EP0845451A4 - Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients - Google Patents

Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients

Info

Publication number
EP0845451A4
EP0845451A4 EP96921146A EP96921146A EP0845451A4 EP 0845451 A4 EP0845451 A4 EP 0845451A4 EP 96921146 A EP96921146 A EP 96921146A EP 96921146 A EP96921146 A EP 96921146A EP 0845451 A4 EP0845451 A4 EP 0845451A4
Authority
EP
European Patent Office
Prior art keywords
alkylene
agent
acid derivatives
drug
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96921146A
Other languages
German (de)
French (fr)
Other versions
EP0845451A1 (en
Inventor
Yuuki Nagao
Kazuhiko Torisu
Nobuyuki Hamanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of EP0845451A1 publication Critical patent/EP0845451A1/en
Publication of EP0845451A4 publication Critical patent/EP0845451A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/16—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same carbon atom of an acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Naphthyloxyacetic acid derivatives represented by general formula (I), wherein A represents H, -(alkylene)COOR1, -(alkylene)CONR2R3, -(alkylene)OH, -(alkylene)tetrazolyl or -(alkylene)-CN; E represents a single bond or alkylene; G represents -S-, -SO-, -SO¿2?-, -O- or -NR?4¿-; L represents alkylene, -(CH¿2?)m-CH=CH-(CH2)n- or -(CH2)x-CH(OH)-(CH2)y-; M represents phenyl, phenyl-(thio, oxy, amino), diphenylmethyl or diphenylmethyl(thio, oxy, amino). The compound (I) binds to PGE2 receptors and exhibit an antagonistic or agonistic effect thereon. Thus, it is useful as a hyperlipemia inhibitor, a medecine for preventing abortion, an analgetic agent, an antidiarrheal, a drug for sleep induction, a diuretic agent, an antidiabetic agent, an interrupting agent, a purgative, an antiulcer agent, a drug for gastritis, a hypotensive drug, etc.
EP96921146A 1995-07-26 1996-07-02 Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients Withdrawn EP0845451A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20927995 1995-07-26
JP209279/95 1995-07-26
PCT/JP1996/001833 WO1997005091A1 (en) 1995-07-26 1996-07-02 Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients

Publications (2)

Publication Number Publication Date
EP0845451A1 EP0845451A1 (en) 1998-06-03
EP0845451A4 true EP0845451A4 (en) 1999-10-13

Family

ID=26437214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96921146A Withdrawn EP0845451A4 (en) 1995-07-26 1996-07-02 Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients

Country Status (4)

Country Link
US (1) US6018068A (en)
EP (1) EP0845451A4 (en)
JP (1) JP3909864B2 (en)
WO (1) WO1997005091A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8750298A (en) * 1997-08-28 1999-03-22 Ono Pharmaceutical Co. Ltd. Peroxisome proliferator-activated receptor controllers
US6335459B1 (en) 1998-12-23 2002-01-01 Syntex (U.S.A.) Llc Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators
EP1177187B1 (en) 1999-04-28 2007-07-25 Sanofi-Aventis Deutschland GmbH Di-aryl acid derivatives as ppar receptor ligands
US6642395B1 (en) * 1999-11-29 2003-11-04 Mitsubishi Rayon Co., Ltd. Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative
GB0031295D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Naphthalene derivatives
JP4529119B2 (en) 2001-08-09 2010-08-25 小野薬品工業株式会社 Carboxylic acid derivative compound and drug containing the compound as an active ingredient
EP1591441A4 (en) * 2003-02-07 2007-10-31 Ono Pharmaceutical Co Carboxylic acid compounds
EP1661580B1 (en) 2003-07-25 2014-01-08 Ono Pharmaceutical Co., Ltd. Remedy for cartilage-related diseases
KR20070091607A (en) * 2004-10-12 2007-09-11 디코드 제네틱스, 아이엔씨. Sulfonamide peri-substituted bicyclics for occlusive artery disease
TWI404529B (en) 2005-06-03 2013-08-11 Ono Pharmaceutical Co Agent for regeneration and/or protection of nerve

