EP0750630A4 - Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains - Google Patents
Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domainsInfo
- Publication number
- EP0750630A4 EP0750630A4 EP95914721A EP95914721A EP0750630A4 EP 0750630 A4 EP0750630 A4 EP 0750630A4 EP 95914721 A EP95914721 A EP 95914721A EP 95914721 A EP95914721 A EP 95914721A EP 0750630 A4 EP0750630 A4 EP 0750630A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- domains
- materials
- methods
- molecular interactions
- identifying inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/72—Fusion polypeptide containing domain for protein-protein interaction containing SH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20983594A | 1994-03-11 | 1994-03-11 | |
US209835 | 1994-03-11 | ||
US36983295A | 1995-01-06 | 1995-01-06 | |
US369832 | 1995-01-06 | ||
PCT/US1995/003208 WO1995024419A1 (en) | 1994-03-11 | 1995-03-13 | Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0750630A1 EP0750630A1 (en) | 1997-01-02 |
EP0750630A4 true EP0750630A4 (en) | 1998-01-07 |
Family
ID=26904553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95914721A Withdrawn EP0750630A4 (en) | 1994-03-11 | 1995-03-13 | Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0750630A4 (en) |
AU (1) | AU2159895A (en) |
WO (1) | WO1995024419A1 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2195629A1 (en) * | 1994-07-22 | 1996-02-08 | Andrew B. Sparks | Src sh3 binding peptides and methods of isolating and using same |
US6303574B1 (en) | 1994-07-22 | 2001-10-16 | The University Of North Carolina At Chapel Hill | Scr SH3 binding peptides and methods of isolating and using same |
US6184205B1 (en) * | 1994-07-22 | 2001-02-06 | University Of North Carolina At Chapel Hill | GRB2 SH3 binding peptides and methods of isolating and using same |
US5888763A (en) * | 1994-12-30 | 1999-03-30 | The Rockefeller University | Peptides specific for the first Crk-SH3 domain |
US6309820B1 (en) | 1995-04-07 | 2001-10-30 | University Of North Carolina At Chapel Hill | Polypeptides having a functional domain of interest and methods of identifying and using same |
CA2217641A1 (en) | 1995-04-07 | 1996-10-10 | Cytogen Corporation | Polypeptides having a functional domain of interest and methods of identifying and using same |
GB2311067B (en) * | 1996-01-08 | 2000-03-29 | Yamanouchi U K Ltd | Proline rich peptides derived from the rasgap-associated protein P62 |
WO1997031113A1 (en) * | 1996-02-23 | 1997-08-28 | Ariad Pharmaceuticals, Inc. | Cell-based assay |
US7279548B2 (en) | 1996-04-03 | 2007-10-09 | Cytogen Corporation | Identification and isolation of novel polypeptides having WW domains and methods of using same |
WO1997041255A1 (en) * | 1996-04-26 | 1997-11-06 | Massachusetts Institute Of Technology | Three-hybrid screening assay |
US6723694B1 (en) | 1997-05-21 | 2004-04-20 | The Children's Medical Center Corp. | Short peptides which selectively modulate intracellular signalling |
WO1999061467A2 (en) * | 1998-05-21 | 1999-12-02 | Mcgill University | Inhibition of the binding of protein tyrosine phosphatase pest to domains of signalling proteins |
JP2003500080A (en) | 1999-05-26 | 2003-01-07 | リセンチア エルテーデー | Methods and materials for producing SH3 domains with designed binding capacity |
US20020002239A1 (en) * | 1999-12-29 | 2002-01-03 | Tanaka Richard D. | Binding of polyamides to proteins having SH3 or WW domains |
CA2451741C (en) * | 2001-07-02 | 2014-02-18 | Elan Corporation, Plc | Peyers's patch and/or m-celle targeting ligands |
US7179784B2 (en) * | 2001-07-10 | 2007-02-20 | Massachusetts Institute Of Technology | Surfactant peptide nanostructures, and uses thereof |
DE60326735D1 (en) | 2002-08-02 | 2009-04-30 | Genesoft Pharmaceuticals Inc | BIARYL COMPOUNDS WITH ANTI-INFECTIVE EFFECT |
US7265129B2 (en) | 2002-10-25 | 2007-09-04 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
EP1587529A4 (en) | 2002-12-10 | 2009-08-12 | Oscient Pharmaceuticals Corp | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif |
CN101208353B (en) | 2003-06-20 | 2011-12-14 | 梅约医学教育与研究基金会 | Isoforms of brain natriuretic peptide |
BRPI0716416A2 (en) | 2006-08-08 | 2016-10-11 | Mayo Foundation | substantially pure polypeptide between 37 and 47 amino acid in length, isolated nucleic acid, vector: host cell and pharmaceutical composition |
WO2009026622A1 (en) * | 2007-08-24 | 2009-03-05 | Mylexa Pty Limited | Modulators of hypersensitivity reactions |
WO2009036448A2 (en) | 2007-09-15 | 2009-03-19 | Mayo Foundation For Medical Education And Research | Natriuretic peptide receptor-c agonists |
US8088890B2 (en) * | 2008-09-26 | 2012-01-03 | Fibrex Medical Research & Development Gmbh | Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition |
WO2013032784A1 (en) | 2011-08-30 | 2013-03-07 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides |
WO2013103896A1 (en) | 2012-01-06 | 2013-07-11 | Mayo Foundation For Medical Education And Research | Treating cardiovascular or renal diseases |
EP2752196A1 (en) * | 2013-01-03 | 2014-07-09 | Université Bordeaux Segalen | Selective nox-1 inhibitor peptides and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2054602A1 (en) * | 1991-10-31 | 1993-05-01 | Anthony Pawson | Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system |
US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
-
1995
- 1995-03-13 AU AU21598/95A patent/AU2159895A/en not_active Abandoned
- 1995-03-13 EP EP95914721A patent/EP0750630A4/en not_active Withdrawn
- 1995-03-13 WO PCT/US1995/003208 patent/WO1995024419A1/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
CA2054602A1 (en) * | 1991-10-31 | 1993-05-01 | Anthony Pawson | Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system |
Non-Patent Citations (5)
Title |
---|
GOUT, I. ET AL.: "Identification and functional characterization of SH3 domain-binding proteins", J. CELL BIOL., SUPPL. 0, (KEYSTONE SYMP. TRANSMEMB. SIG. TRANSDUCT., ISSN 0733-1959), vol. 18B, February 1994 (1994-02-01), pages 279, XP000652908 * |
GOUT, I. ET AL.: "The GTPase dynamin binds to and is activated by a subset of SH3 domains", CELL, vol. 75, 1993, pages 25 - 36, XP000652048 * |
LI, N. ET AL.: "Guanine-nucleotide-releasing factor hSos1 binds to Grb2 ...", NATURE, vol. 363, 1993, pages 85 - 88, XP002043217 * |
REN, R. ET AL.: "Identification of a ten-amino acid proline.rich SH3 binding site", SCIENCE, vol. 259, 1993, pages 1157 - 1161, XP000652050 * |
See also references of WO9524419A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0750630A1 (en) | 1997-01-02 |
AU2159895A (en) | 1995-09-25 |
WO1995024419A1 (en) | 1995-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19961008 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ZOLLER, MARK J. Inventor name: BOTFIELD, MARTYN C. Inventor name: BRUGGE, JOAN S. Inventor name: RICKLES, RICHARD J. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19971124 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE |
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17Q | First examination report despatched |
Effective date: 20000217 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20030906 |