EP0957916A4 - Methods and compositions for treating urinary incontinence using enantiomerically enriched (r)-clidinium - Google Patents

Methods and compositions for treating urinary incontinence using enantiomerically enriched (r)-clidinium

Info

Publication number
EP0957916A4
EP0957916A4 EP97932349A EP97932349A EP0957916A4 EP 0957916 A4 EP0957916 A4 EP 0957916A4 EP 97932349 A EP97932349 A EP 97932349A EP 97932349 A EP97932349 A EP 97932349A EP 0957916 A4 EP0957916 A4 EP 0957916A4
Authority
EP
European Patent Office
Prior art keywords
clidinium
compositions
methods
urinary incontinence
enantiomerically enriched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97932349A
Other languages
German (de)
French (fr)
Other versions
EP0957916A1 (en
Inventor
Vincent L Fabiano
John R Mccullough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of EP0957916A1 publication Critical patent/EP0957916A1/en
Publication of EP0957916A4 publication Critical patent/EP0957916A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
EP97932349A 1996-07-01 1997-06-27 Methods and compositions for treating urinary incontinence using enantiomerically enriched (r)-clidinium Withdrawn EP0957916A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2073096P 1996-07-01 1996-07-01
US20730P 1996-07-01
PCT/US1997/011258 WO1998000138A1 (en) 1996-07-01 1997-06-27 Methods and compositions for treating urinary incontinence using enantiomerically enriched (r)-clidinium

Publications (2)

Publication Number Publication Date
EP0957916A1 EP0957916A1 (en) 1999-11-24
EP0957916A4 true EP0957916A4 (en) 2000-02-23

Family

ID=21800231

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97932349A Withdrawn EP0957916A4 (en) 1996-07-01 1997-06-27 Methods and compositions for treating urinary incontinence using enantiomerically enriched (r)-clidinium

Country Status (2)

Country Link
EP (1) EP0957916A4 (en)
WO (1) WO1998000138A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482837B1 (en) * 1998-04-24 2002-11-19 University Of Rochester Antimuscarinic compounds and methods for treatment of bladder diseases
WO2004064789A2 (en) 2003-01-16 2004-08-05 University Of Rochester Quaternary antimuscarinic compounds for the treatment of bladder diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
US4644003A (en) * 1985-04-03 1987-02-17 Research Corporation 3-quinuclidinol esters, useful as antagonists of muscarinic acetylcholine receptors
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
HAURI D.: "[Incontinence of urine: Possibilities for pharmacotherapy].", MEDIZINISCHE MONATSSCHRIFT FUR PHARMAZEUTEN, (1984) 7/8 (233-239). CODEN: MMPHDB, XP000863460 *
KOPPENHOEFER B. ET AL: "Separation of enantiomers of drugs by capillary electrophoresis I..gamma.-Cyclodextrin as chiral solvating agent.", JOURNAL OF CHROMATOGRAPHY A, (1995) 717/1-2 (181-190)., XP000605057 *
KOPPENHOEFER, BERNHARD ET AL: "Separation of enantiomers of drugs by capillary electrophoresis Part 4: hydroxypropyl-gamma-cyclodextrin as chiral solvating agent", ELECTROPHORESIS (1997), 18(6), 924-930, XP000863400 *
LIN B C (REPRINT) ET AL: "SEPARATION OF DRUG ENANTIOMERS BY CAPILLARY ELECTROPHORESIS ALPHA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT", CHROMATOGRAPHIA, (JAN 1996) VOL. 42, NO. 1-2, PP. 106-110. ISSN: 0009-5893., vol. 42, no. 1/2, 1996, DALIAN INST CHEM PHYS, ZHONG SHAN RD 161, DALIAN 116012, PEOPLES R CHINA (Reprint);CHINA PHARMACEUT UNIV, NANJING 250009, PEOPLES R CHINA; UNIV TUBINGEN, INST ORGAN CHEM, D-72076 TUBINGEN, GERMANY, pages 106 - 110, XP000863359 *
LIN, BINGCHENG ET AL: "Investigation of 123 chiral drugs by cyclodextrin-modified capillary electrophoresis", LC-GC (1997), 15(1), 40, 44-46, XP000863469 *
See also references of WO9800138A1 *
YURDAKOK M ET AL: "Treatment of enuresis: a study with imipramine, amitriptyline, chlordiazepoxide- clidinium and piracetam.", TURKISH JOURNAL OF PEDIATRICS, (1986 JUL-SEP) 28 (3) 171-5., XP000863478 *

Also Published As

Publication number Publication date
WO1998000138A1 (en) 1998-01-08
EP0957916A1 (en) 1999-11-24

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