EP0919215B1 - Glass ampule for holding a liquid - Google Patents
Glass ampule for holding a liquid Download PDFInfo
- Publication number
- EP0919215B1 EP0919215B1 EP97890231A EP97890231A EP0919215B1 EP 0919215 B1 EP0919215 B1 EP 0919215B1 EP 97890231 A EP97890231 A EP 97890231A EP 97890231 A EP97890231 A EP 97890231A EP 0919215 B1 EP0919215 B1 EP 0919215B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- ampoule
- area
- glass ampoule
- coating
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/065—Rigid ampoules, e.g. glass ampoules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Definitions
- the invention relates to a glass ampoule for holding a liquid, for example a drug, a calibration or quality control fluid, with a substantially flat floor or with an inside of the Ampoule retracted bottom area, the bottom area due to its shape has a defined predetermined breaking area, which requires little effort is mechanically destructible.
- a liquid for example a drug, a calibration or quality control fluid
- Such ampoules are used in large numbers, especially in medical laboratories as well as used in medical practices and clinics, with the glass ampoules for removal their contents are usually broken open by hand and used for their purpose Need to become.
- EP 0 694 498 B1 describes a device for automatic removal of a liquid from a sealed glass ampoule became known, in which the glass ampoule in an upright, the bottom the ampoule is held upward in a holder. The The bottom of the glass ampoule becomes mechanical through a rigid-walled, single-lumen cannula destroyed, this cannula at the same time to aspirate the liquid serves a splinter-free area of the glass ampoule.
- FR 1 241 230 A is a glass ampoule with one on the inside the ampoule retracted bottom area, which due to its Forming has a defined predetermined breaking area.
- the object of the invention is to provide known glass ampoules for holding liquids to further develop such that problem-free opening through the floor area is guaranteed by automatically operating removal devices.
- the floor area preferably a coating of the center of the drawn-in area a material, for example ceramic, which has tension forces between the coated floor area and the coating.
- a coating of a material which has tensile forces between the coated floor area and the coating.
- This ceramic coating for example, can also be in a punctiform formation on the center of the drawn-in area or limit the point of attack of a removal element.
- the floor area is asymmetrical, conical Has depression, the lowest point is arranged off-center.
- Such asymmetrical, conical depressions can, for example, with a blower is manufactured during the manufacturing process, wherein Wall parts of the ampoule bottom in a reproducible form and depth inside of the ampoule. Arches of approximately half the diameter the ampoule has proven to be advantageous. To strengthen the Wall area can be specifically cooled during the blowing and the optimal arching can be subjected to an automatic optical control. The reduced rigidity of the floor area due to the asymmetry allows es, a withdrawal cannula with much less effort in the glass ampoule introduce, the splintering essentially on the asymmetrical shaped area remains limited.
- Targeted asymmetries naturally have advantages over manufacturing-related asymmetries, such as e.g. known from GB 198,993 A, on.
- the indented floor area is a comparison reduced to the wall thickness of the glass ampoule, preferably reduced by 30 to 60% Has wall thickness.
- the wall thickness of the glass ampoule preferably reduced by 30 to 60% Has wall thickness.
- glass ampoules with an to provide essential flat ground, again for local weakening the surface tension of the soil preferably in its central Area has a ceramic coating, and possibly also the Bottom of the glass ampoule, especially in its central area, one in comparison reduced to the wall thickness of the glass ampoule, preferably by 30 to 60% reduced wall thickness.
- the glass ampoule 1 shown in Fig. 1a for receiving a liquid has a bottom region 2 drawn in to the inside of the ampoule.
- the cylindrical Shank area 3 of the ampoule 1 goes into a neck area 4 and this into a head area 5 over.
- the areas 3 to 4 can essentially be any be carried out, it only has to be guaranteed that the ampoule in one Device for automatic withdrawal of ampoule liquid - such as this is known from EP 0 694 498 B1 - can be used.
- the bottom region 2 of the ampoule according to FIG. 1a has a conical depression on, which in the center of the retracted area 2 a punctiform ceramic Has coating 7 (see also Fig. 1b).
- the embodiment according to FIGS. 2a and 2b has an asymmetrical, conical recess 6 'with reduced wall thickness, which means a central in the direction of the axis 1 'of the ampoule removal element 12 a reduced mechanical resistance when opening the floor.
