EP0957166A4 - IMMUNOGLOBULINE HUMANISEE REAGISSANT SPECIFIQUEMENT AVEC UN LIGAND Fas OU L'UN DE SES FRAGMENTS ACTIFS ET REGION D'INDUCTION D'APOPTOSE PRENANT NAISSANCE DANS UN LIGAND Fas - Google Patents

IMMUNOGLOBULINE HUMANISEE REAGISSANT SPECIFIQUEMENT AVEC UN LIGAND Fas OU L'UN DE SES FRAGMENTS ACTIFS ET REGION D'INDUCTION D'APOPTOSE PRENANT NAISSANCE DANS UN LIGAND Fas

Info

Publication number
EP0957166A4
EP0957166A4 EP97937807A EP97937807A EP0957166A4 EP 0957166 A4 EP0957166 A4 EP 0957166A4 EP 97937807 A EP97937807 A EP 97937807A EP 97937807 A EP97937807 A EP 97937807A EP 0957166 A4 EP0957166 A4 EP 0957166A4
Authority
EP
European Patent Office
Prior art keywords
fas ligand
originating
active fragments
inducing apoptosis
humanized immunoglobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97937807A
Other languages
German (de)
English (en)
Other versions
EP0957166A1 (fr
Inventor
Ko Okumura
Motomi Nakata
Hirofumi Higuchi
Yoshitaka Ushio
Hiroaki Maeda
Yasuyuki Eda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OKUMURA, KO
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP05023018A priority Critical patent/EP1642908A2/fr
Publication of EP0957166A1 publication Critical patent/EP0957166A1/fr
Publication of EP0957166A4 publication Critical patent/EP0957166A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
EP97937807A 1996-09-02 1997-08-27 IMMUNOGLOBULINE HUMANISEE REAGISSANT SPECIFIQUEMENT AVEC UN LIGAND Fas OU L'UN DE SES FRAGMENTS ACTIFS ET REGION D'INDUCTION D'APOPTOSE PRENANT NAISSANCE DANS UN LIGAND Fas Withdrawn EP0957166A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05023018A EP1642908A2 (fr) 1996-09-02 1997-08-27 Région d'induction d'apoptose prenant naissance dans un ligand fas

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP23174296 1996-09-02
JP23174296 1996-09-02
JP27154696 1996-09-20
JP27154696 1996-09-20
PCT/JP1997/002983 WO1998010070A1 (fr) 1996-09-02 1997-08-27 IMMUNOGLOBULINE HUMANISEE REAGISSANT SPECIFIQUEMENT AVEC UN LIGAND Fas OU L'UN DE SES FRAGMENTS ACTIFS ET REGION D'INDUCTION D'APOPTOSE PRENANT NAISSANCE DANS UN LIGAND Fas

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP05023018A Division EP1642908A2 (fr) 1996-09-02 1997-08-27 Région d'induction d'apoptose prenant naissance dans un ligand fas

Publications (2)

Publication Number Publication Date
EP0957166A1 EP0957166A1 (fr) 1999-11-17
EP0957166A4 true EP0957166A4 (fr) 2004-12-15

Family

ID=26530062

Family Applications (2)

Application Number Title Priority Date Filing Date
EP97937807A Withdrawn EP0957166A4 (fr) 1996-09-02 1997-08-27 IMMUNOGLOBULINE HUMANISEE REAGISSANT SPECIFIQUEMENT AVEC UN LIGAND Fas OU L'UN DE SES FRAGMENTS ACTIFS ET REGION D'INDUCTION D'APOPTOSE PRENANT NAISSANCE DANS UN LIGAND Fas
EP05023018A Withdrawn EP1642908A2 (fr) 1996-09-02 1997-08-27 Région d'induction d'apoptose prenant naissance dans un ligand fas

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP05023018A Withdrawn EP1642908A2 (fr) 1996-09-02 1997-08-27 Région d'induction d'apoptose prenant naissance dans un ligand fas

Country Status (5)

