EP0911398A3 - Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease - Google Patents

Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease Download PDF

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Publication number
EP0911398A3
EP0911398A3 EP98121175A EP98121175A EP0911398A3 EP 0911398 A3 EP0911398 A3 EP 0911398A3 EP 98121175 A EP98121175 A EP 98121175A EP 98121175 A EP98121175 A EP 98121175A EP 0911398 A3 EP0911398 A3 EP 0911398A3
Authority
EP
European Patent Office
Prior art keywords
tau protein
epitopes
alzheimer
diagnosis
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98121175A
Other languages
German (de)
French (fr)
Other versions
EP0911398A2 (en
EP0911398B1 (en
Inventor
Eva-Maria Mandelkow
Eckhard Mandelkow
Gerard Drewes
Jacek Biemat
Birgit Lichtenberg-Kraag
Barbara Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26129111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0911398(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP91120974A external-priority patent/EP0544942A1/en
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to EP98121175A priority Critical patent/EP0911398B1/en
Priority to EP08010527A priority patent/EP2009104A1/en
Publication of EP0911398A2 publication Critical patent/EP0911398A2/en
Publication of EP0911398A3 publication Critical patent/EP0911398A3/en
Application granted granted Critical
Publication of EP0911398B1 publication Critical patent/EP0911398B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)

Abstract

The invention relates to epitopes of the tau protein which are specifically occurring in a phoshorylated state in tau protein from Alzheimer paired helical filaments, to the use of protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to diagnostic compositions and methods for the diagnosis and/or monitoring of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein.
EP98121175A 1991-12-06 1992-12-07 Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease Expired - Lifetime EP0911398B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98121175A EP0911398B1 (en) 1991-12-06 1992-12-07 Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease
EP08010527A EP2009104A1 (en) 1991-12-06 1992-12-07 Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP91120974A EP0544942A1 (en) 1991-12-06 1991-12-06 Novel tools for the diagnosis and treatment of Alzheimer disease
EP91120974 1991-12-06
EP92119551 1992-11-16
EP92119551 1992-11-16
EP98121175A EP0911398B1 (en) 1991-12-06 1992-12-07 Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease
EP93901671A EP0618968B1 (en) 1991-12-06 1992-12-07 Tools for the diagnosis and treatment of alzheimer's disease

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP93901671A Division EP0618968B1 (en) 1991-12-06 1992-12-07 Tools for the diagnosis and treatment of alzheimer's disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP08010527A Division EP2009104A1 (en) 1991-12-06 1992-12-07 Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease

Publications (3)

Publication Number Publication Date
EP0911398A2 EP0911398A2 (en) 1999-04-28
EP0911398A3 true EP0911398A3 (en) 2003-02-26
EP0911398B1 EP0911398B1 (en) 2008-06-11

Family

ID=26129111

Family Applications (5)

Application Number Title Priority Date Filing Date
EP98121177A Expired - Lifetime EP0909814B1 (en) 1991-12-06 1992-12-07 Use of protein kinases for the diagnosis and treatment of Alzheimer's disease
EP98121175A Expired - Lifetime EP0911398B1 (en) 1991-12-06 1992-12-07 Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease
EP08010527A Withdrawn EP2009104A1 (en) 1991-12-06 1992-12-07 Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease
EP93901671A Revoked EP0618968B1 (en) 1991-12-06 1992-12-07 Tools for the diagnosis and treatment of alzheimer's disease
EP98121176A Expired - Lifetime EP0911390B1 (en) 1991-12-06 1992-12-07 Protein kinases as tools for the diagnosis and treatment of Alzheimer's disease

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP98121177A Expired - Lifetime EP0909814B1 (en) 1991-12-06 1992-12-07 Use of protein kinases for the diagnosis and treatment of Alzheimer's disease

Family Applications After (3)

Application Number Title Priority Date Filing Date
EP08010527A Withdrawn EP2009104A1 (en) 1991-12-06 1992-12-07 Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease
EP93901671A Revoked EP0618968B1 (en) 1991-12-06 1992-12-07 Tools for the diagnosis and treatment of alzheimer's disease
EP98121176A Expired - Lifetime EP0911390B1 (en) 1991-12-06 1992-12-07 Protein kinases as tools for the diagnosis and treatment of Alzheimer's disease

Country Status (10)

