EP0732919A4 - Diphenyl-2-propenoates and homologs thereof useful for treating diseases associated with leukotriene b4 - Google Patents

Diphenyl-2-propenoates and homologs thereof useful for treating diseases associated with leukotriene b4

Info

Publication number
EP0732919A4
EP0732919A4 EP95905321A EP95905321A EP0732919A4 EP 0732919 A4 EP0732919 A4 EP 0732919A4 EP 95905321 A EP95905321 A EP 95905321A EP 95905321 A EP95905321 A EP 95905321A EP 0732919 A4 EP0732919 A4 EP 0732919A4
Authority
EP
European Patent Office
Prior art keywords
propenoates
leukotriene
homologs
diphenyl
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95905321A
Other languages
German (de)
French (fr)
Other versions
EP0732919A1 (en
Inventor
Robert A Daines
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0732919A1 publication Critical patent/EP0732919A1/en
Publication of EP0732919A4 publication Critical patent/EP0732919A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/75—Reactions with formaldehyde
EP95905321A 1993-12-09 1994-12-05 Diphenyl-2-propenoates and homologs thereof useful for treating diseases associated with leukotriene b4 Withdrawn EP0732919A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16460493A 1993-12-09 1993-12-09
US164604 1993-12-09
PCT/US1994/013966 WO1995015752A1 (en) 1993-12-09 1994-12-05 Diphenyl-2-propenoates and homologs thereof useful for treating diseases associated with leukotriene b4

Publications (2)

Publication Number Publication Date
EP0732919A1 EP0732919A1 (en) 1996-09-25
EP0732919A4 true EP0732919A4 (en) 1997-05-02

Family

ID=22595252

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95905321A Withdrawn EP0732919A4 (en) 1993-12-09 1994-12-05 Diphenyl-2-propenoates and homologs thereof useful for treating diseases associated with leukotriene b4

Country Status (8)

Country Link
EP (1) EP0732919A4 (en)
JP (1) JPH09506366A (en)
CN (1) CN1139880A (en)
AU (1) AU1398395A (en)
CA (1) CA2178634A1 (en)
NZ (1) NZ278484A (en)
WO (1) WO1995015752A1 (en)
ZA (1) ZA949786B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
EP2272817A4 (en) * 2008-04-11 2011-12-14 Inst Med Molecular Design Inc Pai-1 inhibitor
US8633245B2 (en) 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010780A1 (en) * 1991-12-06 1993-06-10 Smithkline Beecham Corporation Heterocyclic-substituted pyridine compounds and uses
WO1994000437A1 (en) * 1992-06-30 1994-01-06 Smithkline Beecham Corporation Pharmaceutical pyridine compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010780A1 (en) * 1991-12-06 1993-06-10 Smithkline Beecham Corporation Heterocyclic-substituted pyridine compounds and uses
WO1994000437A1 (en) * 1992-06-30 1994-01-06 Smithkline Beecham Corporation Pharmaceutical pyridine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9515752A1 *

Also Published As

Publication number Publication date
NZ278484A (en) 1998-02-26
EP0732919A1 (en) 1996-09-25
ZA949786B (en) 1995-10-11
WO1995015752A1 (en) 1995-06-15
CA2178634A1 (en) 1995-06-15
JPH09506366A (en) 1997-06-24
AU1398395A (en) 1995-06-27
CN1139880A (en) 1997-01-08

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