EP0865502A4 - A fluorescence-based screening method for identifying ligands - Google Patents
A fluorescence-based screening method for identifying ligandsInfo
- Publication number
- EP0865502A4 EP0865502A4 EP96944304A EP96944304A EP0865502A4 EP 0865502 A4 EP0865502 A4 EP 0865502A4 EP 96944304 A EP96944304 A EP 96944304A EP 96944304 A EP96944304 A EP 96944304A EP 0865502 A4 EP0865502 A4 EP 0865502A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- fluorescence
- screening method
- based screening
- identifying ligands
- ligands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US834695P | 1995-12-07 | 1995-12-07 | |
| US8346P | 1995-12-07 | ||
| PCT/US1996/019698 WO1997020952A1 (en) | 1995-12-07 | 1996-12-06 | A fluorescence-based screening method for identifying ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0865502A1 EP0865502A1 (en) | 1998-09-23 |
| EP0865502A4 true EP0865502A4 (en) | 2000-08-16 |
Family
ID=21731102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP96944304A Withdrawn EP0865502A4 (en) | 1995-12-07 | 1996-12-06 | A fluorescence-based screening method for identifying ligands |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0865502A4 (en) |
| JP (1) | JP2000502440A (en) |
| CA (1) | CA2236339A1 (en) |
| DE (1) | DE865502T1 (en) |
| WO (1) | WO1997020952A1 (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2184195C (en) | 1995-10-25 | 2002-04-16 | Andrew Pakula | Screening method for identifying ligands for target proteins |
| KR20000011069A (en) | 1996-05-09 | 2000-02-25 | 스리-디멘셔널 파마슈티컬스 인코포레이티드 | Micro-plate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization |
| CA2270527A1 (en) | 1996-11-04 | 1998-05-14 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for the visualization and interactive processing and analysis of chemical data |
| US6453246B1 (en) | 1996-11-04 | 2002-09-17 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for representing proximity data in a multi-dimensional space |
| US6571227B1 (en) | 1996-11-04 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Method, system and computer program product for non-linear mapping of multi-dimensional data |
| US6261842B1 (en) | 1997-10-23 | 2001-07-17 | Wisconsin Alumni Research Foundation | Microorganism genomics, compositions and methods related thereto |
| HU225767B1 (en) * | 1997-11-12 | 2007-08-28 | Dimensional Pharmaceuticals 3 | High throughput method for functionally classifying proteins identified using a genomics approach |
| US6647358B2 (en) | 1998-09-14 | 2003-11-11 | Lion Bioscience Ag | Pharmacokinetic-based drug design tool and method |
| US6569631B1 (en) | 1998-11-12 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes |
| JP2002535989A (en) | 1999-02-04 | 2002-10-29 | アナディーズ・ファーマスーティカルズ，インコーポレイテッド | Candida albicans SRB-7 |
| US6972198B2 (en) | 1999-02-26 | 2005-12-06 | Cyclacel, Ltd. | Methods and compositions using protein binding partners |
| US6582907B1 (en) * | 1999-12-09 | 2003-06-24 | Pharmacia & Upjohn Company | Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions |
| US6376180B1 (en) * | 1999-12-09 | 2002-04-23 | Pharmacia & Upjohn Company | Methods of identifying compounds that bind to target species under isothermal denaturing conditions |
| US7416524B1 (en) | 2000-02-18 | 2008-08-26 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | System, method and computer program product for fast and efficient searching of large chemical libraries |
| WO2001065462A2 (en) | 2000-02-29 | 2001-09-07 | 3-Dimensional Pharmaceuticals, Inc. | Method and computer program product for designing combinatorial arrays |
| WO2001071624A1 (en) | 2000-03-22 | 2001-09-27 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for representing object relationships in a multidimensional space |
| US7139739B2 (en) | 2000-04-03 | 2006-11-21 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Method, system, and computer program product for representing object relationships in a multidimensional space |
| US7054757B2 (en) | 2001-01-29 | 2006-05-30 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Method, system, and computer program product for analyzing combinatorial libraries |
| WO2002103321A2 (en) * | 2001-06-14 | 2002-12-27 | Anadys Pharmaceuticals, Inc. | Methods of screening for ligands of target molecules |
| EP1637885A1 (en) * | 2004-09-16 | 2006-03-22 | Vivalis | Method of screening by using conformation sensitive peptides |
| GB0421285D0 (en) | 2004-09-24 | 2004-10-27 | Univ Nottingham | Improvements in high content screening |
| US8158340B2 (en) | 2005-12-28 | 2012-04-17 | Corning Incorporated | Methods for detecting conformational changes in bioentities |
| WO2016127100A1 (en) | 2015-02-05 | 2016-08-11 | Promega Corporation | Luciferase-based thermal shift assays |
| GB202118173D0 (en) * | 2021-12-15 | 2022-01-26 | Medicines Discovery Catpult Ltd | Protein stability assay |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4993093A (en) * | 1973-01-08 | 1974-09-04 | ||
| EP0613007A2 (en) * | 1993-02-22 | 1994-08-31 | Eli Lilly And Company | Pharmaceutical screens and antibodies |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200504A (en) * | 1990-10-02 | 1993-04-06 | The Scripps Research Institute | Metallopeptides having stabilized secondary structures |
-
1996
- 1996-12-06 JP JP9521492A patent/JP2000502440A/en active Pending
- 1996-12-06 DE DE0865502T patent/DE865502T1/en active Pending
- 1996-12-06 CA CA002236339A patent/CA2236339A1/en not_active Abandoned
- 1996-12-06 EP EP96944304A patent/EP0865502A4/en not_active Withdrawn
- 1996-12-06 WO PCT/US1996/019698 patent/WO1997020952A1/en not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4993093A (en) * | 1973-01-08 | 1974-09-04 | ||
| EP0613007A2 (en) * | 1993-02-22 | 1994-08-31 | Eli Lilly And Company | Pharmaceutical screens and antibodies |
Non-Patent Citations (2)
| Title |
|---|
| DATABASE WPI Section Ch Week 7526, Derwent World Patents Index; Class B04, AN 75-43214w, XP002024012 * |
| See also references of WO9720952A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0865502A1 (en) | 1998-09-23 |
| CA2236339A1 (en) | 1997-06-12 |
| JP2000502440A (en) | 2000-02-29 |
| DE865502T1 (en) | 1999-08-19 |
| WO1997020952A1 (en) | 1997-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19980530 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| ITCL | It: translation for ep claims filed |
Representative=s name: RICCARDI SERGIO & CO. |
|
| EL | Fr: translation of claims filed | ||
| TCNL | Nl: translation of patent claims filed | ||
| DET | De: translation of patent claims | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20000705 |
|
| AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7G 01N 33/68 A, 7C 12Q 1/68 B, 7G 01N 33/53 B, 7G 01N 33/543 B, 7G 01N 33/58 B |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: ANADYS PHARMACEUTICALS, INC. |
|
| 17Q | First examination report despatched |
Effective date: 20010517 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20011128 |