Country Link
US (2) US6200768B1 (en)
EP (5) EP0909814B1 (en)
JP (4) JPH07507044A (en)
AT (4) ATE398176T1 (en)
AU (2) AU681071B2 (en)
CA (1) CA2125298A1 (en)
DE (4) DE69230148T2 (en)
DK (1) DK0618968T3 (en)
ES (2) ES2302343T3 (en)
WO (1) WO1993011231A1 (en)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010913A (en) * 1992-12-14 2000-01-04 N.V. Innogenetics S.A. Isolated human tau peptide
JPH06239899A (en) * 1993-02-12 1994-08-30 Teijin Ltd Antibody for human tau protein and determination of human tau protein in body fluid utilizing the same
GB2295395B (en) * 1993-08-12 1998-04-01 Inst Of Psychiatry Models of Alzheimer's disease
GB9316727D0 (en) * 1993-08-12 1993-09-29 Inst Of Psychiatry Models of alzheimers's disease
CA2178212C (en) * 1993-12-21 2011-06-14 Marc Vandermeeren Monoclonal antibodies specific for phf-tau, hybridomas secreting them, antigen recognition by these antibodies and their applications
WO1996004309A1 (en) * 1994-07-29 1996-02-15 Innogenetics N.V. Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications
GB9506197D0 (en) * 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
US6265150B1 (en) 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
GB9610829D0 (en) 1996-05-23 1996-07-31 Medical Res Council Screening of agents for treatment of azlheimers disease
EP1009853B1 (en) * 1997-09-04 2006-04-26 The Board Of Trustees Of The Leland Stanford Junior University Assays for detecting modulators of cytoskeletal function
US7252950B1 (en) 1997-09-04 2007-08-07 The Regents Of The University Of California Assays for detecting modulators of cytoskeletal function
US6797478B1 (en) * 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
AR023052A1 (en) 1998-09-25 2002-09-04 Mitsuharu Yoshimura Milton DERIVATIVES OF PIRIMIDONA
US20020002270A1 (en) * 1999-06-16 2002-01-03 Raymond P. Zinkowski Purified antigen for alzheimer's disease, and methods of obtaining and using same
US7640062B2 (en) 2000-05-08 2009-12-29 Brainsgate Ltd. Methods and systems for management of alzheimer's disease
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
US20030162230A1 (en) 2000-09-27 2003-08-28 Reagan Kevin J. Method for quantifying phosphokinase activity on proteins
GB0100119D0 (en) 2001-01-03 2001-02-14 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
KR100960256B1 (en) 2001-02-27 2010-06-01 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
EP1925315A3 (en) * 2001-02-27 2009-11-18 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0117326D0 (en) 2001-07-16 2001-09-05 Univ Aberdeen Napthoquinone-type inhibitors of protein aggregation
KR100754596B1 (en) 2001-09-21 2007-09-05 미쯔비시 웰 파마 가부시키가이샤 3-substituted-4-pyrimidone derivatives
CA2460121C (en) 2001-09-21 2010-11-02 Mitsubishi Pharma Corporation 3-substituted-4-pyrimidone derivatives
CA2477604A1 (en) * 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
US7684859B2 (en) * 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
KR20050000409A (en) * 2002-04-25 2005-01-03 브레인스게이트 리미티드 Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head
EP1585430B1 (en) * 2002-11-14 2017-01-11 Brainsgate Ltd. Surgical tools and techniques for stimulation
JP4616003B2 (en) 2002-12-16 2011-01-19 田辺三菱製薬株式会社 3-substituted-4-pyrimidone derivatives
AU2003296663A1 (en) * 2002-12-18 2004-07-09 Novartis Ag Endothelial cell specifically binding peptides
DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
GB2398533B (en) * 2003-02-19 2005-11-16 Gillette Co Safety razors
TWI357408B (en) 2003-03-26 2012-02-01 Mitsubishi Tanabe Pharma Corp 3-substituted-4-pyrimidone derivatives
