EP0804076A4 - Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents - Google Patents
Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agentsInfo
- Publication number
- EP0804076A4 EP0804076A4 EP95938753A EP95938753A EP0804076A4 EP 0804076 A4 EP0804076 A4 EP 0804076A4 EP 95938753 A EP95938753 A EP 95938753A EP 95938753 A EP95938753 A EP 95938753A EP 0804076 A4 EP0804076 A4 EP 0804076A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- adenoviruses
- gene therapy
- immunosuppressive agents
- repeated administration
- therapy involving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Transplantation (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32567994A | 1994-10-19 | 1994-10-19 | |
US325679 | 1994-10-19 | ||
US47848295A | 1995-06-07 | 1995-06-07 | |
US478482 | 1995-06-07 | ||
PCT/US1995/013253 WO1996012406A1 (en) | 1994-10-19 | 1995-10-19 | Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0804076A1 EP0804076A1 (en) | 1997-11-05 |
EP0804076A4 true EP0804076A4 (en) | 1998-10-21 |
Family
ID=26985040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95938753A Withdrawn EP0804076A4 (en) | 1994-10-19 | 1995-10-19 | Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0804076A4 (en) |
JP (1) | JPH10507758A (en) |
CA (1) | CA2200869A1 (en) |
WO (1) | WO1996012406A1 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5872154A (en) * | 1995-02-24 | 1999-02-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant adenovirus |
US6251957B1 (en) | 1995-02-24 | 2001-06-26 | Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
US6372208B1 (en) | 1999-09-28 | 2002-04-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
DK0811073T3 (en) * | 1995-02-24 | 2007-05-21 | Univ Pennsylvania | Use of immune modulators to produce drugs to inhibit immune responses to co-administered recombinants |
WO1997030167A1 (en) * | 1996-02-13 | 1997-08-21 | The Trustees Of The University Of Pennsylvania | Method of treating liver disorders |
US6211160B1 (en) | 1996-09-06 | 2001-04-03 | The Trustees Of The University Of Pennsylvania | Method for tolerizing a mammalian patient to administration of gene therapy virus vectors |
PL334902A1 (en) | 1997-01-29 | 2000-03-27 | Cornell Res Foundation Inc | Repeatable local delivery of adenoviral vector in order to induce angiogenesis |
US5985824A (en) * | 1997-02-27 | 1999-11-16 | Genzyme Corporation | Methods and compositions for treating cystic fibrosis |
DE19711803A1 (en) * | 1997-03-21 | 1998-09-24 | Hoechst Ag | Extension of expression of transgenic proteins by immunomodulating treatment with 15-deoxyspergualin |
CA2343916A1 (en) * | 1998-09-21 | 2000-03-30 | Genetics Institute, Inc. | Methods of downmodulating the immune response to therapeutic proteins |
WO2000029033A2 (en) * | 1998-11-17 | 2000-05-25 | The General Hospital Corporation | A method of genetic vector delivery |
IL150485A0 (en) * | 1999-12-28 | 2002-12-01 | Novartis Ag | Method of achieving persistent transgene expression |
US20020014242A1 (en) | 2000-07-31 | 2002-02-07 | Abraham Scaria | Use of rapamycin to inhibit immune response and induce tolerance to gene therapy vector and encoded transgene products |
EP1435776A4 (en) | 2001-09-24 | 2006-01-25 | Univ Pittsburgh | Anticancer vaccine and diganostic methods and reagents |
BR0214350A (en) | 2001-11-21 | 2005-05-10 | Univ Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same and methods of use |
EP1944043A1 (en) | 2001-11-21 | 2008-07-16 | The Trustees of the University of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
US20060147420A1 (en) | 2004-03-10 | 2006-07-06 | Juan Fueyo | Oncolytic adenovirus armed with therapeutic genes |
CN1893981B (en) * | 2003-12-10 | 2011-03-23 | 坎基股份有限公司 | Methods and compositions for treatment of interferon-resistant tumors |
