EP0934098B1 - User activated iontophoretic device and method for activating same - Google Patents
User activated iontophoretic device and method for activating same Download PDFInfo
- Publication number
- EP0934098B1 EP0934098B1 EP97943526A EP97943526A EP0934098B1 EP 0934098 B1 EP0934098 B1 EP 0934098B1 EP 97943526 A EP97943526 A EP 97943526A EP 97943526 A EP97943526 A EP 97943526A EP 0934098 B1 EP0934098 B1 EP 0934098B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- reservoir
- drug
- electrode
- patch
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Description
Claims (14)
- A user-activated iontophoretic device (10) for use in delivering at least one drug (30) through an applied area of a patient, such as the skin, mucus membrane and the like, comprising barrier means (32) for sealingly separating an electrode reservoir (18) from a drug reservoir (20) which contains a drug (30) to be delivered to the applied area of the patient, wherein said device (10) is characterised bya first portion (24) and a second portion (26), said first portion (24) including an electrode assembly (16) and said electrode reservoir (18) and said second portion (26) including said drug reservoir (20),said electrode assembly (16) including electrode means which are for driving the drug (30) into the patient to be absorbed by the body of the patient and which are maintained in electrically communicating relation with the electrode reservoir (18),and wherein the drug (30) contained in the drug reservoir (20) is maintained separate in relation to the first portion (24) prior to activation by removal of the barrier means (32) so that, upon removal of said barrier means (32), the electrode reservoir (18) and the drug reservoir (20) are brought into fluid conducting contact with one another so that said drug (30) is hydrated or dissolved in an aqueous solution contained in said electrode reservoir (18).
- A device according to claim 1 which is separable to allow separation from the device, after said removal of the barrier means (32) from the device and said dissolution or hydration of the drug (30) in the aqueous medium, of a patch comprising the electrode assembly (16) and a combined reservoir comprising the electrode reservoir (18) and the hydrated or dissolved drug (30) and wherein the combined reservoir of the patch can be positioned in electrically conducting contact with the skin or mucous membrane of the patient.
- A device according to claim 2 in which said patch comprising the electrode assembly and the combined reservoir is separable from the device as a result of being peelable from the surface of the first portion (24) which is distant from the second portion (26).
- A device according to any preceding claim in which the drug is initially in a dry form separated from the electrode reservoir (18) and the barrier means (32) seal said electrode reservoir (18) in said first portion (24) and seal said drug reservoir (20) contained in said second portion (26).
- A device according to any preceding claim in which the drug is in a dry form and is homogeneously distributed in a carrier material so that the active compound may be kept in a dry form separated from the electrode reservoir (18), and the barrier means (32) maintain an aqueous solution in the electrode reservoir (18) intact during storage.
- A device according to any preceding claim in which the electrode reservoir includes an electrolyte.
- A device according to any preceding claim in which the electrode reservoir includes an electrically conductive gel.
- A device according to any preceding claim in which the drug is selected from the group including cell adhesion molecules, and GPIIb/IIIa receptor antagonists for the treatment of thromboembolic disorders.
- A device according to any preceding claim in which said barrier means (32) includes an upper release member (34) and a lower release member (36) and is constructed so that partial or complete removal of the upper and lower release members (34, 36) brings the electrode reservoir (18) and the drug reservoir (20) into fluid conducting contact with one another.
- A device according to claim 9 in which the upper release member (34) and lower release member (36) are interconnected by a pull tab member (38) extending from the first portion (24) and the second portion (26) so that upon pulling the tab member (38) to at least partially remove the barrier (32) from therebetween, the electrode reservoir (18) and the drug reservoir (20) are brought into contact with one another.
