EP0957769A1 - Apparatus for ultrasonic tissue investigation - Google Patents

Apparatus for ultrasonic tissue investigation

Info

Publication number
EP0957769A1
EP0957769A1 EP96905953A EP96905953A EP0957769A1 EP 0957769 A1 EP0957769 A1 EP 0957769A1 EP 96905953 A EP96905953 A EP 96905953A EP 96905953 A EP96905953 A EP 96905953A EP 0957769 A1 EP0957769 A1 EP 0957769A1
Authority
EP
European Patent Office
Prior art keywords
tissue
signals
area
pulse
visual image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP96905953A
Other languages
German (de)
French (fr)
Other versions
EP0957769B1 (en
EP0957769B9 (en
Inventor
Mary Dyson
Hugh Lewis
Stephen Robert Young
John Andrew Lynch
Walter Raymond Dyson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quality Medical Instruments Ltd
Original Assignee
Quality Medical Instruments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quality Medical Instruments Ltd filed Critical Quality Medical Instruments Ltd
Publication of EP0957769A1 publication Critical patent/EP0957769A1/en
Publication of EP0957769B1 publication Critical patent/EP0957769B1/en
Application granted granted Critical
Publication of EP0957769B9 publication Critical patent/EP0957769B9/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
    • G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
    • G01S15/8934—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a dynamic transducer configuration
    • G01S15/8938—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a dynamic transducer configuration using transducers mounted for mechanical movement in two dimensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0858—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving measuring tissue layers, e.g. skin, interfaces

