EP0754039A4 - Methods of using iron chelating compounds to reduce free radical damage in mammals - Google Patents

Methods of using iron chelating compounds to reduce free radical damage in mammals

Info

Publication number
EP0754039A4
EP0754039A4 EP95912791A EP95912791A EP0754039A4 EP 0754039 A4 EP0754039 A4 EP 0754039A4 EP 95912791 A EP95912791 A EP 95912791A EP 95912791 A EP95912791 A EP 95912791A EP 0754039 A4 EP0754039 A4 EP 0754039A4
Authority
EP
European Patent Office
Prior art keywords
mammals
methods
free radical
chelating compounds
radical damage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95912791A
Other languages
German (de)
French (fr)
Other versions
EP0754039A1 (en
Inventor
Donald L Bissett
Steven Alan Shaya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP0754039A1 publication Critical patent/EP0754039A1/en
Publication of EP0754039A4 publication Critical patent/EP0754039A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP95912791A 1994-04-08 1995-03-06 Methods of using iron chelating compounds to reduce free radical damage in mammals Withdrawn EP0754039A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22494994A 1994-04-08 1994-04-08
US224949 1994-04-08
PCT/US1995/002872 WO1995027485A1 (en) 1994-04-08 1995-03-06 Methods of using iron chelating compounds to reduce free radical damage in mammals

Publications (2)

Publication Number Publication Date
EP0754039A1 EP0754039A1 (en) 1997-01-22
EP0754039A4 true EP0754039A4 (en) 2002-07-17

Family

ID=22842898

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95912791A Withdrawn EP0754039A4 (en) 1994-04-08 1995-03-06 Methods of using iron chelating compounds to reduce free radical damage in mammals

Country Status (4)

Country Link
EP (1) EP0754039A4 (en)
JP (1) JP2001508755A (en)
CA (1) CA2186867C (en)
WO (1) WO1995027485A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2746015B1 (en) * 1996-03-18 1998-04-24 USE OF OCTOPIROX AS A DEPIGMENTANT AGENT
US5922761A (en) * 1996-09-06 1999-07-13 Medinox, Inc. Methods for in vivo reduction of iron levels and compositions useful therefor
TWI234467B (en) 1997-06-04 2005-06-21 Univ Michigan Composition for inhibiting photoaging of skin
EP1013272A1 (en) * 1998-12-23 2000-06-28 Biomedical Primate Research Centre (BPRC) Manipulation of the activity of a nitric oxide radical production pathway for the treatment of diseases associated with the presence of oxygen free radicals
NL1012825C2 (en) * 1999-08-13 2001-02-23 Faculteit Geneeskunde Universi Pharmaceutical for the treatment of viral infections, in particular of the human immunodeficiency virus (HIV).
JP2003528031A (en) * 1999-08-24 2003-09-24 ザ、プロクター、エンド、ギャンブル、カンパニー Method for lightening keratin tissue by topical application of oxime compound-containing composition
ITMI20022447A1 (en) * 2002-11-19 2004-05-20 Carlo Ghisalberti USE OF PYRIDINONS IN THE TREATMENT OF CAPILLARY PURPURE AND RELATED SKIN DISEASES.
US20120095058A1 (en) * 2003-12-03 2012-04-19 Hanauske-Abel H M Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses
UY30986A1 (en) 2007-03-28 2008-09-02 Apotex Technologies Inc FLUORINATED DEFERIPRONE DERIVATIVES
NZ588602A (en) * 2008-04-25 2012-08-31 Apotex Technologies Inc Liquid formulation for deferiprone with palatable taste
DK2448922T3 (en) 2009-07-03 2014-11-10 Apotex Technologies Inc FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDINE-4-ONER
AU2017307566B2 (en) * 2016-08-05 2023-06-15 Abfero Pharmaceuticals, Inc. Dosing regimens for treating metal-mediated conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0313305A2 (en) * 1987-10-22 1989-04-26 The Procter & Gamble Company Photoprotection compositions comprising chelating agents
WO1991016034A1 (en) * 1990-04-26 1991-10-31 The Procter & Gamble Company Chelator compositions comprising oxime compounds
WO1992016200A1 (en) * 1991-03-20 1992-10-01 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce The use of hydroxamic acid derivatives to inhibit viral replication

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0313305A2 (en) * 1987-10-22 1989-04-26 The Procter & Gamble Company Photoprotection compositions comprising chelating agents
WO1991016034A1 (en) * 1990-04-26 1991-10-31 The Procter & Gamble Company Chelator compositions comprising oxime compounds
WO1992016200A1 (en) * 1991-03-20 1992-10-01 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce The use of hydroxamic acid derivatives to inhibit viral replication

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1989, HALLIWELL B: "PROTECTION AGAINST TISSUE DAMAGE IN-VIVO BY DESFERRIOXAMINE WHAT IS ITS MECHANISM OF ACTION?", XP002187995, Database accession no. PREV199038052111 *
FREE RADICAL BIOLOGY & MEDICINE, vol. 7, no. 6, 1989, pages 645 - 652, XP001058483, ISSN: 0891-5849 *
See also references of WO9527485A1 *

Also Published As

Publication number Publication date
EP0754039A1 (en) 1997-01-22
JP2001508755A (en) 2001-07-03
CA2186867C (en) 2000-12-12
WO1995027485A1 (en) 1995-10-19
CA2186867A1 (en) 1995-10-19

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