- A method of preparing an iontophoretic patch which comprises an electrode assembly (16) and a combined electrode and drug reservoir and which is suitable for subsequent use for iontophoretic delivery of a drug (30) to an applied area of skin or mucous membrane of a patient, wherein the method of preparing the patch comprisesproviding a device (10) comprisinga first portion (24) including the electrode assembly (16) and an electrode reservoir (18) which contains an aqueous solution and is covered by a first release member (34) anda second portion (26) including a drug reservoir (20) containing the drug (30) and covered by a second release member (36), andexposing the electrode reservoir (18) by at least partially removing the release member (34),exposing the drug reservoir (20) by at least partialy removing the second release member (36), andbringing the electrode reservoir (18) of the first portion (24) which includes the electrode assembly (16) into fluid-conducting contact with the drug reservoir (20) of the second portion (26) and thereby at least partially hydrating the drug (30) in the drug reservoir (20) by the aqueous solution in the electrode reservoir (18) to form the patch comprising the electrode assembly and the combined electrode and drug reservoir.
- A method according to claim 11 in which the electrode reservoir (18) and the drug reservoir (20) are brought into fluid-conducting contact by the at least partial removal of the release members (34, 36).
- A method according to claim 11 or claim 12 in which the at least partial removal of the release members (34, 36) comprises pulling a tab member (38) to simultaneously remove the release members (34, 36).
- A method according to any of claims 11 to 13 comprising, after forming the combined reservoir, removing the patch comprising the electrode assembly (16) and the combined reservoir from the first portion (24).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/722,813 US5738647A (en) | 1996-09-27 | 1996-09-27 | User activated iontophoretic device and method for activating same |
US722813 | 1996-09-27 | ||
PCT/US1997/017075 WO1998013099A1 (en) | 1996-09-27 | 1997-09-22 | User activated iontophoretic device and method for activating same |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0934098A1 EP0934098A1 (en) | 1999-08-11 |
EP0934098B1 true EP0934098B1 (en) | 2003-07-09 |
Family
ID=24903496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97943526A Expired - Lifetime EP0934098B1 (en) | 1996-09-27 | 1997-09-22 | User activated iontophoretic device and method for activating same |
Country Status (6)
Country | Link |
---|---|
US (1) | US5738647A (en) |
EP (1) | EP0934098B1 (en) |
JP (1) | JP4484250B2 (en) |
AU (1) | AU4497797A (en) |
DE (1) | DE69723453T2 (en) |
WO (1) | WO1998013099A1 (en) |
Families Citing this family (82)
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WO1997048395A1 (en) * | 1996-06-19 | 1997-12-24 | Du Pont Pharmaceuticals Company | Iontophoretic delivery of integrin inhibitors |
US20060002959A1 (en) * | 1996-11-14 | 2006-01-05 | Government Of The United States | Skin-sctive adjuvants for transcutaneous immuization |
US5980898A (en) * | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US20060002949A1 (en) * | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
US5848966A (en) * | 1997-03-04 | 1998-12-15 | Graphic Controls Corporation | Medical device easily removed from skin and a method of removal therefrom |
US20040258703A1 (en) * | 1997-11-14 | 2004-12-23 | The Government Of The Us, As Represented By The Secretary Of The Army | Skin-active adjuvants for transcutaneous immunization |
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WO2002064162A2 (en) * | 2001-02-13 | 2002-08-22 | Government Of The United States, As Represented By The Secretary Of The Army | Vaccine for transcutaneous immunization |
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-
1996
- 1996-09-27 US US08/722,813 patent/US5738647A/en not_active Expired - Lifetime
-
1997
- 1997-09-22 DE DE69723453T patent/DE69723453T2/en not_active Expired - Lifetime
- 1997-09-22 AU AU44977/97A patent/AU4497797A/en not_active Abandoned
- 1997-09-22 JP JP51585898A patent/JP4484250B2/en not_active Expired - Fee Related
- 1997-09-22 WO PCT/US1997/017075 patent/WO1998013099A1/en active IP Right Grant
- 1997-09-22 EP EP97943526A patent/EP0934098B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0934098A1 (en) | 1999-08-11 |
US5738647A (en) | 1998-04-14 |
JP4484250B2 (en) | 2010-06-16 |
WO1998013099A1 (en) | 1998-04-02 |
JP2001501508A (en) | 2001-02-06 |
DE69723453D1 (en) | 2003-08-14 |
DE69723453T2 (en) | 2004-04-15 |
AU4497797A (en) | 1998-04-17 |
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