Definitions

  • the present invention relates to an apparatus for an investigation of tissue based on the emission and reception of ultrasound.
  • an ultrasonic transducer is linked acoustically to the skin of a patient, optionally with the introduction of an appropriate coupling and lubricating medium.
  • Ultrasonic pulses transmitted into the patient are then reflected from reflecting surfaces at interfaces between the various layers of tissue within the patient.
  • the reflected pulses are received by the transducer and signals representative of the pulses are generated and combined by appropriate computing means to enable a visual representation of the zone of treatment of the patient to be recreated.
  • Human and other animal tissues are arranged in layers from superficial to deep usually comprising the outermost layer of epidermis, followed by papillary and reticular layers of dermis, beneath which lies a layer of fat. and then other tissues such as tendon, ligament. muscle and bone.
  • a proportion of the ultrasonic input will be reflected and can be received to generate a visually identifiable picture of the condition at any one particular interface. This enables and aids diagnosis of any disorder of the skin or underlying tissue.
  • an apparatus for ultrasonic tissue investigation comprising ultrasonic transducer means adapted to emit pulsed emissions into tissue, means so to move said transducer means as to scan an area of tissue to be investigated, means to receive signals reflected from interfaces between tissue layers, means to convert said received signals into a visual image of the tissue, and means to display said visual image, wherein said emissions of ultrasonic radiation are so pulsed that each pulse has a very rapid fall back period.
  • the received signals are split into positive and negative part signals, each of which is separately amplified by log compressor means, with the amplified signals being recombined to give an input to said means to convert said recombined signals into a visual image.
  • the means to move said ultrasonic transducer may be a stepper motor adapted to move said ultrasonic transducer within an area having a travel of up to approximately 15mm, using a transducer of diameter up to approximately 6mm.
  • Each scan of the area may involve a plurality of pulses, having a pulse repetition frequency in the region of 1ms, each pulse being of duration less than 50ns.
  • a method of tissue investigation comprising scanning an area of tissue using an apparatus as described above.
  • Fig. l is a cross sectional view ⁇ l ' a ⁇ be head 1 ' ⁇ use in the ⁇ ics ul invciition;
  • Fig.2 is a diagram of the circuit for the probe pulser and preamplifier of the present invention.
  • Fig.3 is a circuit diagram for the log amplifier system of the present invention.
  • Fig.4 shows the system in a schematic form
  • Fig.5 shows schematically the electronic systems of the probe
  • Fig.6 shows schematically the electronic systems of the main RF amplifier.
  • Fig. l shows an apparatus for application to an area of skin, of a patient or hide.
  • the apparatus comprises a transducer 1 , which may be moved by means of a stepper motor 2 to scan an area of tissue on or under that particular area of skin.
  • the motor 2 drives shaft 4, which is supported between an external shift bearing 5 and an internal shaft bearing 6, and the transducer 1 is movable between positions 1 and la as shown in Fig 1.
  • the transducer is driven along the shaft by means of flexible drive 7, although connection may also be made through link arm 8.
  • the transducer 1, housed within cone 9, has preferably a piezoelectric polymer element capable of emitting a single cycle pulse at a frequency of between 10 and 50MHz.
  • the preferred centre frequency is in the region of 20MHz and, as will be described below, the probe transducer is activated at a high voltage, and the system is adapted to cause an ultra fast rise and fall time pulse. The sharp signals given thereby enable a better reception of the reflected signals.
  • the control electronics of the system are housed in area 3 and are described in more detail below.
  • the probe electronics contain a pulse generator for energising the ultrasound transducer and a preamplifier for the returning signal.
  • the time gain compensator and motor control unit contains the main signal amplifier and the control and drive electronics for the probe motor. This may be connected to a compatible computer along with an analogue to digital converter board.
