EP0897283B1 - Analysis for the presence of degenerative brain disease - Google Patents
Analysis for the presence of degenerative brain disease Download PDFInfo
- Publication number
- EP0897283B1 EP0897283B1 EP97916578A EP97916578A EP0897283B1 EP 0897283 B1 EP0897283 B1 EP 0897283B1 EP 97916578 A EP97916578 A EP 97916578A EP 97916578 A EP97916578 A EP 97916578A EP 0897283 B1 EP0897283 B1 EP 0897283B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- animals
- rsa
- measure
- respiratory
- slaughter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
Definitions
- BSE bovine spongiform encephalopathy
- the invention also provides an animal carcass selection apparatus, comprising monitoring means for deriving a measure of the respiratory sinus arrhythmia of animals prior to slaughter, and means for comparing this measure with a reference value or range and hence producing an output indicating whether or not individual animals have normal RSA, the output being used to enable the selection of carcasses of only those animals for which the output indicates normal RSA.
- the paper by Genovely and Pfeifer referred to above sets out various analysis methods including the "mean circular resultant" method which relies upon the degree of clustering of R-waves relative to the respiratory cycle. This is a suitable method to be used in measuring RSA in methods in accordance with the present invention.
- RSA may also be measured in other ways, for example by fitting only an ECG monitor to the animal, and analysing the spectral components of an ECG tachygram derived from the monitor, i.e. the beat to beat variations in heart rate. RSA appears as a high frequency peak coincident with the respiratory frequency.
- the lungs 1 expand and contract as a result of normal respiration. Stretch receptors in the wall of the lungs generate signals which are transmitted over nerves represented by line 2 to the brain stem or medulla 3. Signals from the medulla are transmitted on nerves represented by the line 4 to the heart 5. Damage to the medulla will also of course disrupt the transmission of signals from the cerebral cortex 6 but damage to the cerebral cortex will not directly affect the lungs/brain/heart control loop.
- Figure 3 represents outputs which can be expected from a healthy mammal.
- the regular line 12 represents the reference level.
- the irregular line 13 represents the measured RSA. It will be noted that the two signals are of the same order of magnitude and that the signal 13 is sometimes greater than and sometime less than the reference level 12.
- Figure 4 represents outputs which can be expected from a mammal in which the lung/brain/heart control loop has been disrupted for example as a result of diabetes, anaesthesia or the formation of lesions in the brain stem.
- the line 12 remains much as it would be in a healthy subject. This indicates that good quality data is being assessed.
- the line 13 indicates a greatly suppressed RSA level which is substantially constant over time. The two cases illustrated in Figures 3 and 4 are clearly distinguishable.
- ECG electrocardiogram
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Physiology (AREA)
- Cardiology (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Child & Adolescent Psychology (AREA)
- Developmental Disabilities (AREA)
- Hospice & Palliative Care (AREA)
- Signal Processing (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Neurosurgery (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (9)
- A method for selecting mammalian animal carcasses for introduction into the human food chain, wherein before slaughter the respiratory sinus arrhythmia of the animals to be slaughtered is measured, and only those carcasses from animals for which the associated RSA is normal are selected.
- A method according to claim 1, wherein animals are selected if the RSA is within a predetermined range.
- A method for selecting mammalian animals for slaughter, wherein the respiratory sinus arrhythmia of the animals is assessed, and animals with an abnormal measured RSA are slaughtered.
- A method according to claim 3, wherein animals are selected if the measured RSA is outside a predetermined range.
- A method according to any preceding claim, wherein a measure of RSA is computed by analysing the degree of clustering of a series of R-waves relative to the respiratory cycles in which they occur, a test for randomness is applied to the analysed series of R-waves to derive a reference value representing a predetermined significance level for clustering of the R-waves relative to the respiratory cycles, and the measurement value is compared with the reference value, a substantial difference between the compared values leading to the assumption that the mammal is suffering from a degenerative brain disease.
- A method according to any one of claims 1 to 4, wherein a measure of RSA is computed by analysing an ECG tachygram to detect high frequency peaks coincident with the respiratory frequency.
- An animal carcass selection apparatus, comprising monitoring means for deriving a measure of the respiratory sinus arrhythmia of animals prior to slaughter, and means for comparing this measure with a reference value or range and hence producing an output indicating whether or not individual animals have normal RSA, the output being used to enable the selection of carcasses of only those animals for which the output indicates normal RSA.
- A selection apparatus for selecting animals for slaughter, comprising monitoring means for deriving a measure of the respiratory sinus arrhythmia of the animals, and means for comparing this measure with a reference value or range and hence producing an output indicating which animals have an abnormal measured RSA to enable the slaughter of such animals.
