EP0830367A4 - High-affinity nucleic acid ligands of cytokines - Google Patents

High-affinity nucleic acid ligands of cytokines

Info

Publication number
EP0830367A4
EP0830367A4 EP96919214A EP96919214A EP0830367A4 EP 0830367 A4 EP0830367 A4 EP 0830367A4 EP 96919214 A EP96919214 A EP 96919214A EP 96919214 A EP96919214 A EP 96919214A EP 0830367 A4 EP0830367 A4 EP 0830367A4
Authority
EP
European Patent Office
Prior art keywords
cytokines
nucleic acid
acid ligands
affinity nucleic
affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96919214A
Other languages
German (de)
French (fr)
Other versions
EP0830367A1 (en
Inventor
Diane Tasset
Nikos Pagratis
Sumedha Jayasena
Larry Gold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/477,527 external-priority patent/US5972599A/en
Priority claimed from US08/481,710 external-priority patent/US6028186A/en
Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc
Priority to EP08010881A priority Critical patent/EP2011503A3/en
Publication of EP0830367A1 publication Critical patent/EP0830367A1/en
Publication of EP0830367A4 publication Critical patent/EP0830367A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96919214A 1995-06-07 1996-06-04 High-affinity nucleic acid ligands of cytokines Withdrawn EP0830367A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08010881A EP2011503A3 (en) 1995-06-07 1996-06-04 High affinity nucleic acid ligands of cytokines

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/477,527 US5972599A (en) 1990-06-11 1995-06-07 High affinity nucleic acid ligands of cytokines
US08/481,710 US6028186A (en) 1991-06-10 1995-06-07 High affinity nucleic acid ligands of cytokines
US477527 1995-06-07
US481710 1995-06-07
PCT/US1996/009537 WO1996040717A1 (en) 1995-06-07 1996-06-04 High-affinity nucleic acid ligands of cytokines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP08010881A Division EP2011503A3 (en) 1995-06-07 1996-06-04 High affinity nucleic acid ligands of cytokines

Publications (2)

Publication Number Publication Date
EP0830367A1 EP0830367A1 (en) 1998-03-25
EP0830367A4 true EP0830367A4 (en) 2003-03-05

Family

ID=27045583

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96919214A Withdrawn EP0830367A4 (en) 1995-06-07 1996-06-04 High-affinity nucleic acid ligands of cytokines

Country Status (4)

Country Link
EP (1) EP0830367A4 (en)
JP (1) JPH11507529A (en)
CA (1) CA2223003A1 (en)
WO (1) WO1996040717A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1041994A4 (en) * 1997-12-31 2003-02-19 Univ Iowa Res Found Use of parasitic biological agents for prevention and control of autoimmune diseases
US6171795B1 (en) * 1999-07-29 2001-01-09 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to CD40ligand
WO2003078623A1 (en) 2002-03-19 2003-09-25 Fujitsu Limited Functional molecule and process for producing the same
US9303262B2 (en) * 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators
CA2557633A1 (en) * 2004-03-05 2005-09-22 Archemix Corp. Aptamers to the human il-12 cytokine family and their use as autoimmune disease therapeutics
JP2019535249A (en) * 2016-10-24 2019-12-12 バイオイズ カンパニー リミテッド TNF-α binding aptamer and therapeutic use thereof
US11447778B2 (en) * 2018-04-20 2022-09-20 Academia Sinica TNF-targeting aptamers and uses thereof for treatment or diagnosing TNF-related inflammatory diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007364A1 (en) * 1993-09-08 1995-03-16 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands and improved methods for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
CA2104698A1 (en) * 1991-02-21 1992-08-22 John J. Toole Aptamers specific for biomolecules and methods of making

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007364A1 (en) * 1993-09-08 1995-03-16 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands and improved methods for producing the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUDINGER T F ET AL: "New approaches to targeting arthritis with radiopharmaceuticals.", THE JOURNAL OF RHEUMATOLOGY. SUPPLEMENT. CANADA FEB 1995, vol. 43, February 1995 (1995-02-01), pages 62 - 67, XP001098388, ISSN: 0380-0903 *
JELLINEK D ET AL: "INHIBITION OF RECEPTOR BINDING BY HIGH-AFFINITY RNA LIGANDS TO VASCULAR ENDOTHELIAL GROWTH FACTOR", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 33, 30 August 1994 (1994-08-30), pages 10450 - 10456, XP001084739, ISSN: 0006-2960 *
See also references of WO9640717A1 *

Also Published As

Publication number Publication date
JPH11507529A (en) 1999-07-06
CA2223003A1 (en) 1996-12-19
WO1996040717A1 (en) 1996-12-19
EP0830367A1 (en) 1998-03-25

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Legal Events

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