PT1809321E (en) | 2004-10-08 | 2012-05-17 | Us Gov Health & Human Serv | Adoptive immunotherapy with enhanced t lymphocyte survival |
WO2007044033A2 (en) | 2004-12-07 | 2007-04-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Therapeutic and diagnostic cloned mhc-unrestricted receptor specific for the muc1 tumor associated antigen |
EP2220217A2 (en) | 2007-11-28 | 2010-08-25 | The Trustees of the University of Pennsylvania | Simian subfamily c adenoviruses sadv-40, -31, and-34 and uses thereof |
ES2607029T3 (en) | 2007-11-28 | 2017-03-28 | The Trustees Of The University Of Pennsylvania | Adenovirus comprising a hexon protein of the apex adenovirus E of simian SAdV-39 and uses thereof |
US8470310B2 (en) | 2008-03-04 | 2013-06-25 | The Trustees Of The University Of Pennsylvania | Simian adenoviruses SAdV-36, -42.1, -42.2, and -44 and uses thereof |
US8748170B2 (en) | 2008-07-25 | 2014-06-10 | University of Pittsburgh—of the Commonwealth System of Higher Education | Polypeptides derived from cyclin B1 and uses thereof |
EP2774985B1 (en) | 2008-10-31 | 2016-12-14 | The Trustees Of The University Of Pennsylvania | Simian adenovirus SAdV-43 and uses thereof |
EP2435559A1 (en) | 2009-05-29 | 2012-04-04 | The Trustees Of The University Of Pennsylvania | Simian adenovirus 41 and uses thereof |
WO2012071318A2 (en) | 2010-11-23 | 2012-05-31 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenoviruses a1321, a1325, a1295, a1309, a1316 and a1322 and uses thereof |
CA2834532A1 (en) | 2011-04-29 | 2012-11-01 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers to reduce cytotoxic t lymphocyte responses |
WO2013173702A2 (en) | 2012-05-18 | 2013-11-21 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof |
KR20220025908A (en) | 2013-05-03 | 2022-03-03 | 셀렉타 바이오사이언시즈, 인크. | Local, concomitant administration of tolerogenic synthetic nanocarriers to reduce type i and type iv hypersensitivity |
CA2915973A1 (en) | 2013-06-18 | 2014-12-24 | Dnatrix, Inc. | Treatment of brain cancer with oncolytic adenovirus |
EP3189147A1 (en) * | 2014-09-07 | 2017-07-12 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene expression modulating anti-viral transfer vector immune responses |
US20200325483A1 (en) * | 2016-05-12 | 2020-10-15 | Brian P. Hanley | Safe delivery of crispr and other gene therapies to large fractions of somatic cells in humans and animals |
BR112019013862A2 (en) * | 2017-01-07 | 2020-04-14 | Selecta Biosciences Inc | standard dosage of immunosuppressants coupled to synthetic nanocarriers |
CA3055936A1 (en) | 2017-03-11 | 2018-09-20 | Selecta Biosciences, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
EP3488851A1 (en) * | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
WO2020223205A1 (en) * | 2019-04-28 | 2020-11-05 | Selecta Biosciences, Inc. | Methods for treatment of subjects with preexisting immunity to viral transfer vectors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE221379T1 (en) * | 1991-05-01 | 2002-08-15 | Jackson H M Found Military Med | METHOD FOR TREATING INFECTIOUS RESPIRATORY DISEASES |
-
1995
- 1995-10-19 WO PCT/US1995/013253 patent/WO1996012406A1/en not_active Application Discontinuation
- 1995-10-19 CA CA002200869A patent/CA2200869A1/en not_active Abandoned
- 1995-10-19 JP JP8514013A patent/JPH10507758A/en active Pending
- 1995-10-19 EP EP95938753A patent/EP0804076A4/en not_active Withdrawn
Non-Patent Citations (2)
Title |
---|
No further relevant documents disclosed * |
See also references of WO9612406A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPH10507758A (en) | 1998-07-28 |
CA2200869A1 (en) | 1996-05-02 |
WO1996012406A1 (en) | 1996-05-02 |
EP0804076A1 (en) | 1997-11-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19970417 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19980904 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20020501 |