- the ceramic coating 7 is also asymmetrical here, namely arranged at the deepest point of the conical recess 6 '.
- the base region 2 of the ampoule 1 executed with a substantially cylindrical recess 8, which a has flat or slightly curved floor 9.
- the wall thickness of the fed Floor area 2 can be entirely or only in a central area a reduced wall thickness compared to the wall thickness of the glass ampoule 1 exhibit.
- a glass ampoule 1 which has a substantially flat bottom 10, this for Whole or in its central area for easier penetration of the removal element has a reduced wall thickness (30 - 60%).
- Such floors can, for example, be welded or melted onto the shaft of the ampoule become.
- a ceramic one can also be found in the central area Coating 7 can be applied in the form of a ceramic point. It is also possible that the bottom area or the bottom 10 of the glass ampoule 1 is scored, preferably has a circular scoring 12.
- an elastomer coating indicated in FIG. 4a can be used in all design variants 11 can be provided, which on a to the floor 10 (or Bottom region 2) of the cylindrical shaft region 3 adjoining the glass ampoule 1 is applied. This elastomer coating serves to prevent any splinters in the to hold the lower shaft area.
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
Description
Die Erfindung betrifft eine Glasampulle zur Aufnahme einer Flüssigkeit, beispielsweise eines Arzneimittels, einer Kalibrier- oder einer Qualitätskontrollflüssigkeit, mit einem im wesentlichen ebenen Boden bzw. mit einem zur Innenseite der Ampulle eingezogenen Bodenbereich, wobei der Bodenbereich durch seine Formgebung einen definierten Sollbruchbereich aufweist, welcher mit geringem Kraftaufwand mechanisch zerstörbar ist.The invention relates to a glass ampoule for holding a liquid, for example a drug, a calibration or quality control fluid, with a substantially flat floor or with an inside of the Ampoule retracted bottom area, the bottom area due to its shape has a defined predetermined breaking area, which requires little effort is mechanically destructible.
Derartige Ampullen werden in großer Zahl vor allem in medizinischen Labors sowie in Arztpraxen und Kliniken verwendet, wobei die Glasampullen zur Entnahme ihres Inhaltes meist händisch aufgebrochen und ihrer Bestimmung zugeführt werden müssen.Such ampoules are used in large numbers, especially in medical laboratories as well as used in medical practices and clinics, with the glass ampoules for removal their contents are usually broken open by hand and used for their purpose Need to become.
Für viele Anwendungen, insbesondere bei der Kalibrierung und/oder Qualitätskontrolle von Laborgeräten ist allerdings der manuelle Aufwand bei der Zuführung der benötigten Flüssigkeiten aus Glasampullen von Nachteil.For many applications, especially calibration and / or quality control of laboratory devices, however, is the manual effort involved in feeding the required liquids from glass ampoules a disadvantage.
In diesem Zusammenhang ist aus der EP 0 694 498 B1 eine Vorrichtung zur automatischen Entnahme einer Flüssigkeit aus einer verschlossenen Glasampulle bekannt geworden, bei welcher die Glasampulle in einer aufrechten, den Boden der Ampulle nach oben weisenden Stellung in einer Halterung gehalten wird. Der Boden der Glasampulle wird durch eine starrwandige, einlumige Kanüle mechanisch zerstört, wobei diese Kanüle gleichzeitig zum Absaugen der Flüssigkeit aus einem splitterfreien Bereich der Glasampulle dient.In this context, EP 0 694 498 B1 describes a device for automatic removal of a liquid from a sealed glass ampoule became known, in which the glass ampoule in an upright, the bottom the ampoule is held upward in a holder. The The bottom of the glass ampoule becomes mechanical through a rigid-walled, single-lumen cannula destroyed, this cannula at the same time to aspirate the liquid serves a splinter-free area of the glass ampoule.
Probleme können vor allem dann entstehen, wenn durch die Zerstörung des Ampullenbodens auch Wandbereiche der Ampulle mitzerstört werden, bzw. relativ große Kräfte aufgewendet werden müssen, um das Entnahmeelement durch den Boden in die Ampulle einzuführen. Diese Probleme können auch dann nicht immer zufriedenstellend behoben werden, wenn der Ampullenboden gemäß FR 721 646 A in seinem Zentrum eine konische Depression aufweist.Problems can arise especially if the destruction of the Ampoule bottom also destroyed wall areas of the ampoule, or relatively large forces must be applied to the removal element insert the bottom into the ampoule. Even then, these problems cannot always be satisfactorily rectified if the ampoule base is in accordance with FR 721 646 A has a conical depression at its center.
