EP0830367A4 - High-affinity nucleic acid ligands of cytokines - Google Patents

High-affinity nucleic acid ligands of cytokines

Info

Publication number
EP0830367A4
EP0830367A4 EP96919214A EP96919214A EP0830367A4 EP 0830367 A4 EP0830367 A4 EP 0830367A4 EP 96919214 A EP96919214 A EP 96919214A EP 96919214 A EP96919214 A EP 96919214A EP 0830367 A4 EP0830367 A4 EP 0830367A4
Authority
EP
European Patent Office
Prior art keywords
cytokines
nucleic acid
acid ligands
affinity nucleic
affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96919214A
Other languages
German (de)
French (fr)
Other versions
EP0830367A1 (en
Inventor
Diane Tasset
Nikos Pagratis
Sumedha Jayasena
Larry Gold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/477,527 external-priority patent/US5972599A/en
Priority claimed from US08/481,710 external-priority patent/US6028186A/en
Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc
Priority to EP08010881A priority Critical patent/EP2011503A3/en
Publication of EP0830367A1 publication Critical patent/EP0830367A1/en
Publication of EP0830367A4 publication Critical patent/EP0830367A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96919214A 1995-06-07 1996-06-04 High-affinity nucleic acid ligands of cytokines Withdrawn EP0830367A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08010881A EP2011503A3 (en) 1995-06-07 1996-06-04 High affinity nucleic acid ligands of cytokines

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/477,527 US5972599A (en) 1990-06-11 1995-06-07 High affinity nucleic acid ligands of cytokines
US481710 1995-06-07
US08/481,710 US6028186A (en) 1991-06-10 1995-06-07 High affinity nucleic acid ligands of cytokines
US477527 1995-06-07
PCT/US1996/009537 WO1996040717A1 (en) 1995-06-07 1996-06-04 High-affinity nucleic acid ligands of cytokines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP08010881A Division EP2011503A3 (en) 1995-06-07 1996-06-04 High affinity nucleic acid ligands of cytokines

Publications (2)

Publication Number Publication Date
EP0830367A1 EP0830367A1 (en) 1998-03-25
EP0830367A4 true EP0830367A4 (en) 2003-03-05

Family

ID=27045583

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96919214A Withdrawn EP0830367A4 (en) 1995-06-07 1996-06-04 High-affinity nucleic acid ligands of cytokines

Country Status (4)

Country Link
EP (1) EP0830367A4 (en)
JP (1) JPH11507529A (en)
CA (1) CA2223003A1 (en)
WO (1) WO1996040717A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1041994A4 (en) * 1997-12-31 2003-02-19 Univ Iowa Res Found Use of parasitic biological agents for prevention and control of autoimmune diseases
US6171795B1 (en) * 1999-07-29 2001-01-09 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to CD40ligand
WO2003078623A1 (en) 2002-03-19 2003-09-25 Fujitsu Limited Functional molecule and process for producing the same
US9303262B2 (en) 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators
AU2005220910A1 (en) * 2004-03-05 2005-09-22 Archemix Corp. Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
CN110023499A (en) * 2016-10-24 2019-07-16 拜欧亿思有限公司 Tumor necrosis factor-alpha (TNF-α) combines aptamers and its therapeutical uses
WO2019203904A1 (en) * 2018-04-20 2019-10-24 Academia Sinica Tnf-targeting aptamers and uses thereof for treatment or diagnosing tnf-related inflammatory diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007364A1 (en) * 1993-09-08 1995-03-16 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands and improved methods for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
JPH06508022A (en) * 1991-02-21 1994-09-14 ギリアド　サイエンシズ，インコーポレイテッド Biomolecule-specific aptamers and production methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007364A1 (en) * 1993-09-08 1995-03-16 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands and improved methods for producing the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUDINGER T F ET AL: "New approaches to targeting arthritis with radiopharmaceuticals.", THE JOURNAL OF RHEUMATOLOGY. SUPPLEMENT. CANADA FEB 1995, vol. 43, February 1995 (1995-02-01), pages 62 - 67, XP001098388, ISSN: 0380-0903 *
JELLINEK D ET AL: "INHIBITION OF RECEPTOR BINDING BY HIGH-AFFINITY RNA LIGANDS TO VASCULAR ENDOTHELIAL GROWTH FACTOR", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 33, 30 August 1994 (1994-08-30), pages 10450 - 10456, XP001084739, ISSN: 0006-2960 *
See also references of WO9640717A1 *

Also Published As

Publication number Publication date
WO1996040717A1 (en) 1996-12-19
JPH11507529A (en) 1999-07-06
EP0830367A1 (en) 1998-03-25
CA2223003A1 (en) 1996-12-19

Similar Documents

Publication Publication Date Title
AU4068393A (en) Method of sequencing dna
GB9210273D0 (en) Dna
GB9212164D0 (en) Preparation of nucleic acids
ZA962553B (en) Interferon solution
PL315687A1 (en) Comparative analysis of gene transcript
AU6042396A (en) Amplification of nucleic acid sequences
IL122528A0 (en) Catalytic dna
AP9300538A0 (en) New dna sequences
IL121090A0 (en) Aryl and heteroaryl purine compounds
AU8260491A (en) Dna sequencing
EP0517515A3 (en) Method of purifying dna
GB9502468D0 (en) DNA Sequence
EP0830367A4 (en) High-affinity nucleic acid ligands of cytokines
GB9526218D0 (en) DNA Sequences
AU3004695A (en) Nucleic acid filters
GB9410170D0 (en) Nucleic acid
GB9207598D0 (en) Method of sequencing double stranded dna
IL118493A0 (en) Delta P62 its variants nucleic acid sequences and their uses
GB9210916D0 (en) Nucleic acid quantification
EP0801526A4 (en) Gene transduction system
AU5539096A (en) Nucleic acid sequencing
AU6486796A (en) Intracellular action of nucleic acid ligands
IL112141A0 (en) Nucleic acid ligands
GB9224386D0 (en) Nucleic acid sequence
GB9226165D0 (en) Nucleic acid sequence

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19971202

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 07H 21/02 A, 7C 07H 21/04 B, 7C 12P 19/34 B, 7C 12Q 1/68 B, 7C 12N 15/10 B, 7C 07H 21/00 B

A4 Supplementary search report drawn up and despatched

Effective date: 20030121

17Q First examination report despatched

Effective date: 20030414

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: GILEAD SCIENCES, INC.

17Q First examination report despatched

Effective date: 20030414

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080703