EP0783513A4 - Novel estrenes for inducing hypothalamic effects - Google Patents

Novel estrenes for inducing hypothalamic effects

Info

Publication number
EP0783513A4
EP0783513A4 EP95935237A EP95935237A EP0783513A4 EP 0783513 A4 EP0783513 A4 EP 0783513A4 EP 95935237 A EP95935237 A EP 95935237A EP 95935237 A EP95935237 A EP 95935237A EP 0783513 A4 EP0783513 A4 EP 0783513A4
Authority
EP
European Patent Office
Prior art keywords
estrenes
novel
hypothalamic effects
inducing
inducing hypothalamic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95935237A
Other languages
German (de)
French (fr)
Other versions
EP0783513A1 (en
Inventor
David L Berliner
Nathan W Adams
Clive L Jennings-White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pherin Corp
Original Assignee
Pherin Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pherin Corp filed Critical Pherin Corp
Priority to EP98203950A priority Critical patent/EP0924219A3/en
Publication of EP0783513A1 publication Critical patent/EP0783513A1/en
Publication of EP0783513A4 publication Critical patent/EP0783513A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0007—Androstane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0055—Estrane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/002—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 13 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C07J75/005—Preparation of steroids by cyclization of non-steroid compounds
EP95935237A 1994-09-29 1995-09-29 Novel estrenes for inducing hypothalamic effects Withdrawn EP0783513A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP98203950A EP0924219A3 (en) 1994-09-29 1995-09-29 Novel estrenes for inducing hypothalamic effects

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31605094A 1994-09-29 1994-09-29
PCT/US1995/012542 WO1996010032A1 (en) 1994-09-29 1995-09-29 Novel estrenes for inducing hypothalamic effects
US316050 1996-11-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP98203950A Division EP0924219A3 (en) 1994-09-29 1995-09-29 Novel estrenes for inducing hypothalamic effects

Publications (2)

Publication Number Publication Date
EP0783513A1 EP0783513A1 (en) 1997-07-16
EP0783513A4 true EP0783513A4 (en) 2000-03-08

Family

ID=23227259

Family Applications (2)

Application Number Title Priority Date Filing Date
EP98203950A Withdrawn EP0924219A3 (en) 1994-09-29 1995-09-29 Novel estrenes for inducing hypothalamic effects
EP95935237A Withdrawn EP0783513A4 (en) 1994-09-29 1995-09-29 Novel estrenes for inducing hypothalamic effects

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP98203950A Withdrawn EP0924219A3 (en) 1994-09-29 1995-09-29 Novel estrenes for inducing hypothalamic effects

Country Status (16)

Country Link
EP (2) EP0924219A3 (en)
JP (1) JPH10509423A (en)
KR (1) KR970706297A (en)
CN (1) CN1167489A (en)
AU (1) AU705422B2 (en)
BR (1) BR9509098A (en)
CA (1) CA2199044A1 (en)
CZ (1) CZ92697A3 (en)
FI (1) FI971315A0 (en)
HU (1) HUT76856A (en)
MX (1) MX9702253A (en)
NO (1) NO971417L (en)
NZ (1) NZ294510A (en)
PL (1) PL319601A1 (en)
RU (1) RU2160279C2 (en)
WO (1) WO1996010032A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5969168A (en) * 1991-01-07 1999-10-19 Pherin Corporation Androstanes for inducing hypothalamic effects
US6331534B1 (en) 1994-08-04 2001-12-18 Pherin Pharmaceuticals, Inc. Steroids as neurochemical stimulators of the VNO to alleviate pain
US6066627A (en) * 1994-08-04 2000-05-23 Pherin Corporation Steroids as neurochemical initiators of change in human blood levels of LH
US6117860A (en) * 1994-08-04 2000-09-12 Pherin Pharmaceuticals, Inc. Steroids as neurochemical stimulators of the VNO to treat paroxistic tachycardia
US6057439A (en) * 1994-08-04 2000-05-02 Pherin Corporation Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety
US5922699A (en) * 1996-06-07 1999-07-13 Pherin Corporation 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function
CA2260253A1 (en) * 1996-07-23 1998-01-29 Clive L. Jennings-White Steroids as neurochemical stimulators of the vno to alleviate symptoms of pms and anxiety
DE102007022916A1 (en) * 2007-05-14 2008-11-20 Henkel Ag & Co. Kgaa Pheromone-containing cosmetic products
CN111532108A (en) * 2020-05-12 2020-08-14 中国科学院心理研究所 New application of estratetraene