  • the probe electronics there are two pans. I ' irstly the ⁇ ulsci . which ⁇ .encraics an uln a last signal of rise and fall time ( > 30kV/ ⁇ s) very short duration ( ⁇ 20ns) high voltage pulse ( > 300V).
  • the pulse is produced from a single low voltage (4- 12 volt) supply to the board.
  • the pulse is created by the back emf of a small inductor acting as an impedance transformer with an avalanche transistor to limit the pulse duration and to produce an ultra fast fall time for the pulse.
  • Pulse triggering is generated by a 3 ⁇ s 5 volt positive supplied to pin 1 of JPI. This causes the inputs to U2 of the 74HCT14 hex inverting Schmitt triggered buffer to go high for 3 ⁇ s.
  • the turn on speed of Ql is limited by Rl and the gate capacitance of Ql. This prevents a significant pulse from the in-rush current into Tl, which saturates within 3 ⁇ s.
  • the outputs of U2 go high turning Q2 on quickly which turns off Ql in less than 10ns. This causes a back emf pulse of in excess of 600 volts to be generated across Tl.
  • a preamplifier with input protection which consists of a standard current mode opamp with the input protected by a diode bridge.
  • This amplifier has a voltage gain of 17 (12.3dB).
  • the received signal having been preamplified, is fed to a time gain compensation circuit to allow for attenuation through the various layers of tissue being investigated.
  • An amplifier consists of five stages.
  • the first stage is a variable gain amplifier with a -lOdB to +30dB control. This acts as overall gain control for the system.
  • the second stage is a variable gain amplifier and ramp generator with a 0 to + 30dB control range that is ramped at a controlled rate and acts as the time gain compensation.
  • the third stage is a precision rectifier that splits the signal into the positive and negative parts ⁇ l ' the signal, and lor the fourth stage, a log compressor consisting of two 50dB log amps. The output of these two log amps is recombined in the fifth stage and buffered to give a 50 ohm output for input to the analogue/digital converter.
  • a motor control comprises a bipolar stepper motor drive using MOSFET transistors with phase sequencing provided by a specially programmed PAL.
  • the step rate and step count is controlled by d e host computer through an industrial standard S254 counter/timer IC.
  • the signal has an improved range and discrimination when transferred to an analogue digital converter and thence to the computing means and visual display means.
  • Value can be added to the visual display by subjecting the returned signals either to a process of fractal analysis, wavelet analysis or a fast Fourier transform.
  • Fractal analysis comprises representing the region of interest of the skin and underlying tissue as a three dimensional landscape, with lateral and axial dimensions on a horizontal plane and the intensity of the image (0-256) on a vertical axis.
  • the area of landscape can then be mapped using flat disc shaped structuring elements with no height in a grey scale dimension and using techniques of mathematical morphology, the surface area of the image can be measured at different resolutions by removing features of less than a particular size. According to the method, this can be performed for resolutions between 1 pixel up to 20 pixels. At any given resolution, the rate of change of the surface area with respect to resolution is related to the estimated fractal dimension at that resolution.
  • the set of estimated fractal dimensions up to resolutions of 20 pixels defines the fractal signature.
  • Apparatus embodying the invention will find use in identifying and diagnosing tumours. injuries and any other abnormal condition up to depth of 3-5cm below the skin surface being investigated. Such noninvasive investigation is obviously a benefit to the patient and the apparatus provides a means of carrying out such investigation quickly, and with the advantage of giving clear images of any problem which may be encountered within the tissue surveyed.
  • One further use of the invention is in the testing of hides, sheepskins, and other materials used for commercial purposes such as clothing or footwear.
  • the value of the hide will depend upon its surface perfection. This is not easy to see until the hair (or wool or the like) has been removed.
  • the apparatus of the present invention can be used to scan a hide from an "inside” (deep) surface thereof and determine whether imperfections are likely to appear on the opposite "outside” surface once the hair has been removed.

