EP0738154A4 - N-terminus modified analogs of lhrh - Google Patents
N-terminus modified analogs of lhrhInfo
- Publication number
- EP0738154A4 EP0738154A4 EP19940924100 EP94924100A EP0738154A4 EP 0738154 A4 EP0738154 A4 EP 0738154A4 EP 19940924100 EP19940924100 EP 19940924100 EP 94924100 A EP94924100 A EP 94924100A EP 0738154 A4 EP0738154 A4 EP 0738154A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- lhrh
- modified analogs
- terminus modified
- terminus
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pregnancy & Childbirth (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US103022 | 1987-09-30 | ||
US08/103,022 US5413990A (en) | 1993-08-06 | 1993-08-06 | N-terminus modified analogs of LHRH |
US08/279,677 US5502035A (en) | 1993-08-06 | 1994-07-27 | N-terminus modified analogs of LHRH |
US279677 | 1994-07-27 | ||
PCT/US1994/008678 WO1995004541A1 (en) | 1993-08-06 | 1994-07-29 | N-terminus modified analogs of lhrh |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0738154A4 true EP0738154A4 (en) | 1996-04-12 |
EP0738154A1 EP0738154A1 (en) | 1996-10-23 |
Family
ID=26799998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94924100A Withdrawn EP0738154A1 (en) | 1993-08-06 | 1994-07-29 | N-terminus modified analogs of lhrh |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0738154A1 (en) |
JP (2) | JP3662926B2 (en) |
CA (1) | CA2167834A1 (en) |
WO (1) | WO1995004541A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08504209A (en) * | 1992-12-04 | 1996-05-07 | アボツト・ラボラトリーズ | 6-position modified decapeptide LHRH antagonist |
US5635161A (en) * | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Aerosol drug formulations containing vegetable oils |
FR2797441B1 (en) * | 1999-07-30 | 2001-10-12 | Centre Nat Rech Scient | DERIVATIVES OF CYCLOHEXANE, CYCLOHEXENE, CYCLOHEXADIENE AND BENZENE FOR THE PREPARATION OF MANNOSE RECEPTOR LIGANDS |
US6462062B1 (en) | 2000-09-26 | 2002-10-08 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
GB0307777D0 (en) | 2003-04-04 | 2003-05-07 | Medical Res Council | Conjugate compounds |
MXPA06012391A (en) | 2004-04-30 | 2007-01-31 | Theraptosis S A | Caspase-2 inhibitors and their biological applications. |
PE20221323A1 (en) * | 2019-11-07 | 2022-09-09 | Chugai Pharmaceutical Co Ltd | COMPOSED OF CYCLIC PEPTIDES THAT HAVE INHIBITOR ACTION OF KRAS |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2233652A (en) * | 1986-10-13 | 1991-01-16 | Sandoz Ltd | Synthesis of peptide alcohols |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4690916A (en) * | 1984-11-13 | 1987-09-01 | Syntex (U.S.A.) Inc. | Nona and decapeptide analogs of LHRH useful as LHRH antagonists |
US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
US5110904A (en) * | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
-
1994
- 1994-07-29 JP JP50647395A patent/JP3662926B2/en not_active Expired - Fee Related
- 1994-07-29 CA CA002167834A patent/CA2167834A1/en not_active Abandoned
- 1994-07-29 EP EP94924100A patent/EP0738154A1/en not_active Withdrawn
- 1994-07-29 WO PCT/US1994/008678 patent/WO1995004541A1/en not_active Application Discontinuation
-
2004
- 2004-12-28 JP JP2004378980A patent/JP2005170950A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2233652A (en) * | 1986-10-13 | 1991-01-16 | Sandoz Ltd | Synthesis of peptide alcohols |
Non-Patent Citations (6)
Title |
---|
A.JANECKA ET AL: "The structural features of effective antagonists of the LHRH", AMINO ACIDS, vol. 6, no. 2, pages 111 - 130, XP000566196, DOI: doi:10.1007/BF00805840 * |
K.CHANNBASAVAIAH ET AL: "New analogs of lulliberin which inhibit ovulation in the rat", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 86, no. 4, ORLANDO, FL US, pages 1266 - 1273, XP024844257, DOI: doi:10.1016/0006-291X(79)90253-5 * |
K.FOLKERS ET AL: "Activities of antagonists of LHRH...", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, vol. 42b, TUBINGEN DE, pages 101 - 106 * |
K.FOLKERS ET AL: "Synthesis and bioassay of antagonists of LHRH...", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, vol. 37b, no. 8, TUBINGEN DE, pages 1075 - 1081 * |
S BAJUSZ ET AL: "New antagonists of LHRH", INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, vol. 32, COPENHAGEN DK, pages 425 - 435, XP008026213 * |
See also references of WO9504541A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2005170950A (en) | 2005-06-30 |
CA2167834A1 (en) | 1995-02-16 |
EP0738154A1 (en) | 1996-10-23 |
JP3662926B2 (en) | 2005-06-22 |
WO1995004541A1 (en) | 1995-02-16 |
JPH09501913A (en) | 1997-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A4 | Supplementary search report drawn up and despatched | ||
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19960124 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
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17Q | First examination report despatched |
Effective date: 19980929 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20001227 |