "Human glutathione S-transferase-P1c gene, complete cds", XP002211835, retrieved from EMBL Database accession no. U21689 *
See also references of WO9821359A1 *

Also Published As

Publication number Publication date
US5968737A (en) 1999-10-19
CA2270910A1 (en) 1998-05-22
EP0960208A1 (en) 1999-12-01
JP2001504340A (en) 2001-04-03
WO1998021359A1 (en) 1998-05-22

Similar Documents

Publication Publication Date Title
EP0960208A4 (en) Glutathione s-transferase (gst) genes in cancer
EG21363A (en) Data store
GB2322045B (en) Data store
EP0981656A4 (en) Low resistivity w using b 2?h 6?
GB9707213D0 (en) Improvement in satellite position determination
SG60152A1 (en) Polycarbonate/abs blends
AU5340699A (en) Human anion transporter genes atnov
GB9618638D0 (en) Improvements in underwater ploughing
GB2331582A8 (en) Multi angle spirit level
GB2354522B (en) DAP-kinase related protein
GB9719099D0 (en) Albums
GB9603033D0 (en) Artifial rocks
AU3613697A (en) Forwardly located bit retention means
AUPO135196A0 (en) Forwardly located bit retention means
CA80605S (en) Boat
AUPO696097A0 (en) Resiliently held surfboard holder
GB9727347D0 (en) Cancer
TW325217U (en) Dust-proof humidity-proof isolated radiator
PL57804Y1 (en) Angle shape
GB9723412D0 (en) Cancer gene
AU132452S (en) Surfboard holder
PL58171Y1 (en) Radiator
GB9621675D0 (en) Multi purpose self-lam market
GB9713274D0 (en) Complete rear view
HU946U (en) Data carrying means

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990607

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20020918

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 20031106

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20041019