Weiters ist aus der FR 1 241 230 A eine Glasampulle mit einem zur Innenseite
der Ampulle eingezogenen Bodenbereich bekannt geworden, welcher durch seine
Formgebung einen definierten Sollbruchbereich aufweist. Zum Öffnen wird die
Glasampulle mit dem Kopfbereich in den Hals eines Behälters eingeführt und
anschließend der Boden der Glasampulle durch ein stabförmiges Element mechanisch
zerstört. Mit dem stabförmigen Element wird weiters auch der Kopfbereich
der Glasampulle durchstoßen, wonach der Ampulleninhalt in den Behälter abfließen
kann.Furthermore,
Aufgabe der Erfindung ist es, bekannte Glasampullen zur Aufnahme von Flüssigkeiten derart weiterzubilden, dass ein problemloses Öffnen durch den Bodenbereich durch automatisch arbeitende Entnahmevorrichtungen gewährleistet ist.The object of the invention is to provide known glass ampoules for holding liquids to further develop such that problem-free opening through the floor area is guaranteed by automatically operating removal devices.
Diese Aufgabe wird erfindungsgemäß dadurch gelöst, dass der Bodenbereich, vorzugsweise das Zentrum des eingezogenen Bereiches eine Beschichtung aus einem Material, beispielsweise Keramik, aufweist, welches Spannungskräfte zwischen dem beschichteten Bodenbereich und der Beschichtung hervorruft.This object is achieved in that the floor area, preferably a coating of the center of the drawn-in area a material, for example ceramic, which has tension forces between the coated floor area and the coating.
Zur Reduzierung der örtlichen Oberflächenspannung des Bodenbereiches ist somit eine Beschichtung aus einem Material vorgesehen, welches Spannungskräfte zwischen dem beschichteten Bodenbereich und der Beschichtung hervorruft. Diese beispielsweise keramische Beschichtung kann sich auch in einer punktförmigen Ausbildung auf das Zentrum des eingezogenen Bereiches bzw. den Angriffspunkt eines Entnahmeelementes beschränken.To reduce the local surface tension of the floor area thus a coating of a material is provided which has tensile forces between the coated floor area and the coating. This ceramic coating, for example, can also be in a punctiform formation on the center of the drawn-in area or limit the point of attack of a removal element.
Weiter ist es von Vorteil, wenn der Bodenbereich eine asymmetrische, konische Vertiefung aufweist, deren tiefste Stelle außermittig angeordnet ist.It is also advantageous if the floor area is asymmetrical, conical Has depression, the lowest point is arranged off-center.
Derartige asymmetrische, konische Vertiefungen können beispielsweise mit einem Gebläse während des Herstellungsprozesses hergestellt werden, wobei Wandteile des Ampullenbodens in reproduzierbarer Form und Tiefe in das Innere der Ampulle eingeblasen werden. Einwölbungen von in etwa dem halben Durchmesser der Ampulle haben sich dabei als vorteilhaft erwiesen. Zur Stärkung des Wandbereiches kann dieser während des Einblasens gezielt abgekühlt und die optimale Einwölbung einer automatischen optischen Kontrolle unterworfen werden. Die durch die Asymmetrie verringerte Steifigkeit des Bodenbereiches erlaubt es, eine Entnahmekanüle mit wesentlich geringerem Kraftaufwand in die Glasampulle einzuführen, wobei die Splitterbildung im wesentlichen auf den asymmetrisch geformten Bereich beschränkt bleibt. Gezielt hergestellte Asymmetrien weisen naturgemäß Vorteile gegenüber herstellungsbedingten Asymmetrien, wie z.B. aus der GB 198,993 A bekannt, auf.Such asymmetrical, conical depressions can, for example, with a blower is manufactured during the manufacturing process, wherein Wall parts of the ampoule bottom in a reproducible form and depth inside of the ampoule. Arches of approximately half the diameter the ampoule has proven to be advantageous. To strengthen the Wall area can be specifically cooled during the blowing and the optimal arching can be subjected to an automatic optical control. The reduced rigidity of the floor area due to the asymmetry allows es, a withdrawal cannula with much less effort in the glass ampoule introduce, the splintering essentially on the asymmetrical shaped area remains limited. Targeted asymmetries naturally have advantages over manufacturing-related asymmetries, such as e.g. known from GB 198,993 A, on.
