EP0894003A4 - N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors - Google Patents
N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitorsInfo
- Publication number
- EP0894003A4 EP0894003A4 EP97917889A EP97917889A EP0894003A4 EP 0894003 A4 EP0894003 A4 EP 0894003A4 EP 97917889 A EP97917889 A EP 97917889A EP 97917889 A EP97917889 A EP 97917889A EP 0894003 A4 EP0894003 A4 EP 0894003A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitors
- containing compounds
- compounds useful
- nep
- formyl hydroxylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1629596P | 1996-04-12 | 1996-04-12 | |
US16295P | 1996-04-12 | ||
PCT/US1997/005744 WO1997038705A1 (en) | 1996-04-12 | 1997-04-07 | N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0894003A1 EP0894003A1 (en) | 1999-02-03 |
EP0894003A4 true EP0894003A4 (en) | 2000-10-04 |
Family
ID=21776392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97917889A Withdrawn EP0894003A4 (en) | 1996-04-12 | 1997-04-07 | N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0894003A4 (en) |
JP (1) | JP2000511882A (en) |
AU (1) | AU715451B2 (en) |
CA (1) | CA2251292A1 (en) |
WO (1) | WO1997038705A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
WO1999039704A1 (en) | 1998-02-07 | 1999-08-12 | British Biotech Pharmaceuticals Limited | Antibacterial agents |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
US6569851B1 (en) | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6774125B2 (en) | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
GB9827805D0 (en) | 1998-12-16 | 1999-02-10 | British Biotech Pharm | Antibacterial agents |
GB9907055D0 (en) | 1999-03-29 | 1999-05-19 | British Biotech Pharm | Antibacterial agents |
DE69924887T2 (en) * | 1999-08-10 | 2006-03-09 | Vernalis (Oxford) Ltd., Abington | ANTIBACTERIAL AGENTS |
US6509330B2 (en) | 2000-02-17 | 2003-01-21 | Bristol-Myers Squibb Company | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors |
DE10020818A1 (en) | 2000-04-28 | 2001-10-31 | Degussa | 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for their preparation and their use |
WO2016191178A1 (en) | 2015-05-22 | 2016-12-01 | Biotheryx, Inc. | Compounds targeting proteins, compositions, methods, and uses thereof |
WO2017201069A1 (en) | 2016-05-18 | 2017-11-23 | Biotheryx, Inc. | Oxoindoline derivatives as protein function modulators |
US10882867B2 (en) * | 2017-03-16 | 2021-01-05 | Celgene Car Llc | Forms and compositions of a MK2 inhibitor |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0236872A2 (en) * | 1986-03-11 | 1987-09-16 | F. Hoffmann-La Roche Ag | Hydroxyl amine derivatives, their preparation and use as medicaments |
EP0524553A1 (en) * | 1991-07-23 | 1993-01-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Acylmercaptoalkanoyldipeptides, methods of preparation and their therapeutic use |
EP0599444A1 (en) * | 1992-05-18 | 1994-06-01 | E.R. SQUIBB & SONS, INC. | Dual action inhibitors |
EP0655461A1 (en) * | 1993-11-16 | 1995-05-31 | Ciba-Geigy Ag | Cyclic amino acid derivatives having ACE and NEP inhibiting activity |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4539150A (en) * | 1983-06-29 | 1985-09-03 | Mitsui Toatsu Chemicals, Inc. | Benzothiazepine derivatives and their methods of preparation |
US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
-
1997
- 1997-04-07 WO PCT/US1997/005744 patent/WO1997038705A1/en not_active Application Discontinuation
- 1997-04-07 JP JP09537168A patent/JP2000511882A/en active Pending
- 1997-04-07 AU AU26094/97A patent/AU715451B2/en not_active Ceased
- 1997-04-07 EP EP97917889A patent/EP0894003A4/en not_active Withdrawn
- 1997-04-07 CA CA002251292A patent/CA2251292A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0236872A2 (en) * | 1986-03-11 | 1987-09-16 | F. Hoffmann-La Roche Ag | Hydroxyl amine derivatives, their preparation and use as medicaments |
EP0524553A1 (en) * | 1991-07-23 | 1993-01-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Acylmercaptoalkanoyldipeptides, methods of preparation and their therapeutic use |
EP0599444A1 (en) * | 1992-05-18 | 1994-06-01 | E.R. SQUIBB & SONS, INC. | Dual action inhibitors |
EP0655461A1 (en) * | 1993-11-16 | 1995-05-31 | Ciba-Geigy Ag | Cyclic amino acid derivatives having ACE and NEP inhibiting activity |
Non-Patent Citations (4)
Title |
---|
FOURNIE-ZALUSKI M -C ET AL: "NEW BIDENTATES AS FULL INHIBITORS OF ENKEPHALIN-DEGRADING ENZYMES: SYNTHESIS AND ANALGESIC PROPERTIES", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 28, no. 9, 1985, pages 1158 - 1169, XP000906979, ISSN: 0022-2623 * |
NISHINO E.A.: "DESIGN OF POTENT REVERSIBLE INHIBITORS OF THERMOLYSIN. PEPTIDES CONTAINING ZINC COORDINATING LIGANDS AND THEIR USE IN AFFINITY CHROMATOGRAPHY", BIOCHEMISTRY, vol. 18, no. 20, 1979, EASTON, PA US, pages 4340 - 4347, XP002144002 * |
See also references of WO9738705A1 * |
WELLER E.A.: "Design of conformationally constrained angiotensin-converting-enzyme inhibitors", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 125, no. 1, 1984, ORLANDO, FL US, pages 82 - 89, XP000915405 * |
Also Published As
Publication number | Publication date |
---|---|
JP2000511882A (en) | 2000-09-12 |
WO1997038705A1 (en) | 1997-10-23 |
CA2251292A1 (en) | 1997-10-23 |
AU2609497A (en) | 1997-11-07 |
EP0894003A1 (en) | 1999-02-03 |
AU715451B2 (en) | 2000-02-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19981005 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 61K 38/05 A, 7C 07K 5/02 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20000818 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20030602 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060725 |