EP0856067A4 - A binary coding method for use in combinatorial chemistry - Google Patents

A binary coding method for use in combinatorial chemistry

Info

Publication number
EP0856067A4
EP0856067A4 EP96936686A EP96936686A EP0856067A4 EP 0856067 A4 EP0856067 A4 EP 0856067A4 EP 96936686 A EP96936686 A EP 96936686A EP 96936686 A EP96936686 A EP 96936686A EP 0856067 A4 EP0856067 A4 EP 0856067A4
Authority
EP
European Patent Office
Prior art keywords
coding method
combinatorial chemistry
binary coding
binary
combinatorial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96936686A
Other languages
German (de)
French (fr)
Other versions
EP0856067A1 (en
Inventor
Ravi S Garigipati
Susanta K Sarkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0856067A1 publication Critical patent/EP0856067A1/en
Publication of EP0856067A4 publication Critical patent/EP0856067A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96936686A 1995-10-19 1996-10-18 A binary coding method for use in combinatorial chemistry Withdrawn EP0856067A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US562395P 1995-10-19 1995-10-19
US5623P 1995-10-19
PCT/US1996/016718 WO1997014814A1 (en) 1995-10-19 1996-10-18 A binary coding method for use in combinatorial chemistry

Publications (2)

Publication Number Publication Date
EP0856067A1 EP0856067A1 (en) 1998-08-05
EP0856067A4 true EP0856067A4 (en) 2005-09-21

Family

ID=21716840

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96936686A Withdrawn EP0856067A4 (en) 1995-10-19 1996-10-18 A binary coding method for use in combinatorial chemistry

Country Status (3)

Country Link
EP (1) EP0856067A4 (en)
JP (1) JP2000500565A (en)
WO (1) WO1997014814A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010004528A1 (en) * 1995-11-14 2001-06-21 Stephen W. Fesik Use of 13c nuclear magnetic resonance to detect binding to target molecules
HUP9901560A3 (en) 1996-04-08 2000-09-28 Glaxo Group Ltd Mass-based encoding and qualitative analysis of combinatorial libraries
AU767185B2 (en) 1998-03-23 2003-11-06 President And Fellows Of Harvard College Synthesis of compounds and libraries of compounds
IL141759A0 (en) * 1998-09-03 2002-03-10 Trellis Bioinformatics Inc Multihued labels
US6541203B2 (en) 1998-11-23 2003-04-01 President And Fellows Of Harvard College Detecting structural or synthetic information about chemical compounds
US6584411B1 (en) 2000-07-26 2003-06-24 Smithkline Beecham Corporation Methods to facilitate the calculation of yields of reaction products
US6576472B1 (en) 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
DE10117274B4 (en) * 2001-04-06 2005-03-03 Hte Ag The High Throughput Experimentation Company Method for analyzing and archiving at least one material library
EP2498098B1 (en) 2011-03-09 2013-05-22 Bruker BioSpin AG Method for NMR spectroscopy on solid samples
DE102013223891B4 (en) * 2013-11-22 2015-09-17 Joanneum Research Forschungsgesellschaft Mbh Cartridge disposal collectors and method for entry measurement of atmospheric substances

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHABALA J C ET AL: "BINARY ENCODED SMALL-MOLECULE LIBRARIES IN DRUG DISCOVERY AND OPTIMIZATION", PERSPECTIVES IN DRUG DISCOVERY AND DESIGN, ESCOM SCIENCE PUBLISHERS BV, vol. 2, 1994, pages 305 - 318, XP000654519, ISSN: 0928-2866 *
FITCH W L ET AL: "HIGH-RESOLUTION 1H NMR IN SOLID-PHASE ORGANIC SYNTHESIS", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 59, no. 26, 30 December 1994 (1994-12-30), pages 7955 - 7956, XP000974140, ISSN: 0022-3263 *
G.C.LOOK: "Methods for combinatorial organic synthesis: The use of fast 13C NMR analysis for gel phase reaction monitoring", J.ORG.CHEM., vol. 59, no. 25, 1994, pages 7588 - 7590, XP002336433 *
GEYSEN H M ET AL: "ISOTOPE OR MASS ENCODING OF COMBINATORIAL LIBRARIES", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 3, no. 8, August 1996 (1996-08-01), pages 679 - 688, XP002035873, ISSN: 1074-5521 *
K.L. WILLIAMSON ET AL: "Conformational analysis by nuclear magnetic resonance. Nitrogen-15 and carbon-13 spectra of lactams", J.AM.CHEM.SOC., vol. 98, no. 17, 1976, pages 5082 - 5086, XP002336434 *
SARKAR, S.K. ET AL: "An NMR method to identify nondestructively chemical compounds bound to a single solid-phase-synthesis bead for combinatorial chemistry applications", J.AM.CHEM.SOC., vol. 118, no. 9, 6 March 1996 (1996-03-06), pages 2305 - 2306, XP002336089 *
See also references of WO9714814A1 *
SHAPIRO M J ET AL: "NMR METHODS UTILIZED IN COMBINATORIAL CHEMISTRY RESEARCH", PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, PERGAMON PRESS, OXFORD, GB, vol. 35, no. 2, 19 August 1999 (1999-08-19), pages 153 - 200, XP001183038, ISSN: 0079-6565 *

Also Published As

Publication number Publication date
WO1997014814A1 (en) 1997-04-24
JP2000500565A (en) 2000-01-18
EP0856067A1 (en) 1998-08-05

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