Zu einer weiteren Verringerung des Kraftaufwandes bei der Zerstörung des Bodens kommt es dadurch, dass der eingezogene Bodenbereich eine im Vergleich zur Wandstärke der Glasampulle verminderte, vorzugsweise um 30 bis 60% verringerte Wandstärke aufweist. Im Falle einer asymmetrischen Vertiefung können jene Wandbereiche der Vertiefung am dünnsten ausgeführt werden, wo das Entnahmeelement durchtritt. Weiters kommt es zu einem günstigen Angriffswinkel des Entnahmeelementes an dieser Stelle, wodurch weniger Kräfte auf den Randbereich der Ampulle übertragen werden.To further reduce the effort required to destroy the Soil comes from the fact that the indented floor area is a comparison reduced to the wall thickness of the glass ampoule, preferably reduced by 30 to 60% Has wall thickness. In the case of an asymmetrical depression you can those wall areas of the recess are made thinnest where the removal element passes. There is also a favorable angle of attack of the removal element at this point, which means less forces on the edge area the ampoule are transferred.
Ähnliche Effekte lassen sich auch dann erzielen, wenn der Bodenbereich eine im wesentlichen zylindrische Vertiefung mit einem ebenen oder leicht gewölbten Boden aufweist.Similar effects can also be achieved if the floor area has a essentially cylindrical recess with a flat or slightly curved Floor.
Im Rahmen der Erfindung ist es auch möglich, Glasampullen mit einem im wesentlichen ebenen Boden vorzusehen, wobei wiederum zur lokalen Schwächung der Oberflächenspannung der Boden vorzugsweise in seinem zentralen Bereich eine keramische Beschichtung aufweist, und eventuell zusätzlich der Boden der Glasampulle, insbesondere in seinem zentralen Bereich, eine im Vergleich zur Wandstärke der Glasampulle verminderte, vorzugsweise um 30 bis 60% verringerte, Wandstärke aufweisen kann.Within the scope of the invention, it is also possible to use glass ampoules with an to provide essential flat ground, again for local weakening the surface tension of the soil preferably in its central Area has a ceramic coating, and possibly also the Bottom of the glass ampoule, especially in its central area, one in comparison reduced to the wall thickness of the glass ampoule, preferably by 30 to 60% reduced wall thickness.
Die Erfindung wird im Folgenden anhand von Zeichnungen näher erläutert. Es zeigen:
- Fig. 1a
- eine erfindungsgemäße Ampulle in einem teilweisen Axialschnitt,
- Fig.
- 1b eine Draufsicht auf den Bodenbereich der Ampulle nach Fig. 1a sowie die
- Fig.
- 2a bis 4a bzw. 2b bis 4b Ausführungsvarianten der erfindungsgemäßen Ampulle.
- Fig. 1a
- an ampoule according to the invention in a partial axial section,
- FIG.
- 1b is a plan view of the bottom area of the ampoule according to FIG. 1a and the
- FIG.
- 2a to 4a or 2b to 4b variants of the ampoule according to the invention.
