EP0869780A4 - Method for inhibiting generation of free-radicals - Google Patents

Method for inhibiting generation of free-radicals

Info

Publication number
EP0869780A4
EP0869780A4 EP95943790A EP95943790A EP0869780A4 EP 0869780 A4 EP0869780 A4 EP 0869780A4 EP 95943790 A EP95943790 A EP 95943790A EP 95943790 A EP95943790 A EP 95943790A EP 0869780 A4 EP0869780 A4 EP 0869780A4
Authority
EP
European Patent Office
Prior art keywords
radicals
free
inhibiting generation
inhibiting
generation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95943790A
Other languages
German (de)
French (fr)
Other versions
EP0869780A1 (en
Inventor
Ronald T Stanko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/286,946 external-priority patent/US5480909A/en
Application filed by Individual filed Critical Individual
Publication of EP0869780A1 publication Critical patent/EP0869780A1/en
Publication of EP0869780A4 publication Critical patent/EP0869780A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
EP95943790A 1994-08-08 1995-12-11 Method for inhibiting generation of free-radicals Withdrawn EP0869780A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/286,946 US5480909A (en) 1994-08-08 1994-08-08 Method for inhibiting generation of free-radicals
PCT/US1995/016257 WO1997021433A1 (en) 1994-08-08 1995-12-11 Method for inhibiting generation of free-radicals
CN95198020.3A CN1209742A (en) 1994-08-08 1995-12-11 Method for inhibiting generation of free-radicals
CA002245509A CA2245509A1 (en) 1994-08-08 1995-12-11 Method for inhibiting generation of free-radicals

Publications (2)

Publication Number Publication Date
EP0869780A1 EP0869780A1 (en) 1998-10-14
EP0869780A4 true EP0869780A4 (en) 1999-03-03

Family

ID=27427458

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95943790A Withdrawn EP0869780A4 (en) 1994-08-08 1995-12-11 Method for inhibiting generation of free-radicals

Country Status (3)

Country Link
EP (1) EP0869780A4 (en)
AU (1) AU4517696A (en)
WO (1) WO1997021433A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2694592A (en) * 1991-09-30 1993-05-03 Walser, Mackenzie Methods for treatment of free-radical-mediated tissue injury

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DEBOER L W V ET AL: "PYRUVATE ENHANCES RECOVERY OF RAT HEARTS AFTER ISCHEMIA AND REPERFUSION BY PREVENTING FREE RADICAL GENERATION", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 265, no. 5, PART 02, November 1993 (1993-11-01), pages 1571 - 1576, XP000602421 *
GROOT DE M J M ET AL: "THE INFLUENCE OF LACTATE, PYRUVATE AND GLUCOSE AS EXOGENOUS SUBSTRATES ON FREE RADICAL DEFENSE MECHANISMS IN ISOLATED RAT HEARTS DURING ISCHAEMIA AND REPERFUSION", MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 146, no. 2, 24 May 1995 (1995-05-24), pages 147 - 155, XP000602431 *
KARL A. NATH ET AL: "EFFECT OF PYRUVATE ON OXIDANT INJURY TO ISOLATED AND CELLULAR DNA", KIDNEY INTERNATIONAL, vol. 45, no. 1, January 1994 (1994-01-01), pages 166 - 176, XP002089014 *
O'DONNELL-TORMEY J ET AL: "SECRETION OF PYRUVATE AN ANTIOXIDANT DEFENSE OF MAMMALIAN CELLS", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 165, no. 2, 1 February 1987 (1987-02-01), pages 500 - 514, XP000602406 *
See also references of WO9721433A1 *
SPENCER DASTON D ET AL: "SODIUM PYRUVATE INHIBITION OF H2O2-INDUCED MUTATION IN MAMMALIAN CELLS", ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, vol. 9, no. 8, 1987, pages 27/28, XP000613328 *
STANKO R T ET AL: "PYRUVATE INHIBITS CLORIBRATE-INDUCED HEPATIC PEROXISOMAL PROLIFERATION AND FREE RADICAL PRODUCTION IN RATS", METABOLISM, CLINICAL AND EXPERIMENTAL, vol. 44, no. 2, February 1995 (1995-02-01), pages 166 - 171, XP000602400 *

Also Published As

Publication number Publication date
AU4517696A (en) 1997-07-03
EP0869780A1 (en) 1998-10-14
WO1997021433A1 (en) 1997-06-19

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