EP0949926A4 - Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih - Google Patents

Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih

Info

Publication number
EP0949926A4
EP0949926A4 EP97911906A EP97911906A EP0949926A4 EP 0949926 A4 EP0949926 A4 EP 0949926A4 EP 97911906 A EP97911906 A EP 97911906A EP 97911906 A EP97911906 A EP 97911906A EP 0949926 A4 EP0949926 A4 EP 0949926A4
Authority
EP
European Patent Office
Prior art keywords
benzodiazepine
inhibitors
hiv integrase
hydrazide derivatives
hydrazide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97911906A
Other languages
German (de)
English (en)
Other versions
EP0949926A1 (fr
Inventor
Ian M Bell
James P Guare Jr
Daria Jean Hazuda
Peter M Munson
Wayne J Thompson
Joseph P Vacca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9624375.3A external-priority patent/GB9624375D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0949926A1 publication Critical patent/EP0949926A1/fr
Publication of EP0949926A4 publication Critical patent/EP0949926A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97911906A 1996-10-31 1997-10-27 Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih Withdrawn EP0949926A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2934896P 1996-10-31 1996-10-31
US29348P 1996-10-31
GBGB9624375.3A GB9624375D0 (en) 1996-11-22 1996-11-22 Benzodiazepine hydrazide derivatives as inhibitors of HIV integrase
GB9624375 1996-11-22
PCT/US1997/019230 WO1998018473A1 (fr) 1996-10-31 1997-10-27 Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih

Publications (2)

Publication Number Publication Date
EP0949926A1 EP0949926A1 (fr) 1999-10-20
EP0949926A4 true EP0949926A4 (fr) 2001-01-17

Family

ID=26310468

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97911906A Withdrawn EP0949926A4 (fr) 1996-10-31 1997-10-27 Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih

Country Status (4)

Country Link
EP (1) EP0949926A4 (fr)
AU (1) AU4917397A (fr)
CA (1) CA2269135A1 (fr)
WO (1) WO1998018473A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2329134A1 (fr) * 1998-06-03 1999-12-09 David L. Clark Inhibiteurs de vih integrase
WO2000059867A1 (fr) * 1999-03-30 2000-10-12 Pharmacor Inc. Derives d'hydroxyphenyle possedant des proprietes inhibitrices de l'integrase du vih
US6362165B1 (en) 1999-03-30 2002-03-26 Pharmacor Inc. Hydroxyphenyl derivatives with HIV integrase inhibitory properties
US6313177B1 (en) 1999-04-30 2001-11-06 Pharmacor Inc. D-mannitol derivatives as HIV aspartyl protease inhibitors
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
WO2000068235A1 (fr) * 1999-05-12 2000-11-16 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Inhibiteurs de l'integrase du vih-1 a base de thiazepine
JP4719466B2 (ja) 2002-09-20 2011-07-06 アロー セラピューティクス リミテッド ベンゾジアゼピン誘導体およびそれらを含有する医薬組成物
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
MXPA06012342A (es) 2004-04-26 2007-01-17 Pfizer Inhibidores de la enzima integrasa del virus de la inmunodeficiencia humana.
WO2005103003A2 (fr) 2004-04-26 2005-11-03 Pfizer Inc. Inhibiteurs de l'enzyme integrase du vih

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9818473A1 *

Also Published As

Publication number Publication date
AU4917397A (en) 1998-05-22
WO1998018473A1 (fr) 1998-05-07
EP0949926A1 (fr) 1999-10-20
CA2269135A1 (fr) 1998-05-07

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