Abstract

The apparatus for ultrasonic tissue investigation comprises an ultrasonic transducer (1) adapted to emit pulsed emissions into tissue and means (2) to move the transducer to scan an area of tissue to be investigated. Signals reflected from interfaces between acoustically different tissue components are received and converted into a representation of the tissue, which may be visually displayed. The emissions of ultrasonic radiation are so pulsed that each pulse has a very rapid fall back period, enabling better discrimination. Interpretation of the images may be facilitated by use of such techniques as fractal analysis.

Description

Apparatus for Ultrasonic Tissue Investigation
The present invention relates to an apparatus for an investigation of tissue based on the emission and reception of ultrasound.
It is known to use ultrasound to carry out investigations of the human body and other animal bodies. In these cases, an ultrasonic transducer is linked acoustically to the skin of a patient, optionally with the introduction of an appropriate coupling and lubricating medium. Ultrasonic pulses transmitted into the patient are then reflected from reflecting surfaces at interfaces between the various layers of tissue within the patient. The reflected pulses are received by the transducer and signals representative of the pulses are generated and combined by appropriate computing means to enable a visual representation of the zone of treatment of the patient to be recreated.
One example of the use of such techniques is ultrasonic scanning of a foetus in a pregnant mothers womb.
Human and other animal tissues are arranged in layers from superficial to deep usually comprising the outermost layer of epidermis, followed by papillary and reticular layers of dermis, beneath which lies a layer of fat. and then other tissues such as tendon, ligament. muscle and bone. At each of the interfaces between these various layers, a proportion of the ultrasonic input will be reflected and can be received to generate a visually identifiable picture of the condition at any one particular interface. This enables and aids diagnosis of any disorder of the skin or underlying tissue. However, presently available techniques cannot always ^ivr a clear enoug view of any li ely problem, and it is therefore an object of the present invention to provide an apparatus which will give an improved representation of the condition of a patient at a desired location within or beneath the skin.
According to a first aspect of the present invention there is provided an apparatus for ultrasonic tissue investigation comprising ultrasonic transducer means adapted to emit pulsed emissions into tissue, means so to move said transducer means as to scan an area of tissue to be investigated, means to receive signals reflected from interfaces between tissue layers, means to convert said received signals into a visual image of the tissue, and means to display said visual image, wherein said emissions of ultrasonic radiation are so pulsed that each pulse has a very rapid fall back period.
Preferably there are provided means to analyse the data from which these images are produced.
Preferably, the received signals are split into positive and negative part signals, each of which is separately amplified by log compressor means, with the amplified signals being recombined to give an input to said means to convert said recombined signals into a visual image.
The means to move said ultrasonic transducer may be a stepper motor adapted to move said ultrasonic transducer within an area having a travel of up to approximately 15mm, using a transducer of diameter up to approximately 6mm.
Each scan of the area may involve a plurality of pulses, having a pulse repetition frequency in the region of 1ms, each pulse being of duration less than 50ns.
According to a second aspect of the present invention there is provided a method of tissue investigation comprising scanning an area of tissue using an apparatus as described above.
An embodiment of the present invention will now be more particularly described by way of example, and with reference to the accompanying drawings, in which: Fig. l is a cross sectional view υl' a μϊυbe head 1'υι use in the μics ul invciition;
Fig.2 is a diagram of the circuit for the probe pulser and preamplifier of the present invention.
Fig.3 is a circuit diagram for the log amplifier system of the present invention;
Fig.4 shows the system in a schematic form;
Fig.5 shows schematically the electronic systems of the probe; and
Fig.6 shows schematically the electronic systems of the main RF amplifier.
Referring now to the drawings, Fig. l shows an apparatus for application to an area of skin, of a patient or hide. The apparatus comprises a transducer 1 , which may be moved by means of a stepper motor 2 to scan an area of tissue on or under that particular area of skin. The motor 2 drives shaft 4, which is supported between an external shift bearing 5 and an internal shaft bearing 6, and the transducer 1 is movable between positions 1 and la as shown in Fig 1.
The transducer is driven along the shaft by means of flexible drive 7, although connection may also be made through link arm 8.
The transducer 1, housed within cone 9, has preferably a piezoelectric polymer element capable of emitting a single cycle pulse at a frequency of between 10 and 50MHz. The preferred centre frequency is in the region of 20MHz and, as will be described below, the probe transducer is activated at a high voltage, and the system is adapted to cause an ultra fast rise and fall time pulse. The sharp signals given thereby enable a better reception of the reflected signals.
The control electronics of the system are housed in area 3 and are described in more detail below. Of these, the probe electronics contain a pulse generator for energising the ultrasound transducer and a preamplifier for the returning signal. The time gain compensator and motor control unit contains the main signal amplifier and the control and drive electronics for the probe motor. This may be connected to a compatible computer along with an analogue to digital converter board. In the probe electronics there are two pans. I 'irstly the μulsci . which ^.encraics an uln a last signal of rise and fall time ( > 30kV/μs) very short duration ( < 20ns) high voltage pulse ( > 300V). The pulse is produced from a single low voltage (4- 12 volt) supply to the board. The pulse is created by the back emf of a small inductor acting as an impedance transformer with an avalanche transistor to limit the pulse duration and to produce an ultra fast fall time for the pulse.