WO2005058374A1 (en) * 2003-12-15 2005-06-30 Tongji Medical Center Methods and compositions for modulating tau in vivo
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8010189B2 (en) * 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US20090299418A1 (en) * 2004-08-23 2009-12-03 Brainsgate Ltd. Concurrent bilateral spg modulation
JP5186212B2 (en) 2004-09-23 2013-04-17 ウィスタ ラボラトリーズ リミテッド Method for chemical synthesis and purification of diaminophenothiazinium compounds such as methylthioninium chloride (MTC)
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
EP1843734A4 (en) * 2005-02-03 2008-09-10 Signum Biosciences Inc Compositions and methods for enhancing cognitive function
US20070134724A1 (en) * 2005-08-04 2007-06-14 Peter Davies Phosphorylation of tau by abl
US20090029873A1 (en) 2005-10-11 2009-01-29 Blanchette Rockefeller Neurosciences Institute Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb)
KR101667623B1 (en) 2005-11-30 2016-10-19 애브비 인코포레이티드 Monoclonal antibodies against amyloid beta protein and uses thereof
PL1954718T3 (en) 2005-11-30 2015-04-30 Abbvie Inc Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
DK2013191T6 (en) 2006-03-29 2019-04-23 Wista Lab Ltd 3,7-Diamino-10H-phenothiazine salts and their use
CA2645946C (en) 2006-03-29 2014-04-01 Wista Laboratories Ltd. Inhibitors of protein aggregation
US20090210026A1 (en) * 2006-08-17 2009-08-20 Brainsgate Ltd. Spg stimulation for enhancing neurogenesis and brain metabolism
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US20110086908A9 (en) * 2007-01-22 2011-04-14 Roger Nitsch Use of phosphatase inhibitors for the treatment of neurodegenerative diseases
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
EP2669386A1 (en) 2008-07-28 2013-12-04 Blanchette Rockefeller Neurosciences Institute Stimulus-elicited genomic profile markers of alzheimer's disease
ES2683021T3 (en) 2008-07-28 2018-09-24 Blanchette Rockefeller Neurosciences Institute PKC activating compounds for the treatment of neurodegenerative diseases
US9464122B2 (en) * 2008-08-20 2016-10-11 Oligomerix, Inc. Methods and compositions comprising tau oligomers
WO2010021755A2 (en) * 2008-08-20 2010-02-25 Oligomerix, Inc. Tau protease compositions and methods
FR2940972B1 (en) 2009-01-09 2015-07-31 Isp Investments Inc NOVEL ANTI-AGING PEPTIDES AND COSMETIC AND / OR PHARMACEUTICAL COMPOSITION CONTAINING SAME
EP4218794A3 (en) 2009-06-10 2023-09-13 New York University Immunological targeting of pathological tau proteins
US8609097B2 (en) * 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
NZ598356A (en) * 2009-07-30 2014-06-27 Pfizer Vaccines Llc Antigenic tau peptides and uses thereof
WO2011026031A1 (en) * 2009-08-28 2011-03-03 The Board Of Regents Of The University Of Texas System Antibodies that bind tau oligomers
US10266585B2 (en) 2009-08-28 2019-04-23 The Board Of Regents Of The Univerity Of Texas System Methods of treating brain injury
CN102549438B (en) 2009-09-24 2014-10-29 国家健康与医学研究院 FKBP52-TAU interaction as a novel therapeutical target for treating the neurological disorders involving TAU dysfunction
US20110144029A1 (en) * 2009-09-30 2011-06-16 Board Of Regents, The University Of Texas System Model Systems and Materials for the Study and Treatment of Neurodegenerative Diseases
WO2011041761A1 (en) 2009-10-02 2011-04-07 Blanchette Rockefeller Neurosciences Institute Fibroblast growth patterns for diagnosis of alzheimer's disease
MX336196B (en) 2010-04-15 2016-01-11 Abbvie Inc Amyloid-beta binding proteins.
MX358739B (en) 2010-08-14 2018-09-03 Abbvie Inc Star Amyloid-beta binding proteins.