Die in Fig. 1a dargestellte Glasampulle 1 zur Aufnahme einer Flüssigkeit weist
einen zur Innenseite der Ampulle eingezogenen Bodenbereich 2 auf. Der zylindrische
Schaftbereich 3 der Ampulle 1 geht in einen Halsbereich 4 und dieser in
einen Kopfbereich 5 über. Die Bereiche 3 bis 4 können im wesentlichen beliebig
ausgeführt sein, es muss lediglich gewährleistet sein, dass die Ampulle in ein
Gerät zur automatischen Entnahme der Ampullenflüssigkeit - wie dies beispielsweise
aus der EP 0 694 498 B1 bekannt ist - eingesetzt werden kann.The
Der Bodenbereich 2 der Ampulle gemäß Fig. 1a weist eine konische Vertiefung
auf, welche im Zentrum des eingezogenen Bereiches 2 eine punktförmige keramische
Beschichtung 7 aufweist (siehe auch Fig. 1b).The
Die Ausführung gemäß Fig. 2a und 2b weist im Bodenbereich 2 eine asymmetrische,
konische Vertiefung 6' mit verminderter Wandstärke auf, wodurch ein mittig
in Richtung der Achse 1' der Ampulle angreifendes Entnahmeelement 12 einen
verringerten mechanischen Widerstand beim Öffnen des Bodens vorfindet. Wie
aus Fig. 2b ersichtlich, ist hier auch die keramische Beschichtung 7 asymmetrisch,
nämlich an der tiefsten Stelle der konischen Vertiefung 6' angeordnet. The embodiment according to FIGS. 2a and 2b has an asymmetrical,
conical recess 6 'with reduced wall thickness, which means a central
in the direction of the axis 1 'of the ampoule removal element 12 a
reduced mechanical resistance when opening the floor. How
2b, the
Bei der Ausführung gemäß Fig. 3a und 3b ist der Bodenbereich 2 der Ampulle 1
mit einer im wesentlichen zylindrischen Vertiefung 8 ausgeführt, welche einen
ebenen oder leicht gewölbten Boden 9 aufweist. Die Wandstärke des eingezogenen
Bodenbereiches 2 kann zur Gänze bzw. auch nur in einem zentralen Bereich
eine im Vergleich zur Wandstärke der Glasampulle 1 verminderte Wandstärke
aufweisen.3a and 3b, the
In den Fig. 4a und 4b ist eine Ausführungsvariante einer Glasampulle 1 dargestellt,
welche einen im wesentlichen ebenen Boden 10 aufweist, wobei dieser zur
Gänze bzw. in seinem zentralen Bereich zum leichteren Eindringen des Entnahmeelementes
eine verringerte Wandstärke (30 - 60%)aufweist. Derartige Böden
können beispielsweise auf den Schaft der Ampulle aufgeschweißt bzw. aufgeschmolzen
werden. Zusätzlich kann auch hier im zentralen Bereich eine keramische
Beschichtung 7 in Form eines Keramikpunktes aufgetragen sein. Es ist auch
möglich, dass der Bodenbereich bzw. der Boden 10 der Glasampulle 1 eine Anritzung,
vorzugsweise eine kreisförmige Anritzung 12 aufweist.4a and 4b, an embodiment variant of a
Weiters kann in allen Ausführungsvarianten eine in Fig. 4a angedeutete Elastomerbeschichtung
11 vorgesehen sein, welche auf einen an den Boden 10 (bzw.
Bodenbereich 2) der Glasampulle 1 anschließenden zylindrischen Schaftbereich 3
aufgebracht ist. Diese Elastomerbeschichtung dient dazu, allfällig Splitter im
unteren Schaftbereich festzuhalten.Furthermore, an elastomer coating indicated in FIG. 4a can be used in all
Claims (7)
- Glass ampoule (1) for holding a liquid, preferably a drug or a liquid for calibration or quality control, with a bottom area (2) that is recessed towards the interior of the ampoule, the shape (6') of the bottom area (2) being such that a defined breaking site is provided, which can be mechanically destroyed with little use of force, characterized in that the bottom area (2), i.e., preferably the centre of the recessed area, is provided with a coating (7) made of material, such as ceramics, which gives rise to tensional forces between the coated bottom area (2) and the coating (7).
- Glass ampoule (1) according to claim 1, characterized in that the bottom area (2) exhibits an asymmetrical, conical depression (6') whose lowest point is positioned eccentrically.
- Glass ampoule (1) according to claim 2, characterized in that the recessed bottom area (2) has a reduced thickness compared to the thickness of the ampoule wall, i.e., by 30 to 60 percent, preferably.
- Glass ampoule (1) for holding a liquid, such as a drug or a liquid for calibration or quality control, with an essentially flat bottom (10), characterized in that the bottom (10) is provided in its centre area with a coating (7) made of material, such as ceramics, which gives rise to tensional forces between the bottom (10) and the coating (7).
- Glass ampoule according to claim 4, characterized in that the ampoule bottom (10), in particular in its centre area, has a reduced thickness compared to the thickness of the ampoule wall, i.e., by 30 to 60 percent, preferably.
