EP0812204A4 - Codominance-mediated toxins - Google Patents

Codominance-mediated toxins

Info

Publication number
EP0812204A4
EP0812204A4 EP96907881A EP96907881A EP0812204A4 EP 0812204 A4 EP0812204 A4 EP 0812204A4 EP 96907881 A EP96907881 A EP 96907881A EP 96907881 A EP96907881 A EP 96907881A EP 0812204 A4 EP0812204 A4 EP 0812204A4
Authority
EP
European Patent Office
Prior art keywords
codominance
toxins
mediated
mediated toxins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96907881A
Other languages
German (de)
French (fr)
Other versions
EP0812204A1 (en
Inventor
Alexander Varshavsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0812204A1 publication Critical patent/EP0812204A1/en
Publication of EP0812204A4 publication Critical patent/EP0812204A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
EP96907881A 1995-03-01 1996-02-28 Codominance-mediated toxins Withdrawn EP0812204A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39743595A 1995-03-01 1995-03-01
US397435 1995-03-01
PCT/US1996/002271 WO1996026733A1 (en) 1995-03-01 1996-02-28 Codominance-mediated toxins

Publications (2)

Publication Number Publication Date
EP0812204A1 EP0812204A1 (en) 1997-12-17
EP0812204A4 true EP0812204A4 (en) 2000-05-03

Family

ID=23571187

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96907881A Withdrawn EP0812204A4 (en) 1995-03-01 1996-02-28 Codominance-mediated toxins

Country Status (4)

Country Link
EP (1) EP0812204A4 (en)
JP (1) JPH11502407A (en)
AU (1) AU5132996A (en)
WO (1) WO1996026733A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050089A2 (en) * 1999-02-26 2000-08-31 Mindset Biopharmaceuticals (Usa) Ltd. Regulation of the stability of recombinant proteins and antiboodies
PL393529A1 (en) * 2010-12-31 2012-07-02 Bioinfobank Spółka Z Ograniczoną Odpowiedzialnością Recombinant cytotoxin and process for the preparation thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009829A2 (en) * 1988-04-07 1989-10-19 Massachusetts Institute Of Technology Methods of generating desired amino-terminal residues in proteins
WO1991018096A1 (en) * 1990-05-17 1991-11-28 Massachusetts Institute Of Technology Methods for trans-destabilization of specific proteins in vivo
WO1994018332A2 (en) * 1993-02-12 1994-08-18 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Anthrax toxin fusion proteins and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009829A2 (en) * 1988-04-07 1989-10-19 Massachusetts Institute Of Technology Methods of generating desired amino-terminal residues in proteins
WO1991018096A1 (en) * 1990-05-17 1991-11-28 Massachusetts Institute Of Technology Methods for trans-destabilization of specific proteins in vivo
WO1994018332A2 (en) * 1993-02-12 1994-08-18 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Anthrax toxin fusion proteins and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COOK J P ET AL: "BIOLOGICALLY ACTIVE INTERLEUKIN 2-RICIN A CHAIN FUSION PROTEINS MAYREQUIRE INTRACELLULAR PROTEOLYTIC CLEAVAGE TO EXHIBIT A CYTOTOXIC EFFECT", BIOCONJUGATE CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, vol. 4, no. 6, 1 November 1993 (1993-11-01), pages 440 - 447, XP000417282, ISSN: 1043-1802 *
JOHNSON E S ET AL: "Ubiquitin as a degradation signal.", EMBO JOURNAL, (1992 FEB) 11 (2) 497-505., XP002130422 *
See also references of WO9626733A1 *
VITETTA E S ET AL: "Immunotoxins: magic bullets or misguided missiles ?.", IMMUNOLOGY TODAY, (1993 JUN) 14 (6) 252-9. REF: 51, XP002130421 *

Also Published As

Publication number Publication date
EP0812204A1 (en) 1997-12-17
WO1996026733A1 (en) 1996-09-06
AU5132996A (en) 1996-09-18
JPH11502407A (en) 1999-03-02

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