EP0949915A4 - Traitement de la demence associee a l'infection par le virus du sida (vih-1) au moyen de pieges a radicaux libres a base de nitrone - Google Patents

Traitement de la demence associee a l'infection par le virus du sida (vih-1) au moyen de pieges a radicaux libres a base de nitrone

Info

Publication number
EP0949915A4
EP0949915A4 EP97920402A EP97920402A EP0949915A4 EP 0949915 A4 EP0949915 A4 EP 0949915A4 EP 97920402 A EP97920402 A EP 97920402A EP 97920402 A EP97920402 A EP 97920402A EP 0949915 A4 EP0949915 A4 EP 0949915A4
Authority
EP
European Patent Office
Prior art keywords
hiv
infection
free radical
dementia associated
aids virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97920402A
Other languages
German (de)
English (en)
Other versions
EP0949915A1 (fr
Inventor
Robert Floyd
William Garland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oklahoma Medical Research Foundation
Centaur Pharmaceuticals Inc
Original Assignee
Oklahoma Medical Research Foundation
Centaur Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Medical Research Foundation, Centaur Pharmaceuticals Inc filed Critical Oklahoma Medical Research Foundation
Publication of EP0949915A1 publication Critical patent/EP0949915A1/fr
Publication of EP0949915A4 publication Critical patent/EP0949915A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP97920402A 1996-04-17 1997-04-17 Traitement de la demence associee a l'infection par le virus du sida (vih-1) au moyen de pieges a radicaux libres a base de nitrone Withdrawn EP0949915A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1570996P 1996-04-17 1996-04-17
US15709P 1996-04-17
PCT/US1997/006253 WO1997038683A1 (fr) 1996-04-17 1997-04-17 Traitement de la demence associee a l'infection par le virus du sida (vih-1) au moyen de pieges a radicaux libres a base de nitrone

Publications (2)

Publication Number Publication Date
EP0949915A1 EP0949915A1 (fr) 1999-10-20
EP0949915A4 true EP0949915A4 (fr) 2001-07-04

Family

ID=21773092

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97920402A Withdrawn EP0949915A4 (fr) 1996-04-17 1997-04-17 Traitement de la demence associee a l'infection par le virus du sida (vih-1) au moyen de pieges a radicaux libres a base de nitrone

Country Status (5)

Country Link
EP (1) EP0949915A4 (fr)
AU (1) AU725432B2 (fr)
CA (1) CA2251800A1 (fr)
NZ (1) NZ332315A (fr)
WO (1) WO1997038683A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005552A1 (fr) * 1989-10-17 1991-05-02 Oklahoma Medical Research Foundation Procede et compositions inhibant les troubles associes aux lesions oxydatives des tissus
US5185324A (en) * 1988-12-14 1993-02-09 Hoechst Aktiengesellschaft Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof
US5314917A (en) * 1991-03-22 1994-05-24 E. B. Michaels Research Associates, Inc. Method for inactivating enveloped viruses and sperm

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185324A (en) * 1988-12-14 1993-02-09 Hoechst Aktiengesellschaft Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof
WO1991005552A1 (fr) * 1989-10-17 1991-05-02 Oklahoma Medical Research Foundation Procede et compositions inhibant les troubles associes aux lesions oxydatives des tissus
US5314917A (en) * 1991-03-22 1994-05-24 E. B. Michaels Research Associates, Inc. Method for inactivating enveloped viruses and sperm

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FLOYD R A ET AL: "The neurotoxic role of nitric oxide in AIDS dementia and stroke and the prevention of its formation by alpha-phenyl-tert-butylnitrone (PBN).", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 22, no. 1-3, 1996, 26th Annual Meeting of the Society for Neuroscience;Washington, D.C., USA; November 16-21, 1996, pages 2141, XP000998212, ISSN: 0190-5295 *
See also references of WO9738683A1 *
TABATABAIE TAHEREH ET AL: "In vivo trapping of nitric oxide in the brain of neonatal rats treated with the HIV-1 envelope protein gp 120: Protective effects of alpha-phenyl-tert-butylnitrone.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 221, no. 2, 1996, pages 386 - 390, XP000991161, ISSN: 0006-291X *
THOMAS, CRAIG E. ET AL: "In vitro and in vivo activity of a novel series of radical trapping agents in model systems of CNS oxidative damage", ANN. N. Y. ACAD. SCI. ( 1994 ), 738(NEUROBIOLOGY OF NO.BUL. AND.BUL.OH), 243-249, 1994, XP000992143 *
YUE, TIAN LI ET AL: "Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons", BRAIN RES. ( 1992 ), 574(1-2), 193-7, 1992, XP000992139 *

Also Published As

Publication number Publication date
NZ332315A (en) 2000-03-27
AU725432B2 (en) 2000-10-12
CA2251800A1 (fr) 1997-10-23
AU2460697A (en) 1997-11-07
WO1997038683A1 (fr) 1997-10-23
EP0949915A1 (fr) 1999-10-20

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