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2984677A (en) * 1957-12-03 1961-05-16 Lasdon Foundation Inc Ethers of 1, 3, 5, 16-estratetraen-3-ol
US4117234A (en) * 1972-08-17 1978-09-26 The Board Of Trustees Of The Leland Stanford Junior University Intermediate in the synthesis of estrone
DE3741801A1 (en) * 1987-12-07 1989-06-15 Schering Ag 17-Methylene-estratrienes
EP0562843A2 (en) * 1992-03-24 1993-09-29 Erox Corporation Fragrance compositions and other compositions which contain human pheromones
WO1994028903A1 (en) * 1993-06-15 1994-12-22 Pherin Corporation Estrene steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3264327A (en) * 1962-07-27 1966-08-02 Syntex Corp 17alpha-fluoro-, 17beta-chlorofluoroacetoxy- and 17beta-methyl-delta4-and delta5-androstene derivatives
US5969168A (en) * 1991-01-07 1999-10-19 Pherin Corporation Androstanes for inducing hypothalamic effects

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2984677A (en) * 1957-12-03 1961-05-16 Lasdon Foundation Inc Ethers of 1, 3, 5, 16-estratetraen-3-ol
US4117234A (en) * 1972-08-17 1978-09-26 The Board Of Trustees Of The Leland Stanford Junior University Intermediate in the synthesis of estrone
DE3741801A1 (en) * 1987-12-07 1989-06-15 Schering Ag 17-Methylene-estratrienes
EP0562843A2 (en) * 1992-03-24 1993-09-29 Erox Corporation Fragrance compositions and other compositions which contain human pheromones
WO1994028903A1 (en) * 1993-06-15 1994-12-22 Pherin Corporation Estrene steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods

Non-Patent Citations (24)