- An apparatus according to claim 7 or 8, comprising an ECG monitor, and a breathing monitor.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK97916578T DK0897283T3 (en) | 1996-04-17 | 1997-04-15 | Analysis for the presence of degenerative brain disease |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9607970 | 1996-04-17 | ||
GB9607970A GB9607970D0 (en) | 1996-04-17 | 1996-04-17 | Analysis for the presence of degenerative brain diseasse |
GB9623759A GB9623759D0 (en) | 1996-11-15 | 1996-11-15 | Analysis for the presence of degenerative brain disease |
GB9623759 | 1996-11-15 | ||
GB9704300 | 1997-03-01 | ||
GB9704300A GB9704300D0 (en) | 1997-03-01 | 1997-03-01 | Analysis for the presence of degenerative brain disease |
PCT/GB1997/001043 WO1997038627A1 (en) | 1996-04-17 | 1997-04-15 | Analysis for the presence of degenerative brain disease |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0897283A1 EP0897283A1 (en) | 1999-02-24 |
EP0897283B1 true EP0897283B1 (en) | 2004-10-13 |
Family
ID=27268245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97916578A Expired - Lifetime EP0897283B1 (en) | 1996-04-17 | 1997-04-15 | Analysis for the presence of degenerative brain disease |
Country Status (11)
Country | Link |
---|---|
US (1) | US6217521B1 (en) |
EP (1) | EP0897283B1 (en) |
JP (1) | JP2001502193A (en) |
AT (1) | ATE279143T1 (en) |
AU (1) | AU736454B2 (en) |
CA (1) | CA2251831A1 (en) |
DE (1) | DE69731194T2 (en) |
DK (1) | DK0897283T3 (en) |
ES (1) | ES2230599T3 (en) |
PT (1) | PT897283E (en) |
WO (1) | WO1997038627A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624280D0 (en) | 1996-11-22 | 1997-01-08 | Univ Glasgow | Apparatus and method for measuring cardiac vagal tone |
US6591991B2 (en) * | 2001-08-06 | 2003-07-15 | Luce Belle | Collapsible tire stand |
US20030092090A1 (en) * | 2001-11-14 | 2003-05-15 | Kiamars Hajizadeh | Rapid prion-detection device, system, and test kit |
US7045297B2 (en) * | 2001-11-14 | 2006-05-16 | Prion Developmental Laboratories, Inc. | Rapid prion-detection assay |
GB2399886A (en) * | 2003-03-26 | 2004-09-29 | Secr Defence | Identifying degenerative brain disease using EEG or EMG measurements |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4510944A (en) * | 1982-12-30 | 1985-04-16 | Porges Stephen W | Method and apparatus for evaluating rhythmic oscillations in aperiodic physiological response systems |
GB9022623D0 (en) * | 1990-10-18 | 1990-11-28 | Univ Manchester | Depth of anaesthesia monitoring |
GB9307523D0 (en) * | 1993-04-13 | 1993-06-02 | Mini Agriculture & Fisheries | Detection of cns gases |
-
1997
- 1997-04-15 ES ES97916578T patent/ES2230599T3/en not_active Expired - Lifetime
- 1997-04-15 JP JP09536867A patent/JP2001502193A/en not_active Ceased
- 1997-04-15 PT PT97916578T patent/PT897283E/en unknown
- 1997-04-15 AT AT97916578T patent/ATE279143T1/en not_active IP Right Cessation
- 1997-04-15 WO PCT/GB1997/001043 patent/WO1997038627A1/en active IP Right Grant
- 1997-04-15 CA CA002251831A patent/CA2251831A1/en not_active Abandoned
- 1997-04-15 AU AU25189/97A patent/AU736454B2/en not_active Ceased
- 1997-04-15 DE DE69731194T patent/DE69731194T2/en not_active Expired - Fee Related
- 1997-04-15 EP EP97916578A patent/EP0897283B1/en not_active Expired - Lifetime
- 1997-04-15 DK DK97916578T patent/DK0897283T3/en active
-
1998
- 1998-10-16 US US09/173,736 patent/US6217521B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE279143T1 (en) | 2004-10-15 |
AU736454B2 (en) | 2001-07-26 |
EP0897283A1 (en) | 1999-02-24 |
DE69731194D1 (en) | 2004-11-18 |
AU2518997A (en) | 1997-11-07 |
PT897283E (en) | 2005-02-28 |
CA2251831A1 (en) | 1997-10-23 |
DK0897283T3 (en) | 2005-02-14 |
US6217521B1 (en) | 2001-04-17 |
WO1997038627A1 (en) | 1997-10-23 |
JP2001502193A (en) | 2001-02-20 |
DE69731194T2 (en) | 2005-10-20 |
ES2230599T3 (en) | 2005-05-01 |
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