- Glass ampoule according to claim 4, characterized in that the bottom (10) of the glass ampoule (1) is provided with a slight cut, preferably a circular cut (12).
- Glass ampoule according to any of claims 2 to 6, characterized in that the cylindrical wall area (3) adjacent to the bottom area (2) or the bottom (10) of the glass ampoule (1) is provided with an elastomer coating (11).
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE59706326T DE59706326D1 (en) | 1997-11-24 | 1997-11-24 | Glass ampoule for holding a liquid |
| EP97890231A EP0919215B1 (en) | 1997-11-24 | 1997-11-24 | Glass ampule for holding a liquid |
| US09/000,948 US5948366A (en) | 1997-11-24 | 1997-12-30 | Glass ampoule for holding a drug a calibration liquid or a quality control liquid |
| JP10332133A JP3062687B2 (en) | 1997-11-24 | 1998-11-24 | Glass ampules for chemicals, calibration fluids or quality control fluids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97890231A EP0919215B1 (en) | 1997-11-24 | 1997-11-24 | Glass ampule for holding a liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0919215A1 EP0919215A1 (en) | 1999-06-02 |
| EP0919215B1 true EP0919215B1 (en) | 2002-02-06 |
Family
ID=8231126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97890231A Expired - Lifetime EP0919215B1 (en) | 1997-11-24 | 1997-11-24 | Glass ampule for holding a liquid |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5948366A (en) |
| EP (1) | EP0919215B1 (en) |
| JP (1) | JP3062687B2 (en) |
| DE (1) | DE59706326D1 (en) |
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| US6340097B1 (en) | 1998-10-22 | 2002-01-22 | Closure Medical Corporation | Applicator with protective barrier |
| US20060042373A1 (en) * | 2004-08-25 | 2006-03-02 | Kirollos Kirollos S | Smoke generating device |
| JP4866852B2 (en) * | 2004-09-08 | 2012-02-01 | ザ ダイアル コーポレイション | Method and apparatus for low cost vapor distribution device |
| WO2009149324A2 (en) * | 2008-06-06 | 2009-12-10 | Capitol Plastic Products, L.L.C. | Rack with vial |
| DE102009013211B4 (en) | 2009-03-17 | 2012-04-19 | Aap Biomaterials Gmbh | Bone cement vacuum mixing device and method for mixing bone cement |
| DE102011112516B4 (en) * | 2011-09-07 | 2024-02-29 | Stryker European Operations Holdings Llc | Container with a container for holding a liquid and a liquid removal device |
| EP3647781B1 (en) | 2018-10-29 | 2024-05-01 | EXIAS Medical GmbH | Measuring cartridge for measuring a liquid sample |
| JP2024503735A (en) | 2021-01-20 | 2024-01-26 | ロレアル | glass syringe dropper |
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| ES8504055A1 (en) * | 1983-03-10 | 1985-04-16 | Dehais Claude | selfbreakable ampoules with such a ring. |
| SE8505542L (en) * | 1985-11-25 | 1987-05-26 | Vestsvensk Medicinteknik Ab | DEVICE FOR REPLACING AMPULS |
| US5179024A (en) * | 1991-05-30 | 1993-01-12 | Harald Dahms | Sealed vials containing improved karl fischer solutions, and process for water determination using these vials |
| US5221311A (en) * | 1992-01-10 | 1993-06-22 | Rising Peter E | Evacuated sampling vial |
| AT404827B (en) * | 1994-07-28 | 1999-03-25 | Avl Verbrennungskraft Messtech | METHOD AND DEVICE FOR REMOVING A LIQUID FROM A SEALED GLASS AMULET |
-
1997
- 1997-11-24 EP EP97890231A patent/EP0919215B1/en not_active Expired - Lifetime
- 1997-11-24 DE DE59706326T patent/DE59706326D1/en not_active Expired - Lifetime
- 1997-12-30 US US09/000,948 patent/US5948366A/en not_active Expired - Lifetime
-
1998
- 1998-11-24 JP JP10332133A patent/JP3062687B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0919215A1 (en) | 1999-06-02 |
| DE59706326D1 (en) | 2002-03-21 |
| JPH11221266A (en) | 1999-08-17 |
| US5948366A (en) | 1999-09-07 |
| JP3062687B2 (en) | 2000-07-12 |
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