* Cited by examiner, † Cited by third party
Title
A. CALVET ET AL: "Vitesses de Reduction de Ceto-3- Steroides par le Tri-tert-butoxy-Hydruro Aminate de Sodium", TETRAHEDRON LETTERS., no. 21, May 1972 (1972-05-01), ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 2157 - 2160, XP002121393, ISSN: 0040-4039 *
A. M. PONOMAREV ET AL, JOURNAL OF ORGANIC CHEMISTRY OF THE USSR. (ZHURNAL ORGANICHESKOI KHIMII), vol. 7, 1971, CONSULTANTS BUREAU. NEW YORK., US, pages 1477 - 1479, XP002121397 *
A. N. CHERKASOV ET AL, JOURNAL OF ORGANIC CHEMISTRY OF THE USSR. (ZHURNAL ORGANICHESKOI KHIMII), vol. 7, 1971, CONSULTANTS BUREAU. NEW YORK., US, pages 955 - 961, XP002121398 *
ARUNACHALAM T ET AL: "Iodoestrogens, syntheses, and interaction with uterine receptors", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 254, no. 13, 10 July 1979 (1979-07-10), pages 5900 - 5905, XP002089838, ISSN: 0021-9258 *
BASCOUL, JACQUES ET AL: "Directing effect of skeletal rearrangements", TETRAHEDRON LETT. (1969), (28), 2401-5, XP002121383 *
BASCOUL, JACQUES ET AL: "Partial synthesis of natural steroid enantiomers. V. Rearrangement of ditertiary epoxides of A-nor and A,19-bisnorsteroids. Example of backbone rearrangement", BULL. SOC. CHIM. FR. (1969), (1), 189-94, XP002121384 *
BOOTH, W. D. ET AL: "The isolation, purification and some properties of pheromaxein, the pheromonal steroid-binding protein, in porcine submaxillary glands and saliva", J. ENDOCRINOL. (1988), 118(1), 47-57, 2 PLATES, XP002121381 *
G. OHLOFF ET AL: "Structural and Configurational Dependence of the Sensory Process in Steroids", HELVETICA CHIMICA ACTA., vol. 66, no. 1, 1983, BASEL CH, pages 192 - 217, XP002069805 *
H. DANNENBERG ET AL: "Über die durch Friedel-Krafts-Acetylierung von delta-1,3,5(10)-Östratrien-Verbindungen zugänglichen Amine", CHEMISCHE BERICHTE, vol. 97, no. 1, 1964, WEINHEIM DE, pages 140 - 150, XP002121389 *
H. TAKAGI ET AL: "Synthesis and mechanism of hydrolysis of estrogen 6-sulfates: model compounds for demonstrating the carinogenesis of estrogen", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION., vol. 56, no. 4, 1991, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY., US, pages 173 - 179, XP002121386, ISSN: 0039-128X *
HAINAUT D ET AL: "Conformational transmission and stability of double bonds. I. Preparation of model derivatives in the.DELTA.8 and.DELTA.9(11) estrene series", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE. 2 PARTIE - CHIMIE ORGANIQUE, BIOCHIMIE., no. 3-4, 1978, PARIS FR, pages 119 - 125, XP002069804 *
J. P. DUSZA ET AL: "STEROID CONJUGATES IV. THE PREPARATION OF STEROID SULFATES WITH TRIETHYLAMINE-SULFUR TRIOXIDE", STEROIDS., vol. 12, no. 1, July 1968 (1968-07-01), ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY., US, pages 49 - 61, XP002121390 *
J. R. BULL ET AL: "Hydroxylation of delta-4 Steroids by Osmium Tetroxide; Stereochemistry and Substituent Effects", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1., no. 7, 1977, CHEMICAL SOCIETY. LETCHWORTH., GB, pages 724 - 730, XP002121394, ISSN: 0300-922X *
L. RUZICKA ET AL: "Über Steroide und Sexualhormone. Untersuchungen über den Zusammenhang zwischen Konstitution und Geruch bei Steroiden. Methyl-androstan- und Allopregnan-Derivate", HELVETICA CHIMICA ACTA., vol. 30, no. 3, 1947, BASEL CH, pages 867 - 878, XP002069806 *
M. A. KRAEVSKAYA ET AL: "Molecular Mechansims of Olefaction: Binding of Boar Sex Pheremone 5.alpha.-Androst-16-en-3-one and Its Analogs by Cytosolic Fraction of Porcine Olefactory Epithelium", SENSORNYE SISTEMY (ENGLISH TRANSLATION - PLENUM PUBLISHING CORP), vol. 1, no. 2, 1987, pages 99 - 107, XP002124893 *
M. MOUSSERON-CANET ET AL: "Orientation stérique de l'époxidation en série stérolique. II - Conformation et réactivité de nor-19 stéroïdes et de des-D dinor-18,19-stéroïdes", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE., no. 12, 1966, SOCIETE FRANCAISE DE CHIMIE. PARIS., FR, pages 3858 - 3867, XP002121392, ISSN: 0037-8968 *
M. PONS ET AL: "Structural requirements for maximal inhibitory allosteric effect of estrogens and estrogen analogs on glutamate dehydrogenase", EUR. J. BIOCHEM., vol. 84, no. 1, 1978, pages 257 - 266, XP002121388 *
O. N. MINAILOVA ET AL: "Silylsteroids VIII. Synthesis of 1.alpha.-(trimethylsilyl)-19-nortestosterone and its Analogs by the Reductive Silylation of Estradiol Ethers", JOURNAL OF GENERAL CHEMISTRY USSR., vol. 53, no. 3, March 1983 (1983-03-01), CONSULTANTS BUREAU. NEW YORK., US, pages 539 - 550, XP002121391 *
ROMER J ET AL: "ANDROSTA-4,16-DIENE-3,6-DIONE: AN UNKNOWN MEMBER AMONG THE SMELLING ANDROST-16-ENES", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, vol. 51, no. 5/06, 1 May 1988 (1988-05-01), pages 577 - 581, XP000027980, ISSN: 0039-128X *
See also references of WO9610032A1 *
SIGNORET, J. P. ET AL: "Utilization of various synthetic odorous products to facilitate detection of heats in the sow", ANN. ZOOTECH. (1975), 24(4), 639-43, XP002121379 *
U. KLEIN ET AL: "Notiz zur Thermolyse von (17S)-3-Methoxyspiro-[1,3,5(10)-estratrien-17,2'-oxiran]", CHEMISCHE BERICHTE., vol. 110, no. 6, June 1977 (1977-06-01), VERLAG CHEMIE GMBH. WEINHEIM., DE, pages 2401 - 2403, XP002121385, ISSN: 0009-2940 *
V. PRELOG ET AL: "29. Steroide und Sexualhormone. Über ein neues Stereoisomeres des Oestriols", HELVETICA CHIMICA ACTA, vol. 28, no. 1, 1945, BASEL CH, pages 250 - 256, XP002121380 *
W. JOHNS: "Synthesis of 3-Methoxy-17-acetyl-18-nor-estra-1,3,5(10),16-tetraene", JOURNAL OF ORGANIC CHEMISTRY., vol. 28, no. 7, July 1963 (1963-07-01), AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 1856 - 1861, XP002121382, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
RU2160279C2 (en) 2000-12-10
CZ92697A3 (en) 1997-09-17
HUT76856A (en) 1997-12-29
KR970706297A (en) 1997-11-03
BR9509098A (en) 1998-07-14
EP0783513A1 (en) 1997-07-16
EP0924219A2 (en) 1999-06-23
EP0924219A3 (en) 2002-01-23
PL319601A1 (en) 1997-08-18
NZ294510A (en) 1999-04-29
CN1167489A (en) 1997-12-10
AU705422B2 (en) 1999-05-20
JPH10509423A (en) 1998-09-14
NO971417L (en) 1997-05-23
MX9702253A (en) 1997-06-28
CA2199044A1 (en) 1996-04-04
AU3733195A (en) 1996-04-19
WO1996010032A1 (en) 1996-04-04
NO971417D0 (en) 1997-03-25
FI971315A (en) 1997-03-27
FI971315A0 (en) 1997-03-27

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