Power is supplied to the circuit through pins 2 and 3 of JPI. Pulse triggering is generated by a 3μs 5 volt positive supplied to pin 1 of JPI. This causes the inputs to U2 of the 74HCT14 hex inverting Schmitt triggered buffer to go high for 3μs. The turn on speed of Ql is limited by Rl and the gate capacitance of Ql. This prevents a significant pulse from the in-rush current into Tl, which saturates within 3μs. On the falling edge of the trigger pulse the outputs of U2 go high turning Q2 on quickly which turns off Ql in less than 10ns. This causes a back emf pulse of in excess of 600 volts to be generated across Tl. This is stepped down to a 300 volt pulse at the output of Tl . The diodes in DP3 conduct and the pulse is fed to the transducer connected to J l . When the output pulse voltage reaches greater than 300 volts Q3 breaks down in an avalanche shorting transformer and limits the pulse duration.
In this respect there is provided a preamplifier with input protection, which consists of a standard current mode opamp with the input protected by a diode bridge. This amplifier has a voltage gain of 17 (12.3dB).
The received signal, having been preamplified, is fed to a time gain compensation circuit to allow for attenuation through the various layers of tissue being investigated.
An amplifier consists of five stages. The first stage is a variable gain amplifier with a -lOdB to +30dB control. This acts as overall gain control for the system. The second stage is a variable gain amplifier and ramp generator with a 0 to + 30dB control range that is ramped at a controlled rate and acts as the time gain compensation. The third stage is a precision rectifier that splits the signal into the positive and negative parts υl' the signal, and lor the fourth stage, a log compressor consisting of two 50dB log amps. The output of these two log amps is recombined in the fifth stage and buffered to give a 50 ohm output for input to the analogue/digital converter.
Secondly, a motor control comprises a bipolar stepper motor drive using MOSFET transistors with phase sequencing provided by a specially programmed PAL. The step rate and step count is controlled by d e host computer through an industrial standard S254 counter/timer IC.
By keeping apart the positive and negative parts of the return signal, and then combining them after amplification it has been found that the signal has an improved range and discrimination when transferred to an analogue digital converter and thence to the computing means and visual display means.
Value can be added to the visual display by subjecting the returned signals either to a process of fractal analysis, wavelet analysis or a fast Fourier transform.
Fractal analysis comprises representing the region of interest of the skin and underlying tissue as a three dimensional landscape, with lateral and axial dimensions on a horizontal plane and the intensity of the image (0-256) on a vertical axis. The area of landscape can then be mapped using flat disc shaped structuring elements with no height in a grey scale dimension and using techniques of mathematical morphology, the surface area of the image can be measured at different resolutions by removing features of less than a particular size. According to the method, this can be performed for resolutions between 1 pixel up to 20 pixels. At any given resolution, the rate of change of the surface area with respect to resolution is related to the estimated fractal dimension at that resolution. The set of estimated fractal dimensions up to resolutions of 20 pixels defines the fractal signature.
Experiments show that, in using this system, various areas of tissue have a distinctive signature. For example, signatures from forehead tissue and regions of the hand lie particularly close together throughout pixel size, especially in the range of 2-5 pixels, peaking will. fractal dimensions between .5 and -1.0 al 5 pixels. Oilier parts of the body gave different signatures, for example a scan of heel tissue peaks at 9 pixels with a fractal dimension of 3.2.
Similar experiments using fast Fourier transforms (FFTs) have shown that the heel sample shows the lowest overall curve amplitude, whilst the samples from equivalent tissues of the hand show a remarkable similarity in curved shape and size, from whichever part of the hand the samples were taken. Samples taken from forehead tissue show the greatest amplitude at the first peak, with the second peak lower, showing the prevalence of narrow bands. Samples from hand and heel tissues show second peaks larger than the first ones, showing the prevalence of wide bands.
It is thought that fractal analysis will give different signatures for normal and damaged tissues, and the information can be stored for use as a comparison in all future studies. A databank built up in this way would be able to give more immediate attention to any abnormalities in the tissue being examined.
Apparatus embodying the invention will find use in identifying and diagnosing tumours. injuries and any other abnormal condition up to depth of 3-5cm below the skin surface being investigated. Such noninvasive investigation is obviously a benefit to the patient and the apparatus provides a means of carrying out such investigation quickly, and with the advantage of giving clear images of any problem which may be encountered within the tissue surveyed.
One further use of the invention is in the testing of hides, sheepskins, and other materials used for commercial purposes such as clothing or footwear. In this case, the value of the hide will depend upon its surface perfection. This is not easy to see until the hair (or wool or the like) has been removed. The apparatus of the present invention can be used to scan a hide from an "inside" (deep) surface thereof and determine whether imperfections are likely to appear on the opposite "outside" surface once the hair has been removed.

