EP0833947A4 - Variant presenilin-2 genes - Google Patents

Variant presenilin-2 genes

Info

Publication number
EP0833947A4
EP0833947A4 EP97916930A EP97916930A EP0833947A4 EP 0833947 A4 EP0833947 A4 EP 0833947A4 EP 97916930 A EP97916930 A EP 97916930A EP 97916930 A EP97916930 A EP 97916930A EP 0833947 A4 EP0833947 A4 EP 0833947A4
Authority
EP
European Patent Office
Prior art keywords
genes
presenilin
variant
variant presenilin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97916930A
Other languages
German (de)
French (fr)
Other versions
EP0833947A1 (en
Inventor
John Hardy
Alison M Goate
Rebecca A Fuldner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
University of South Florida
Institute for Genomic Research
Washington University in St Louis WUSTL
Original Assignee
University of Washington
University of South Florida
Institute for Genomic Research
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, University of South Florida, Institute for Genomic Research, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of EP0833947A1 publication Critical patent/EP0833947A1/en
Publication of EP0833947A4 publication Critical patent/EP0833947A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP97916930A 1996-04-04 1997-03-20 Variant presenilin-2 genes Withdrawn EP0833947A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1486096P 1996-04-04 1996-04-04
US14860 1996-04-04
PCT/US1997/004683 WO1997038133A1 (en) 1996-04-04 1997-03-20 Variant presenilin-2 genes

Publications (2)

Publication Number Publication Date
EP0833947A1 EP0833947A1 (en) 1998-04-08
EP0833947A4 true EP0833947A4 (en) 2003-07-02

Family

ID=21768192

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97916930A Withdrawn EP0833947A4 (en) 1996-04-04 1997-03-20 Variant presenilin-2 genes

Country Status (5)

Country Link
EP (1) EP0833947A4 (en)
JP (1) JP2002515740A (en)
AU (1) AU2541497A (en)
CA (1) CA2222813A1 (en)
WO (1) WO1997038133A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69940906D1 (en) * 1998-05-21 2009-07-02 Mitsubishi Tanabe Pharma Corp METHOD FOR THE INVESTIGATION OF DISEASES OF THE CENTRAL NERVOUS SYSTEM AND METHOD FOR SEARCHING MEDICAMENTS
GB0106051D0 (en) * 2001-03-12 2001-05-02 Isis Innovation Diagnostic screens for alzheimer's disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034099A2 (en) * 1995-04-28 1996-10-31 Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease, and uses therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69229718D1 (en) * 1992-03-20 1999-09-09 Innogenetics Nv Mutated form of the beta amyloid precursor protein gene

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034099A2 (en) * 1995-04-28 1996-10-31 Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease, and uses therefor

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ANWAR R ET AL: "MOLECULAR ANALYSIS OF THE PRESINILIN 1 (S182) GENE IN SPORADIC CASES OF ALZHEIMER'S DISEASE: IDENTIFICATION AND CHARACTERISATION OF UNUSUAL SPLICE VARIANTS", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 66, no. 4, April 1996 (1996-04-01), pages 1774 - 1777, XP000891244, ISSN: 0022-3042 *
CRUTS M ET AL: "THE PRESENILIN GENES: A NEW GENE FAMILY INVOLVED IN ALZHEIMER DISEASE PATHOLOGY", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 5, September 1996 (1996-09-01), pages 1449 - 1455, XP001094396, ISSN: 0964-6906 *
DATABASE GENBANK [online] 8 July 1996 (1996-07-08), XP002236889, retrieved from GENBANK Database accession no. U50871 *
LEVY-LAHAD E ET AL: "A FAMILIAL ALZHEIMER'S DISEASE LOCUS ON CHROMOSOME I", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 269, no. 5226, 18 August 1995 (1995-08-18), pages 970 - 973, XP001093899, ISSN: 0036-8075 *
LEVY-LAHAD E ET AL: "CANDIDATE GENE FOR THE CHROMOSOME 1 FAMILIAL ALZHEIMER'S DISEASE LOCUS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 269, 18 August 1995 (1995-08-18), pages 973 - 977, XP000616667, ISSN: 0036-8075 *
LEVY-LAHAD E ET AL: "GENOMIC STRUCTURE AND EXPRESSION OF STM2, THE CHROMOSOME 1 FAMILIAL ALZHEIMER DISEASE GENE", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 34, no. 2, 1 June 1996 (1996-06-01), pages 198 - 204, XP002072677, ISSN: 0888-7543 *
PEREZ-TUR J ET AL: "A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene", NEUROREPORT, RAPID COMMUNICATIONS OF OXFORD, OXFORD, GB, vol. 7, no. 1, 29 December 1995 (1995-12-29), pages 297 - 301, XP002114867, ISSN: 0959-4965 *
PRIHAR G ET AL: "STRUCTURE AND ALTERNATIVE SPLICING OF THE PRESENILIN-2 GENE", NEUROREPORT, RAPID COMMUNICATIONS OF OXFORD, OXFORD, GB, vol. 7, no. 10, July 1996 (1996-07-01), pages 1680 - 1684, XP002921818, ISSN: 0959-4965 *
ROGAEV E I ET AL: "FAMILIAL ALZHEIMER'S DISEASE IN KINDREDS WITH MISSENSE MUTATIONS INA GENE ON CHROMOSOME 1 RELATED TO THE ALZHEIMER'S DISEASE TYPE 3 GENE", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 376, 31 August 1995 (1995-08-31), pages 775 - 778, XP000196835, ISSN: 0028-0836 *
See also references of WO9738133A1 *

Also Published As

Publication number Publication date
JP2002515740A (en) 2002-05-28
CA2222813A1 (en) 1997-10-16
WO1997038133A1 (en) 1997-10-16
EP0833947A1 (en) 1998-04-08
AU2541497A (en) 1997-10-29

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