CA2812865C (en) 2010-10-07 2021-01-26 Ac Immune S.A. Phosphospecific antibodies recognising tau
CA2817973C (en) 2010-10-15 2019-06-25 The Board Of Regents Of The University Of Texas System Antibodies that bind amyloid oligomers
CN105853439A (en) 2011-02-11 2016-08-17 维斯塔实验室有限公司 Phenothiazine diaminium salts and their use
KR20140038396A (en) 2011-04-28 2014-03-28 우니베르지태트 라이치히 Polymutant tau protein variants and their use for recapitulating human tauopathies
US9506051B2 (en) 2011-05-20 2016-11-29 Oligomerix, Inc. Tau protease compositions and methods of use
CN109265543B (en) * 2011-09-19 2022-04-26 阿克松神经系统科学公司 Protein-based therapy and diagnosis of TAU protein-mediated pathologies in alzheimer's disease
CN104080806B (en) 2011-10-07 2018-01-19 Ac免疫有限公司 Identify Tau phosphorylation specific antibody
EP2780316B1 (en) 2011-11-13 2020-04-15 Blanchette Rockefeller Neurosciences Institute Esters of dcpla and methods of treatment using the same
WO2014008404A1 (en) 2012-07-03 2014-01-09 Washington University Antibodies to tau
WO2014141124A1 (en) * 2013-03-13 2014-09-18 Institut National De La Sante Et De La Recherche Medicale Erk-pathway activating compound for preventing or treating leptin resistance
RU2661111C2 (en) 2013-03-15 2018-07-11 Ац Иммуне С.А. Anti-tau antibodies and methods of use
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
CA2932958A1 (en) 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Humanized anti-tau(ps422) antibodies and methods of use
WO2015165961A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
AR100978A1 (en) 2014-06-26 2016-11-16 Hoffmann La Roche ANTI-Tau HUMANIZED ANTIBODY BRAIN LAUNCHERS (pS422) AND USES OF THE SAME
TWI734975B (en) 2014-06-27 2021-08-01 美商Ｃ２Ｎ醫療診斷有限責任公司 Humanized anti-tau antibodies
CN107073297B (en) 2014-07-08 2021-09-14 纽约大学 Tau imaging ligands and their use in diagnosis and treatment of tauopathies
WO2016112078A2 (en) * 2015-01-08 2016-07-14 Janssen Biotech, Inc. Anti-phf-tau antibodies and their uses
US10271907B2 (en) 2015-05-13 2019-04-30 Brainsgate Ltd. Implant and delivery system for neural stimulator
PL3313877T3 (en) 2015-06-24 2020-11-02 F. Hoffmann-La Roche Ag Humanized anti-tau(ps422) antibodies and methods of use
JO3711B1 (en) 2015-07-13 2021-01-31 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
JP6913078B2 (en) 2015-08-13 2021-08-04 ニューヨーク・ユニバーシティ Antibody-based molecules specific for the shortened Asp421 epitope of tau, and their use in the diagnosis and treatment of tau dysfunction.
KR20230161532A (en) 2015-11-24 2023-11-27 메사추세츠 인스티튜트 오브 테크놀로지 Systems and methods for preventing, mitigating, and/or treating dementia
JOP20200228A1 (en) 2015-12-21 2017-06-16 Novartis Ag Compositions and methods for decreasing tau expression
PE20190227A1 (en) 2016-07-12 2019-02-13 H Lundbeck As SPECIFIC ANTIBODIES FOR HYPERPHOSPHORILATED TAU AND THEIR METHODS OF USE
US10995137B2 (en) 2017-01-04 2021-05-04 H. Lundbeck A/S Antibodies specific for hyperphosphorlated tau for the treatment of ocular diseases
KR20220146710A (en) 2017-10-10 2022-11-01 메사추세츠 인스티튜트 오브 테크놀로지 Systems and methods for preventing, mitigating, and/or treating dementia
KR20230015501A (en) * 2017-10-10 2023-01-31 메사추세츠 인스티튜트 오브 테크놀로지 Treating dementia with visual stimulation to synch gamma oscillations in brain
US10960225B2 (en) 2017-10-10 2021-03-30 Massachusetts Institute Of Technology Systems and methods for preventing, mitigating, and/or treating dementia via visual stimulation that binds higher order brain regions, reduces neurodegeneration and neuroinflammation, and improves cognitive function

