EP0914611A4 - Transaktivierung von leptin - Google Patents

Transaktivierung von leptin

Info

Publication number
EP0914611A4
EP0914611A4 EP97924507A EP97924507A EP0914611A4 EP 0914611 A4 EP0914611 A4 EP 0914611A4 EP 97924507 A EP97924507 A EP 97924507A EP 97924507 A EP97924507 A EP 97924507A EP 0914611 A4 EP0914611 A4 EP 0914611A4
Authority
EP
European Patent Office
Prior art keywords
leptin assay
leptin
assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97924507A
Other languages
English (en)
French (fr)
Other versions
EP0914611A1 (de
Inventor
Charles I Rosenblum
Der Ploeg Leonardus Van
Sajjad A Qureshi
Doris F Cully
John W Hess
Michael R Tota
Fang Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9611785.8A external-priority patent/GB9611785D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0914611A1 publication Critical patent/EP0914611A1/de
Publication of EP0914611A4 publication Critical patent/EP0914611A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP97924507A 1996-04-22 1997-04-18 Transaktivierung von leptin Withdrawn EP0914611A4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US1605196P 1996-04-22 1996-04-22
US16051P 1996-04-22
GBGB9611785.8A GB9611785D0 (en) 1996-06-06 1996-06-06 Leptin assay
GB9611785 1996-06-06
US3100296P 1996-11-15 1996-11-15
US31002P 1996-11-15
PCT/US1997/006505 WO1997040380A1 (en) 1996-04-22 1997-04-18 Leptin assay

Publications (2)

Publication Number Publication Date
EP0914611A1 EP0914611A1 (de) 1999-05-12
EP0914611A4 true EP0914611A4 (de) 2002-10-16

Family

ID=27268306

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97924507A Withdrawn EP0914611A4 (de) 1996-04-22 1997-04-18 Transaktivierung von leptin

Country Status (4)

Country Link
EP (1) EP0914611A4 (de)
JP (1) JP2000511406A (de)
CA (1) CA2252443A1 (de)
WO (1) WO1997040380A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6310034B1 (en) 1993-05-21 2001-10-30 Ut-Battelle, Llc Agouti polypeptide compositions
US6001968A (en) * 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US7148004B1 (en) 1997-01-16 2006-12-12 The Rockefeller University Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight
US7063958B1 (en) 1996-01-16 2006-06-20 The Rockefeller University Nucleic acids db, the receptor for leptin
US7084252B1 (en) 1996-01-16 2006-08-01 The Rockefeller University DB, the receptor for leptin
US7619079B2 (en) 1996-02-14 2009-11-17 The Rockefeller University Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
EP0951564A1 (de) * 1996-11-01 1999-10-27 Smithkline Beecham Plc Verfahren zum nachweis zur modulation der effekte vom obesitäts-(ob)-protein
WO2000007014A2 (en) * 1998-07-28 2000-02-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Leptin-mediated gene-induction
IL132313A0 (en) 1999-10-11 2001-03-19 Yeda Res & Dev Leptin assay

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US5643748A (en) * 1994-09-14 1997-07-01 Progenitor, Inc. HU-B1.219, a novel human hematopoietin receptor
AU715215B2 (en) * 1995-05-30 2000-01-20 Smithkline Beecham Plc Method for the detection of compounds that modulate the effects of the obese protein

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DARNELL J E ET AL: "JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 264, 3 June 1994 (1994-06-03), pages 1415 - 1421, XP000602106, ISSN: 0036-8075 *
DW GONG, S BI, RE PRATLEY, BD WEINTRAUB: "genomic structure and promoter analysis of the human obese gene", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 8, 1996, pages 3971 - 3974, XP002208626 *
JAMES N. IHLE: "Cytokine receptor signalling", NATURE, vol. 377, 1995, pages 591 - 594, XP001093912 *
LA BROUSSE ET AL: "Identification of the promoter of the mouse obese gene", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 30 April 1996 (1996-04-30), pages 4096 - 4101, XP002110083, ISSN: 0027-8424 *
MIYAMOTO ET AL: "REGULATED EXPRESSION OF A GENE ENCODING A NUCLEAR FACTOR, IRF-1, THAT SPECIFICALLY BINDS TO IFN-BETA GENE REGULATORY ELEMENTS", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 54, 1988, pages 903 - 913, XP002101356, ISSN: 0092-8674 *
See also references of WO9740380A1 *
Y. HE, H. CHEN, M.J. QUON, M. REITMAN: "the mouse obese gene", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 48, 1995, pages 28887 - 28891, XP002208627 *

Also Published As

Publication number Publication date
JP2000511406A (ja) 2000-09-05
CA2252443A1 (en) 1997-10-30
EP0914611A1 (de) 1999-05-12
WO1997040380A1 (en) 1997-10-30

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