Country Link
US (1) US6777540B1 (fr)
EP (2) EP0957166A4 (fr)
AU (1) AU725329B2 (fr)
CA (1) CA2264968A1 (fr)
WO (1) WO1998010070A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US8030025B2 (en) 2008-02-20 2011-10-04 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1082967B1 (fr) * 1998-05-29 2006-07-19 Mochida Pharmaceutical Co., Ltd. Prévention et traitement de maladies autoimmunes démyélinisantes par des antagonistes du Fas
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
ES2346205T3 (es) 2002-12-17 2010-10-13 Merck Patent Gmbh Anticuerpo humanizado (h14.18) del anticurpo 14.18 de raton que se enlaza con gd2 y su fusion con la il-2.
EP1860120B1 (fr) 2005-02-08 2018-01-24 The Chemo-Sero-Therapeutic Research Institute Procédé permettant d'améliorer un anticorps
US8022188B2 (en) * 2006-04-24 2011-09-20 Abbott Laboratories Immunosuppressant binding antibodies and methods of obtaining and using same
DK2101877T3 (da) 2006-12-28 2013-09-23 Deutsches Krebsforsch Neutralisering af virkningen af CD95 til blokering af invasion af glioblastomceller in vivo
PL2231708T3 (pl) * 2007-12-12 2015-09-30 Pincell Srl Środki lecznicze na pęcherzycę zawierające przeciwciała anty ligand Fas
CN101357942B (zh) * 2008-05-30 2012-01-04 中国人民解放军第三军医大学 一种中和肠出血性大肠杆菌0157：H7志贺毒素Ⅱ的单克隆抗体、Fab抗体与应用
US8278065B2 (en) 2008-06-30 2012-10-02 Morphotek, Inc. Polynucleotides encoding anti-GD2 antibodies
WO2010019565A2 (fr) * 2008-08-12 2010-02-18 Medlmmune, Llc Anticorps anti-ephrine b2 et leur utilisation dans le traitement de maladies
JP5773882B2 (ja) 2008-12-12 2015-09-02 ピンチェル ソチエタ・レスポンサビリタ・リミタータＰｉｎＣｅｌｌ ｓｒｌ 抗ＦａｓＬリガンド抗体を含有する天疱瘡用治療薬
CA2775159A1 (fr) * 2009-09-25 2011-03-31 Shanghai National Engineering Research Center Of Antibody Medicine Co., Ltd. Procede d'acquisition de proteines presentant une forte affinite au moyen d'une technique de conception assistee par ordinateur
EP3076179A1 (fr) 2015-03-30 2016-10-05 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Diagnostic et traitement de gliomes mal différenciés
EP3353208B1 (fr) 2015-09-23 2024-08-07 Apogenix AG Anticorps anti-cd95l
GB202016058D0 (en) 2020-10-09 2020-11-25 Ucl Business Ltd Therapeautic treatment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007861A1 (fr) * 1988-12-28 1990-07-26 Protein Design Labs, Inc. IMMUNOGLOBULINES CHIMERIQUES SPECIFIQUES CONTRE LA PROTEINE TAC p55 DU RECEPTEUR D'IL-2
WO1995013293A1 (fr) * 1993-11-10 1995-05-18 Mochida Pharmaceutical Co., Ltd. Ligand fas, partie de ce dernier, et adn codant pour ce dernier
WO1996029350A1 (fr) * 1995-03-20 1996-09-26 Sumitomo Electric Industries, Ltd. ANTICORPS MONOCLONAL REAGISSANT SPECIFIQUEMENT AVEC UN LIGAND Fas ET SON PROCEDE DE PRODUCTION
EP0842948A1 (fr) * 1995-06-30 1998-05-20 Mochida Pharmaceutical Co., Ltd. ANTICORPS DE LIGAND ANTIFas ET PROCEDE D'EPREUVE LE FAISANT INTERVENIR

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1995018819A1 (fr) 1994-01-07 1995-07-13 Immunex Corporation Ligand fixant l'antigene fas
US6114507A (en) * 1995-06-30 2000-09-05 Mochida Pharmaceutical Co., Ltd. Anti-Fas ligand antibody and assay method using the anti-Fas ligand antibody

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007861A1 (fr) * 1988-12-28 1990-07-26 Protein Design Labs, Inc. IMMUNOGLOBULINES CHIMERIQUES SPECIFIQUES CONTRE LA PROTEINE TAC p55 DU RECEPTEUR D'IL-2
WO1995013293A1 (fr) * 1993-11-10 1995-05-18 Mochida Pharmaceutical Co., Ltd. Ligand fas, partie de ce dernier, et adn codant pour ce dernier
EP0675200A1 (fr) * 1993-11-10 1995-10-04 Mochida Pharmaceutical Co., Ltd. Un ligand de FAS, un fragment de celui-ci et ADN l'encodant
WO1996029350A1 (fr) * 1995-03-20 1996-09-26 Sumitomo Electric Industries, Ltd. ANTICORPS MONOCLONAL REAGISSANT SPECIFIQUEMENT AVEC UN LIGAND Fas ET SON PROCEDE DE PRODUCTION
EP0872488A1 (fr) * 1995-03-20 1998-10-21 Sumitomo Electric Industries, Ltd. ANTICORPS MONOCLONAL REAGISSANT SPECIFIQUEMENT AVEC UN LIGAND Fas ET SON PROCEDE DE PRODUCTION
EP0842948A1 (fr) * 1995-06-30 1998-05-20 Mochida Pharmaceutical Co., Ltd. ANTICORPS DE LIGAND ANTIFas ET PROCEDE D'EPREUVE LE FAISANT INTERVENIR

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAYAGAKI: "Metalloproteinase-mediated release of human fas ligand", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 182, 1 December 1995 (1995-12-01), pages 1777 - 1783, XP002096854, ISSN: 0022-1007 *
See also references of WO9810070A1 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US8030025B2 (en) 2008-02-20 2011-10-04 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
US8221749B2 (en) 2008-02-20 2012-07-17 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof

Also Published As

Publication number Publication date
EP1642908A2 (fr) 2006-04-05
US6777540B1 (en) 2004-08-17
AU4030797A (en) 1998-03-26
CA2264968A1 (fr) 1998-03-12
AU725329B2 (en) 2000-10-12
EP0957166A1 (fr) 1999-11-17
WO1998010070A1 (fr) 1998-03-12

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