EP0810882A4 - Methodes et compositions de regulation de l'expression de cd28 - Google Patents
Methodes et compositions de regulation de l'expression de cd28Info
- Publication number
- EP0810882A4 EP0810882A4 EP96909477A EP96909477A EP0810882A4 EP 0810882 A4 EP0810882 A4 EP 0810882A4 EP 96909477 A EP96909477 A EP 96909477A EP 96909477 A EP96909477 A EP 96909477A EP 0810882 A4 EP0810882 A4 EP 0810882A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- regulation
- expression
- compositions
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38704195A | 1995-02-09 | 1995-02-09 | |
US387041 | 1995-02-09 | ||
PCT/US1996/001507 WO1996024380A1 (fr) | 1995-02-09 | 1996-02-05 | Methodes et compositions de regulation de l'expression de cd28 |
1997-05-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0810882A1 EP0810882A1 (fr) | 1997-12-10 |
EP0810882A4 true EP0810882A4 (fr) | 1999-05-19 |
Family
ID=23528194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96909477A Withdrawn EP0810882A4 (fr) | 1995-02-09 | 1996-02-05 | Methodes et compositions de regulation de l'expression de cd28 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0810882A4 (fr) |
HU (1) | HUP9801629A3 (fr) |
PL (1) | PL321711A1 (fr) |
WO (1) | WO1996024380A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
IT1277025B1 (it) * | 1995-12-04 | 1997-11-04 | Cooperativa Centro Ricerche Po | Classe di oligonucleotidi fosfodiesterici ad attivita' citotossica composizioni farmaceutiche che li contengono e loro uso |
PL334197A1 (en) * | 1996-12-27 | 2000-02-14 | Icn Pharmaceuticals | Oligonucleotidic aptamers of high g content and methods of modulating immunilogical response |
AU777225B2 (en) * | 1998-09-03 | 2004-10-07 | Coley Pharmaceutical Gmbh | G-motif oligonucleotides and uses thereof |
EP1366077B1 (fr) | 2000-09-15 | 2011-05-25 | Coley Pharmaceutical GmbH | Procede de criblage a haut rendement d'immuno-agoniste/antagoniste base sur cpg |
WO2011011700A2 (fr) * | 2009-07-24 | 2011-01-27 | Curna, Inc. | Traitement des maladies associées à une sirtuine (sirt) par inhibition du produit de transcription anti-sens naturel chez une sirtuine (sirt) |
WO2011038210A2 (fr) | 2009-09-25 | 2011-03-31 | Curna, Inc. | Traitement de maladies associées à la filaggrine (flg) par modulation de l'expression et de l'activité de flg |
WO2014090985A1 (fr) * | 2012-12-13 | 2014-06-19 | Universität Leipzig | Modulation des lymphocytes t par saut d'exon |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0575537A1 (fr) * | 1991-03-08 | 1993-12-29 | Cytomed, Inc. | Proteines cd28 solubles et procedes de traitement au moyen desdites proteines |
US6664107B1 (en) * | 1993-05-26 | 2003-12-16 | Ontario Cancer Institute, University Health Network | CD45 disrupted nucleic acid |
-
1996
- 1996-02-05 HU HU9801629A patent/HUP9801629A3/hu unknown
- 1996-02-05 PL PL96321711A patent/PL321711A1/xx unknown
- 1996-02-05 EP EP96909477A patent/EP0810882A4/fr not_active Withdrawn
- 1996-02-05 WO PCT/US1996/001507 patent/WO1996024380A1/fr not_active Application Discontinuation
Non-Patent Citations (4)
Title |
---|
MACAYA R F ET AL: "THROMBIN-BINDING DNA APTAMER FORMS A UNIMOLECULAR QUADRUPLEX STRUCTURE IN SOLUTION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 90, April 1993 (1993-04-01), pages 3745 - 3749, XP002043117 * |
See also references of WO9624380A1 * |
TAM R C ET AL: "BIOLOGICAL AVAILABILITY AND NUCLEASE RESISTANCE EXTEND THE IN-VITRO ACTIVITY OF A PHOSPHOROTHIOATE-3'HYDROXYPROPYLAMINE OLIGONUCLEOTIDE", NUCLEIC ACIDS RESEARCH, (25 MAR 1994) VOL. 22, NO. 6, PP. 977-986., XP002096884 * |
TAM R C ET AL: "Oligonucleotide-mediated inhibition of CD28 expression induces human T cell hyporesponsiveness and manifests impaired contact hypersensitivity in mice.", JOURNAL OF IMMUNOLOGY, (1997 JAN 1) 158 (1) 200-8., XP002096885 * |
Also Published As
Publication number | Publication date |
---|---|
PL321711A1 (en) | 1997-12-22 |
EP0810882A1 (fr) | 1997-12-10 |
HUP9801629A2 (hu) | 1998-10-28 |
HUP9801629A3 (en) | 2000-10-30 |
WO1996024380A1 (fr) | 1996-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19970908 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: SI PAYMENT 970908 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19990401 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 20000809 |