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0303555A2 (en) * 1987-08-11 1989-02-15 Dr. Franz Köhler Chemie GmbH Preparation of a metallic chelate of ethanol aminophosphoric acid and medicament
WO1989003993A1 (en) * 1987-10-19 1989-05-05 Medical Research Council Paired helical filament core and antibody thereto useful in diagnosing alzheimer's disease
US4874694A (en) * 1987-04-07 1989-10-17 The Rockefeller University Use of phosphoprotein patterns for diagnosis of neurological and psychiatric disorders
EP0457295A2 (en) * 1990-05-16 1991-11-21 The Rockefeller University Use of a modulator of protein phosphorylation in the treatment of amyloidosis associated with Alzheimer's disease
WO1993003148A2 (en) * 1991-08-09 1993-02-18 Massachusetts Institute Of Technology Tau/neurofilament protein kinases pk40 and pk36
WO1996013592A2 (en) * 1994-10-28 1996-05-09 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Protein kinase npk-110

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE911869A1 (en) * 1990-06-01 1991-12-04 Regeneron Pharma A family of map2 protein kinases
DE4028970A1 (en) 1990-09-12 1992-03-19 Kettner Verpackungsmaschf TRANSPORT ROLE

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874694A (en) * 1987-04-07 1989-10-17 The Rockefeller University Use of phosphoprotein patterns for diagnosis of neurological and psychiatric disorders
EP0303555A2 (en) * 1987-08-11 1989-02-15 Dr. Franz Köhler Chemie GmbH Preparation of a metallic chelate of ethanol aminophosphoric acid and medicament
WO1989003993A1 (en) * 1987-10-19 1989-05-05 Medical Research Council Paired helical filament core and antibody thereto useful in diagnosing alzheimer's disease
EP0457295A2 (en) * 1990-05-16 1991-11-21 The Rockefeller University Use of a modulator of protein phosphorylation in the treatment of amyloidosis associated with Alzheimer's disease
WO1993003148A2 (en) * 1991-08-09 1993-02-18 Massachusetts Institute Of Technology Tau/neurofilament protein kinases pk40 and pk36
WO1996013592A2 (en) * 1994-10-28 1996-05-09 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Protein kinase npk-110

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
AIZAWA H, KAWASAKI H, MUROFUSHI H, KOTANI S, SUZUKI K, SAKAI H.: "Microtubule-binding domain of tau proteins.", J BIOL CHEM 1988 JUN 5;263(16):7703-7, XP002226001 *
BIERNAT ET AL.: "The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region", EMBO JOURNAL, vol. 11, no. 4, 4 April 1992 (1992-04-04), EYNSHAM, OXFORD GB, pages 1593 - 1597, XP001109363 *
BRION JP, HANGER DP, COUCK AM, ANDERTON BH.: "A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities.", BIOCHEM J 1991 NOV 1;279 ( PT 3):831-6, XP002226002 *
GOEDERT M ET AL: "CLONING AND SEQUENCING OF THE CDNA ENCODING A CORE PROTEIN OF THE PAIRED HELICAL FILAMENT OF ALZHEIMER DISEASE: IDENTIFICATION AS THEMICROTUBULE-ASSOCIATED PROTEIN TAU", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 85, June 1988 (1988-06-01), pages 4051 - 4055, XP002942590, ISSN: 0027-8424 *
GUSTKE N, STEINER B, MANDELKOW EM, BIERNAT J, MEYER HE, GOEDERT M, MANDELKOW E.: "The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.", FEBS LETT. 1992 JUL 28;307(2):199-205., XP001127472 *
ISHIGURO K. ET AL.: "A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope", NEUROSCIENCE LETTERS, vol. 128, July 1991 (1991-07-01), pages 195 - 198, XP001131938 *
LEDESMA M D ET AL: "IMPLICATION OF BRAIN CDC2 AND MAP2 KINASES IN THE PHOSPHORYLATION OF TAU PROTEIN IN ALZHEIMER'S DISEASE", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 308, no. 2, 17 August 1992 (1992-08-17), pages 218 - 224, XP000371843, ISSN: 0014-5793 *
LEE V M-Y ET AL: "A68: A MAJOR SUBUNIT OF PAIRED HELICAL FILAMENTS AND DERIVATIZED FORMS OF NORMAL TAU", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 251, 8 February 1991 (1991-02-08), pages 675 - 678, XP002001385, ISSN: 0036-8075 *
LICHTENBERG-KRAAG B. ET AL.: "alzheimer-type phosphorylation of microtubule -associated protein tau in vitro", THE JOURNAL OF CELL BIOLOGY., vol. 115, no. 3, 8 December 1991 (1991-12-08), LER UNIVERSITY PRESS US, pages 2, XP001131910 *
LICHTENBERG-KRAAG, B. ET AL.: "'Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, no. 12, June 1992 (1992-06-01), WASHINGTON US, pages 5384 - 5388, XP002226003 *
RODER H M ET AL: "TWO NOVEL KINASES PHOSPHORYLATE TAU AND THE KSP SITE OF HEAVY NEUROFILAMENT SUBUNITS IN HIGH STOICHIOMETRIC RATIOS", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 11, no. 11, 1 November 1991 (1991-11-01), pages 3325 - 3343, XP000579111, ISSN: 0270-6474 *
UÉDA K ET AL: "ALZ-50 RECOGNIZES A PHOSPHORYLATED EPITOPE OF TAU PROTEIN", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 10, no. 10, 1 October 1990 (1990-10-01), pages 3295 - 3304, XP000600531, ISSN: 0270-6474 *

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