EP0960208A4 - Glutathione s-transferase (gst) genes in cancer - Google Patents
Glutathione s-transferase (gst) genes in cancerInfo
- Publication number
- EP0960208A4 EP0960208A4 EP97953034A EP97953034A EP0960208A4 EP 0960208 A4 EP0960208 A4 EP 0960208A4 EP 97953034 A EP97953034 A EP 97953034A EP 97953034 A EP97953034 A EP 97953034A EP 0960208 A4 EP0960208 A4 EP 0960208A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- gst
- glutathione
- transferase
- genes
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108010070675 Glutathione transferase Proteins 0.000 title 1
- 102000005720 Glutathione transferase Human genes 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/747,536 US5968737A (en) | 1996-11-12 | 1996-11-12 | Method of identifying inhibitors of glutathione S-transferase (GST) gene expression |
US747536 | 1996-11-12 | ||
PCT/US1997/020987 WO1998021359A1 (en) | 1996-11-12 | 1997-11-12 | Glutathione s-transferase (gst) genes in cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0960208A1 EP0960208A1 (en) | 1999-12-01 |
EP0960208A4 true EP0960208A4 (en) | 2002-10-30 |
Family
ID=25005507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97953034A Withdrawn EP0960208A4 (en) | 1996-11-12 | 1997-11-12 | Glutathione s-transferase (gst) genes in cancer |
Country Status (5)
Country | Link |
---|---|
US (1) | US5968737A (en) |
EP (1) | EP0960208A4 (en) |
JP (1) | JP2001504340A (en) |
CA (1) | CA2270910A1 (en) |
WO (1) | WO1998021359A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19956568A1 (en) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Method and medicament for inhibiting the expression of a given gene |
AU1760001A (en) * | 1999-11-10 | 2001-06-06 | Quest Diagnostics Investments Incorporated | Use of computationally derived protein structures of genetic polymorphisms in pharmacogenomics and clinical applications |
US20060141480A1 (en) * | 1999-11-10 | 2006-06-29 | Kalyanaraman Ramnarayan | Use of computationally derived protein structures of genetic polymorphisms in pharmacogenomics and clinical applications |
US7829693B2 (en) * | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
WO2002027324A2 (en) * | 2000-09-28 | 2002-04-04 | Millennium Pharmaceuticals, Inc. | METHODS OF USE OF ALPHA-METHYLACYL-CoA RACEMASE IN HORMONE REFRACTORY AND METASTATIC PROSTATE CANCERS |
US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
US6686155B2 (en) * | 2001-06-14 | 2004-02-03 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression |
BR0211742A (en) * | 2001-08-06 | 2004-08-24 | Pharmacia Italia Spa | Active Aminoisoxazole Derivatives as Kinase Inhibitors |
AU2003247564A1 (en) * | 2002-06-12 | 2003-12-31 | Avalon Pharmaceuticals, Inc. | Cancer-linked gene as target for chemotherapy |
AU2003296564A1 (en) * | 2002-11-12 | 2004-06-03 | Grunenthal Gmbh | 4-hydroxymethyl-1-aryl-cyclohexylamine derivatives |
US20040121413A1 (en) * | 2002-12-20 | 2004-06-24 | Aebersold Rudolf H. | Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions |
AU2006236453B2 (en) | 2005-01-25 | 2012-02-23 | Board Of Regents, The University Of Texas System | Delivery of siRNA by neutral lipid compositions |
US20070154963A1 (en) * | 2005-12-30 | 2007-07-05 | Danying Cai | Method to determine whether a compound is a cellular GSTpi inhibitor |
WO2011050379A1 (en) | 2009-10-30 | 2011-05-05 | Medizinische Universität Wien | Use of gstp1 |
US8557532B2 (en) | 2010-08-30 | 2013-10-15 | The University Of Utah Research Foundation | Diagnosis and treatment of drug-resistant Ewing'S sarcoma |
US9340584B2 (en) | 2011-03-29 | 2016-05-17 | The General Hospital Corporation | Engineered thioredoxin-like fold proteins |
US11045488B2 (en) | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
US20180002702A1 (en) | 2014-12-26 | 2018-01-04 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
US10792299B2 (en) | 2014-12-26 | 2020-10-06 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
US20160187319A1 (en) * | 2014-12-26 | 2016-06-30 | Nitto Denko Corporation | Cell death-inducing agent, cell growth-inhibiting agent, and pharmaceutical composition for treatment of disease caused by abnormal cell growth |
EP3430376A1 (en) | 2016-03-17 | 2019-01-23 | BD Biosciences | Cell sorting using a high throughput fluorescence flow cytometer |
EP3665306B1 (en) * | 2017-08-11 | 2022-10-19 | GlaxoSmithKline Biologicals SA | Rna identity method using rnase h digestion and size fractionating |
MX2019001389A (en) * | 2019-01-31 | 2020-02-20 | Atso Corp Affairs S A De C V | Anti-sense oligonucleotides of glutathione s transferase for cancer treatment. |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995006293A1 (en) * | 1993-08-25 | 1995-03-02 | Symbicom Aktiebolag | Molecular modelling and drug design |
WO1996024902A1 (en) * | 1995-02-08 | 1996-08-15 | Wertz David H | System and method for molecular modeling |
-
1996
- 1996-11-12 US US08/747,536 patent/US5968737A/en not_active Expired - Fee Related
-
1997
- 1997-11-12 EP EP97953034A patent/EP0960208A4/en not_active Withdrawn
- 1997-11-12 JP JP52289498A patent/JP2001504340A/en active Pending
- 1997-11-12 WO PCT/US1997/020987 patent/WO1998021359A1/en not_active Application Discontinuation
- 1997-11-12 CA CA002270910A patent/CA2270910A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995006293A1 (en) * | 1993-08-25 | 1995-03-02 | Symbicom Aktiebolag | Molecular modelling and drug design |
WO1996024902A1 (en) * | 1995-02-08 | 1996-08-15 | Wertz David H | System and method for molecular modeling |
Non-Patent Citations (3)
Title |
---|
DATABASE EMBL [online] EBI; 12 July 1988 (1988-07-12), KANO ET AL: "Human mRNA for class Pi glutathione S-transferase.", XP002211836, retrieved from EMBL Database accession no. x06547 * |
DATABASE EMBL [online] EBI; 23 May 1995 (1995-05-23), LO ET AL: "Human glutathione S-transferase-P1c gene, complete cds", XP002211835, retrieved from EMBL Database accession no. U21689 * |
See also references of WO9821359A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2001504340A (en) | 2001-04-03 |
WO1998021359A1 (en) | 1998-05-22 |
EP0960208A1 (en) | 1999-12-01 |
US5968737A (en) | 1999-10-19 |
CA2270910A1 (en) | 1998-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990607 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020918 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20031106 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20041019 |