EP0926495A1 - Procédé pour la détection de molécules sous utilisation d'une technologie numérique de micromiroir - Google Patents

Procédé pour la détection de molécules sous utilisation d'une technologie numérique de micromiroir Download PDF

Info

Publication number
EP0926495A1
EP0926495A1 EP98124574A EP98124574A EP0926495A1 EP 0926495 A1 EP0926495 A1 EP 0926495A1 EP 98124574 A EP98124574 A EP 98124574A EP 98124574 A EP98124574 A EP 98124574A EP 0926495 A1 EP0926495 A1 EP 0926495A1
Authority
EP
European Patent Office
Prior art keywords
mirrors
array
probes
mirror
steps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98124574A
Other languages
German (de)
English (en)
Other versions
EP0926495B1 (fr
Inventor
Robert J. Petcavich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Petcavich Robert J
Original Assignee
Petcavich Robert J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Petcavich Robert J filed Critical Petcavich Robert J
Publication of EP0926495A1 publication Critical patent/EP0926495A1/fr
Application granted granted Critical
Publication of EP0926495B1 publication Critical patent/EP0926495B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00439—Maskless processes using micromirror arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP98124574A 1997-12-23 1998-12-23 Procédé pour la détection de molécules sous utilisation d'une technologie numérique de micromiroir Expired - Lifetime EP0926495B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US996845 1997-12-23
US08/996,845 US5912181A (en) 1997-12-23 1997-12-23 Method for molecule detection utilizing digital micromirror technology

Publications (2)

Publication Number Publication Date
EP0926495A1 true EP0926495A1 (fr) 1999-06-30
EP0926495B1 EP0926495B1 (fr) 2003-10-15

Family

ID=25543369

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98124574A Expired - Lifetime EP0926495B1 (fr) 1997-12-23 1998-12-23 Procédé pour la détection de molécules sous utilisation d'une technologie numérique de micromiroir

Country Status (3)

Country Link
US (1) US5912181A (fr)
EP (1) EP0926495B1 (fr)
DE (1) DE69818957T2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271957B1 (en) * 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
US6657758B1 (en) 1998-06-04 2003-12-02 Board Of Regents, The University Of Texas System Variable spectrum generator system
WO2002005059A2 (fr) 2000-07-07 2002-01-17 Baxter International Inc. Systeme, procede et appareil medicaux utilisant des dispositifs mem
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US6567163B1 (en) 2000-08-17 2003-05-20 Able Signal Company Llc Microarray detector and synthesizer
SE0100889D0 (sv) 2001-03-14 2001-03-14 Biacore Ab Method and apparatus for attenuated total reflection spectrosopy
AU2002250325A1 (en) * 2001-03-15 2002-10-03 Molecular Reflection Method for monitoring the oscillatory characteristics of a microfabricated resonant mass sensor
WO2003008943A1 (fr) * 2001-07-19 2003-01-30 Tufts University Dispositif de reseau optique et procedes d'utilisation de ce dispositif pour le criblage, l'analyse et la manipulation de particules
AU2002351164A1 (en) * 2001-11-26 2003-06-10 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
AU2003276870A1 (en) * 2002-09-07 2004-03-29 Lightwave Bioapplications Bioanalysis systems including optical integrated circuit
US8524488B2 (en) * 2002-09-10 2013-09-03 The Regents Of The University Of California Methods and devices for determining a cell characteristic, and applications employing the same
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
WO2009033056A1 (fr) * 2007-09-06 2009-03-12 Bioscale, Inc. Surfaces de détection réutilisables et procédés pour leur utilisation
US20090112482A1 (en) * 2007-10-26 2009-04-30 Sandstrom Perry L Microarray detector and synthesizer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0664470A2 (fr) * 1993-12-21 1995-07-26 Texas Instruments Incorporated Dispositif de micro-miroir digitale à plusieurs niveaux
US5653939A (en) * 1991-11-19 1997-08-05 Massachusetts Institute Of Technology Optical and electrical methods and apparatus for molecule detection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0562424B1 (fr) * 1992-03-25 1997-05-28 Texas Instruments Incorporated Systéme integré d'étalonnage optique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5653939A (en) * 1991-11-19 1997-08-05 Massachusetts Institute Of Technology Optical and electrical methods and apparatus for molecule detection
EP0664470A2 (fr) * 1993-12-21 1995-07-26 Texas Instruments Incorporated Dispositif de micro-miroir digitale à plusieurs niveaux

Also Published As

Publication number Publication date
US5912181A (en) 1999-06-15
EP0926495B1 (fr) 2003-10-15
DE69818957D1 (de) 2003-11-20
DE69818957T2 (de) 2004-09-09

Similar Documents

Publication Publication Date Title
US5912181A (en) Method for molecule detection utilizing digital micromirror technology
US6737238B2 (en) Substrate measuring method and device
ES2668960T3 (es) Sensor de autocodificación con microesferas
CA2305545C (fr) Capteur optique autocodant a fibres
RU2242746C2 (ru) Кодированный микроноситель и способ кодирования микроносителей
CN101389961B (zh) 免疫分析微芯片、免疫分析用试剂盒及免疫分析方法
US20070040095A1 (en) Method and system of array imaging
US5936730A (en) Bio-molecule analyzer with detector array and filter device
US20030198573A1 (en) Sensor arrays for detecting analytes in fluids
CA2223927A1 (fr) Detection par procedes optiques des potentiels transmembranaires
WO2001034846A2 (fr) Correspondance directe de puces a adn avec des reseaux de detection
WO2000013004A2 (fr) Synthese de capteurs par combinaison de polymeres pour groupements de capteurs polymeres
JP2002525579A (ja) 微小球を利用する標的分析物センサー
JP2020079793A (ja) 生物学的実体におけるコンホメーションのハイスループット分析のためのシステムおよび方法
WO2002093144A1 (fr) Imagerie d'echantillons biologiques au moyen d'un photodetecteur electronique
CN1879020B (zh) 使用组合的人工受体的传感器
WO2003067936A1 (fr) Methode d'essai
US20030232384A1 (en) Microarray system utilizing microtiter plates
US20060229819A1 (en) Method for imaging an array of microspheres
Michael et al. Making sensors out of disarray: optical sensor microarrays
JP2002501489A (ja) コード付きケミカルライブラリーの調製方法
WO2001057501A1 (fr) Lecteur de jeux ordonnes de microechantillons ameliore
KR100953558B1 (ko) 표면 플라즈몬 공명을 이용한 ｐｓ-ｓｐｃｌ 탐색 장치 및방법
JP2002286717A (ja) 無蛍光担体およびこれを固相に用いた測定用セル、ならびに無蛍光担体を利用する濃度測定方法
AU2003200922B2 (en) Self-encoding fiber optic sensor

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): CH DE GB LI

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

17P Request for examination filed

Effective date: 19991223

AKX Designation fees paid

Free format text: CH DE GB LI

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PETCAVICH, ROBERT J.

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PETCAVICH, ROBERT J.

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): CH DE GB LI

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20031015

Ref country code: CH

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20031015

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 69818957

Country of ref document: DE

Date of ref document: 20031120

Kind code of ref document: P

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20031217

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20040202

Year of fee payment: 6

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20040716

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20041223

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050701

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20041223