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49119718A (en) * 1973-03-23 1974-11-15
US4327022A (en) * 1973-08-16 1982-04-27 Sterling Drug Inc. Heterocyclic alkyl naphthols
EP0061800B1 (en) * 1981-03-24 1985-08-28 FISONS plc Anti srs-a carboxylic acid derivatives, processes for their production and pharmaceutical formulations containing them
JPS57176922A (en) * 1981-03-24 1982-10-30 Fisons Ltd Novel compound
NO174506B (en) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogous procedure for the preparation of therapeutically active compounds
IL79323A (en) * 1985-07-10 1990-03-19 Sanofi Sa Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them
EP0303546B1 (en) * 1987-08-12 1994-12-28 Sanofi O-alkylation process for N-(hydroxy)aralkyl phenyl ethanol amines
US5312961A (en) * 1989-02-14 1994-05-17 Elf Sanofi 2-amino-7-hydroxytetralin carboxylalkyl ethers
FR2643076B1 (en) * 1989-02-14 1991-06-21 Midy Spa CARBOXYALKYL-ETHERS OF 2-AMINO-7-HYDROXYTETRALINE
US5236951A (en) * 1989-06-13 1993-08-17 Sanofi Pharmaceutical compositions for the treatment of ocular disorders
IE65511B1 (en) * 1989-12-29 1995-11-01 Sanofi Sa New phenylethanolaminomethyltetralins
GB9107827D0 (en) * 1991-04-12 1991-05-29 Fujisawa Pharmaceutical Co New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
JPH04334358A (en) * 1991-05-02 1992-11-20 Ono Pharmaceut Co Ltd Condensed benzeneoxy acetic acid derivative
EP0627407A1 (en) * 1993-05-28 1994-12-07 MIDY S.p.A. (7S)-7-(2(3-chlorophenyl)-2-hydroethylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy acetic acid, their pharmaceutically acceptable salts with a beta-3-adrenergic agonist activity and pharmaceutical compositions containing them
DK0657422T3 (en) * 1993-12-09 1998-10-12 Ono Pharmaceutical Co Naphthyloxyacetic acid derivatives such as PEG2 agonists and antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9705091A1 *

Also Published As

Publication number Publication date
US6018068A (en) 2000-01-25
EP0845451A1 (en) 1998-06-03
JP3909864B2 (en) 2007-04-25
WO1997005091A1 (en) 1997-02-13

Similar Documents

Publication Publication Date Title
CA2288122A1 (en) Neuropeptide y receptor antagonist
WO1999042456A3 (en) Novel compounds and their use as positive ampa receptor modulators
IL133623A0 (en) Antithrombotic agents
IL133627A0 (en) Antithrombotic agents
EP0845451A4 (en) Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients
WO2001072728A3 (en) Novel piperazine derivatives
AU2733997A (en) N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3-one derivatives as factor xa inhibitors
WO1996005168A1 (en) Substituted amide derivative
CA2030718A1 (en) Tricyclic Compounds
WO1998035951A3 (en) New aminopiperazine derivatives
WO2001047479A3 (en) Skin moisturizing composition
ATE218345T1 (en) DRUGS FOR SPINOCEREBELLAR DEGENERATION
EP0893437A4 (en) Tryptase inhibitor and novel guanidino derivatives
WO2001021608A3 (en) Novel flavonoids
CA2213609A1 (en) New compounds to modulate hormone receptors, compositions containing them, and their therapeutic use
AU2001272738A1 (en) Composition containing a 15-keto prostaglandin compound for treating of ocular hypertension and glaucoma
EP1295872A4 (en) Drug composition antagonistic to both pgd 2/tx a 22 receptors
EP0603419A4 (en) Novel thiazolidinedione compound and use thereof.
CA2145302A1 (en) Peptide proteinaceous drug nasal powder composition
MY121565A (en) Fluorine-containing compounds and use thereof
NO982229D0 (en) Sulfur-containing di-tert-butylphenol compounds useful as anti-inflammatory agents
EP0926138A4 (en) Diamide compounds and drugs containing the same
EP0754683A4 (en) Ether compound, use thereof, and intermediate for producing the compound
EP1559428A4 (en) Receptor regulator
EP1008345A4 (en) Antiallergic agents

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980213

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19990901

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

17Q First examination report despatched

Effective date: 20021127

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040831