EP0804201A4 - Method of treating opportunistic infections with azaspiranes - Google Patents

Method of treating opportunistic infections with azaspiranes

Info

Publication number
EP0804201A4
EP0804201A4 EP95928072A EP95928072A EP0804201A4 EP 0804201 A4 EP0804201 A4 EP 0804201A4 EP 95928072 A EP95928072 A EP 95928072A EP 95928072 A EP95928072 A EP 95928072A EP 0804201 A4 EP0804201 A4 EP 0804201A4
Authority
EP
European Patent Office
Prior art keywords
azaspiranes
opportunistic infections
treating opportunistic
treating
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95928072A
Other languages
German (de)
French (fr)
Other versions
EP0804201A1 (en
Inventor
Alison Mary Badger
Peter John Bugelski
Danuta J Herzyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0804201A1 publication Critical patent/EP0804201A1/en
Publication of EP0804201A4 publication Critical patent/EP0804201A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP95928072A 1994-07-23 1995-07-14 Method of treating opportunistic infections with azaspiranes Withdrawn EP0804201A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9414902A GB9414902D0 (en) 1994-07-23 1994-07-23 Methods
GB9414902 1994-07-23
PCT/US1995/008915 WO1996003126A1 (en) 1994-07-23 1995-07-14 Method of treating opportunistic infections with azaspiranes

Publications (2)

Publication Number Publication Date
EP0804201A1 EP0804201A1 (en) 1997-11-05
EP0804201A4 true EP0804201A4 (en) 2000-04-26

Family

ID=10758802

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95928072A Withdrawn EP0804201A4 (en) 1994-07-23 1995-07-14 Method of treating opportunistic infections with azaspiranes

Country Status (15)

Country Link
EP (1) EP0804201A4 (en)
JP (1) JPH10503202A (en)
KR (1) KR970704446A (en)
CN (1) CN1157564A (en)
AU (1) AU684384B2 (en)
BR (1) BR9508332A (en)
CA (1) CA2195778A1 (en)
CZ (1) CZ286482B6 (en)
GB (1) GB9414902D0 (en)
HU (1) HUT77379A (en)
MX (1) MX9700626A (en)
NO (1) NO310096B1 (en)
NZ (1) NZ290974A (en)
WO (1) WO1996003126A1 (en)
ZA (1) ZA956098B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9601909A (en) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N, n-diethyl-8,8-dipropyl-2-azaspiro (4,5) decane-2-propan amine dimaleate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014462A1 (en) * 1991-02-19 1992-09-03 Smithkline Beecham Corporation Cytokine inhibitors
WO1992022294A1 (en) * 1991-06-07 1992-12-23 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014462A1 (en) * 1991-02-19 1992-09-03 Smithkline Beecham Corporation Cytokine inhibitors
WO1992022294A1 (en) * 1991-06-07 1992-12-23 Smithkline Beecham Corporation Immunomodulatory azaspiranes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BADGER A M ET AL.: "Effects of SK&F 105685, a novel anti-arthritic agent, on immune function in the dog", INT. J. IMMUNOPHARMACOL., vol. 15, no. 2, 1993, pages 113 - 123, XP002106846 *
BADGER A M ET AL: "BENEFICIAL EFFECTS OF SK&F 105685 IN RAT ADJUVANT ARTHRITIS: PROPHYLACTIC AND THERAPEUTIC EFFECTS ON DISEASE PARAMETER PROGRESSION", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 15, no. 3, 1 January 1993 (1993-01-01), pages 343 - 347, 349 - 35, XP000677832 *
BADGER A M ET AL: "THERAPEUTIC ACTIVITY OF SK&F 105685, A NOVEL AZASPIRANE WITH SUPPRESSOR-CELL INDUCING ACTIVITY", CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol. 11, no. SUPPL. 08, 1 March 1993 (1993-03-01), pages S107 - S109, XP000677527 *
See also references of WO9603126A1 *

Also Published As

Publication number Publication date
WO1996003126A1 (en) 1996-02-08
BR9508332A (en) 1997-11-04
CA2195778A1 (en) 1996-02-08
NO970284D0 (en) 1997-01-22
AU3190995A (en) 1996-02-22
JPH10503202A (en) 1998-03-24
CN1157564A (en) 1997-08-20
NZ290974A (en) 1999-08-30
CZ286482B6 (en) 2000-04-12
HU9700201D0 (en) 1997-04-28
MX9700626A (en) 1997-05-31
GB9414902D0 (en) 1994-09-14
ZA956098B (en) 1996-05-23
CZ20997A3 (en) 1997-10-15
KR970704446A (en) 1997-09-06
EP0804201A1 (en) 1997-11-05
AU684384B2 (en) 1997-12-11
NO970284L (en) 1997-03-19
NO310096B1 (en) 2001-05-21
HUT77379A (en) 1998-04-28

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