Claims

CLAIMS:
1. An apparatus for ultrasonic tissue investigation comprising ultrasonic transducer means adapted to emit pulsed emissions into tissue, means so to move said transducer means as to scan an area of tissue to be investigated, means to receive signals reflected from interfaces between tissue components means to convert said received signals into a visual image of the tissue, and means to display said visual image, wherein said emissions of ultrasonic radiation are so pulsed that each pulse has a very rapid fall back period.
2. An apparatus according to claim 1, wherein the received signals are split into positive and negative part signals, each of which is separately amplified, optionally by log compressor means, with the amplified signals being recombined to give an input to said means to convert said recombined signals into a visual image.
3. An apparatus as claimed in either claim I or claim 2. wherein said signal converting means comprises additionally means to analyse said signals.
4. An apparatus as claimed in claim 3, wherein said analysis means comprises means to perform fractal analysis, wavelet analysis or a fast Fourier transform.
5. An apparatus according to any one of the preceding claims, wherein the means to move said ultrasonic transducer is a stepper motor, preferably adapted to move said ultrasonic transducer within an area having a travel of up to 15mm.
6. An apparatus according to claim 5. wherein the transducer element has a diameter in the region of up to 6mm.
7. An apparatus according to claim 1 , wherein each scan of said area of tissue involves a plurality of pulses, having a pulse repetition frequency in the region of 1ms, each pulse being of duration less than 50ns.
8. Λ method of tissue investigation comprising scanning an area of tissue using an apparatus which comprises ultrasonic transducer means adapted to emit pulse emissions into tissue, means so to move said transducer means as to scan the area of tissue to be investigated, means to receive signals reflected from interfaces between tissue layers within said area, means to convert said received signals into a visual image of the tissue and means to display said visual image, wherein said emissions of ultrasonic radiation are so pulsed that each pulse has a very rapid fall back period.
9. A method of tissue investigation comprising scanning an area/volume of tissue to be investigated by a moving ultrasonic transducer means emitting pulsed emissions, each having a very rapid fall back period, into said tissue, receiving signals reflected from tissue component interfaces, converting said received signals into a visual image of the tissue, and displaying said visual image.
10. A method as claimed in either claim 8 or claim 9. further comprising the step of analysing said signals, optionally by fractal analysis, w avelet analysis or fast Fourier transform.
1 1. A method of tissue investigation, as claimed in any one of claims 8 to 10. wherein the tissue is a hide, sheepskin or other usable animal product.
12. A method as claimed in claim 1 1 , wherein the scanning means is applied to an interior (deep) side of the hide, sheepskin or other usably animal tissue to defect imperfections on a surface thereof which is obscured by hair, fur, wool or other keratinous material.
13. A method of tissue investigation, comprising the steps of carrying out the method of any one of claims 8 to 12, storing said received signals, carrying out the method on an area of tissue, and comparing the signals received with those stored for a comparative area of tissue.
EP96905953A 1995-03-09 1996-03-11 Apparatus for ultrasonic tissue investigation Expired - Lifetime EP0957769B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9504751 1995-03-09
GBGB9504751.0A GB9504751D0 (en) 1995-03-09 1995-03-09 Apparatus for ultrasonic tissue investigation
PCT/GB1996/000566 WO1996028096A1 (en) 1995-03-09 1996-03-11 Apparatus for ultrasonic tissue investigation

Publications (3)

Publication Number Publication Date
EP0957769A1 true EP0957769A1 (en) 1999-11-24
EP0957769B1 EP0957769B1 (en) 2006-03-29
EP0957769B9 EP0957769B9 (en) 2007-02-21

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US (1) US6073045A (en)
EP (1) EP0957769B9 (en)
JP (1) JPH11507846A (en)
AU (1) AU721503B2 (en)
DE (1) DE69635983T2 (en)
ES (1) ES2264137T3 (en)
GB (1) GB9504751D0 (en)
WO (1) WO1996028096A1 (en)
ZA (1) ZA961941B (en)

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US20060241495A1 (en) * 2005-03-23 2006-10-26 Eastman Kodak Company Wound healing monitoring and treatment
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US9184369B2 (en) 2008-09-18 2015-11-10 Fujifilm Sonosite, Inc. Methods for manufacturing ultrasound transducers and other components
EP3309823B1 (en) 2008-09-18 2020-02-12 FUJIFILM SonoSite, Inc. Ultrasound transducers
US9173047B2 (en) 2008-09-18 2015-10-27 Fujifilm Sonosite, Inc. Methods for manufacturing ultrasound transducers and other components
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Also Published As

Publication number Publication date
GB9504751D0 (en) 1995-04-26
WO1996028096A1 (en) 1996-09-19
AU721503B2 (en) 2000-07-06
EP0957769B1 (en) 2006-03-29
DE69635983D1 (en) 2006-05-18
US6073045A (en) 2000-06-06
ES2264137T3 (en) 2006-12-16
AU4950996A (en) 1996-10-02
EP0957769B9 (en) 2007-02-21
ZA961941B (en) 1996-09-20
DE69635983T2 (en) 2006-12-21
JPH11507846A (en) 1999-07-13

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