EP0751949A4 - Anti-hepatitis b viral oligonucleotides - Google Patents

Anti-hepatitis b viral oligonucleotides

Info

Publication number
EP0751949A4
EP0751949A4 EP95903626A EP95903626A EP0751949A4 EP 0751949 A4 EP0751949 A4 EP 0751949A4 EP 95903626 A EP95903626 A EP 95903626A EP 95903626 A EP95903626 A EP 95903626A EP 0751949 A4 EP0751949 A4 EP 0751949A4
Authority
EP
European Patent Office
Prior art keywords
hepatitis
viral oligonucleotides
oligonucleotides
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95903626A
Other languages
German (de)
French (fr)
Other versions
EP0751949A1 (en
Inventor
Leslie R Coney
Catherine J Pachuk
Kyonggeun Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apollon Inc
Original Assignee
Apollon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apollon Inc filed Critical Apollon Inc
Publication of EP0751949A1 publication Critical patent/EP0751949A1/en
Publication of EP0751949A4 publication Critical patent/EP0751949A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
EP95903626A 1993-12-23 1994-12-01 Anti-hepatitis b viral oligonucleotides Withdrawn EP0751949A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17253893A 1993-12-23 1993-12-23
US172538 1993-12-23
PCT/US1994/013687 WO1995017414A1 (en) 1993-12-23 1994-12-01 Anti-hepatitis b viral oligonucleotides

Publications (2)

Publication Number Publication Date
EP0751949A1 EP0751949A1 (en) 1997-01-08
EP0751949A4 true EP0751949A4 (en) 1997-08-20

Family

ID=22628136

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95903626A Withdrawn EP0751949A4 (en) 1993-12-23 1994-12-01 Anti-hepatitis b viral oligonucleotides

Country Status (4)

Country Link
EP (1) EP0751949A4 (en)
JP (1) JPH09507062A (en)
CA (1) CA2178811A1 (en)
WO (1) WO1995017414A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856459A (en) * 1995-06-06 1999-01-05 Hybridon, Inc. Oligonucleotides specific for hepatitis B virus
ATE449194T1 (en) * 2003-12-16 2009-12-15 Bio Rad Pasteur OLIGONUCLEOTIDES FOR DETECTING HEPATITIS B VIRUSES
EP2699583A4 (en) 2011-04-21 2015-04-15 Isis Pharmaceuticals Inc Modulation of hepatitis b virus (hbv) expression
GB201408623D0 (en) * 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
CA3090391A1 (en) * 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated raltitrexed and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
C. SEEGER ET AL.: "Biochemical and genetic evidence for the Hepatitis B virus replication strategy", SCIENCE, vol. 232, no. 4749, 25 April 1986 (1986-04-25), pages 477 - 484, XP000672129 *
D. GANEM ET AL.: "The molecular biology of the hepatitis B viruses", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 56, 1987, pages 651 - 93, XP000672175 *
See also references of WO9517414A1 *
W-B. OFFENSPERGER ET AL.: "In vivo inhibition of duck hepatitis B virus replication and gene expression by phophorothioate modified antisense oligodeoxynucleotides.", EMBO J., vol. 12, no. 3, 1993, pages 1257 - 1262, XP000604664 *

Also Published As

Publication number Publication date
WO1995017414A1 (en) 1995-06-29
EP0751949A1 (en) 1997-01-08
CA2178811A1 (en) 1995-06-29
JPH09507062A (en) 1997-07-15

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Legal Events

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