EP0714437A4 - Dna encoding inward rectifier, g-protein activated, mammalian, potassium kga channel and uses thereof - Google Patents

Dna encoding inward rectifier, g-protein activated, mammalian, potassium kga channel and uses thereof

Info

Publication number
EP0714437A4
EP0714437A4 EP94917452A EP94917452A EP0714437A4 EP 0714437 A4 EP0714437 A4 EP 0714437A4 EP 94917452 A EP94917452 A EP 94917452A EP 94917452 A EP94917452 A EP 94917452A EP 0714437 A4 EP0714437 A4 EP 0714437A4
Authority
EP
European Patent Office
Prior art keywords
mammalian
dna encoding
inward rectifier
protein activated
kga channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94917452A
Other languages
German (de)
French (fr)
Other versions
EP0714437A1 (en
Inventor
Henry A Lester
Nathan Dascal
Nancy F Lim
Wolfgang Schreibmayer
Norman Davidson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of EP0714437A1 publication Critical patent/EP0714437A1/en
Publication of EP0714437A4 publication Critical patent/EP0714437A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP94917452A 1993-05-21 1994-05-20 Dna encoding inward rectifier, g-protein activated, mammalian, potassium kga channel and uses thereof Withdrawn EP0714437A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/066,371 US5747278A (en) 1993-05-21 1993-05-21 DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
US66371 1993-05-21
PCT/US1994/005666 WO1994028131A1 (en) 1993-05-21 1994-05-20 Dna encoding inward rectifier, g-protein activated, mammalian, potassium kga channel and uses thereof

Publications (2)

Publication Number Publication Date
EP0714437A1 EP0714437A1 (en) 1996-06-05
EP0714437A4 true EP0714437A4 (en) 1997-05-07

Family

ID=22069084

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94917452A Withdrawn EP0714437A4 (en) 1993-05-21 1994-05-20 Dna encoding inward rectifier, g-protein activated, mammalian, potassium kga channel and uses thereof

Country Status (3)

Country Link
US (7) US5747278A (en)
EP (1) EP0714437A4 (en)
WO (1) WO1994028131A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747278A (en) * 1993-05-21 1998-05-05 California Institute Of Technology DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
GB9523497D0 (en) * 1995-11-16 1996-01-17 Ashcroft Frances Cell membrane protein and application thereof
FR2744730B1 (en) * 1996-02-08 1998-04-17 Centre Nat Rech Scient NEW FAMILY OF MAMMALIAN POTASSIUM CHANNELS, THEIR CLONING AND THEIR USE IN PARTICULAR FOR DRUG SCREENING
US7067625B1 (en) 1996-02-08 2006-06-27 Centre National De La Recherche Scientifique - Cnrs Isolated TWIK-1 potassium channel proteins
AU7902398A (en) * 1997-06-13 1999-01-04 Allelix Biopharmaceuticals Inc. Assay methods and compositions useful for measuring receptor ligand binding
CA2326777C (en) * 1998-04-01 2011-12-20 Nortran Pharmaceuticals Inc. Aminocyclohexyl ether compounds and uses thereof
AU4820399A (en) * 1998-06-29 2000-01-17 Hyseq, Inc. A chemokine receptor obtained from a cdna library of fetal liver-spleen
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
DE19920044A1 (en) * 1999-04-23 2000-10-26 Forschungsgesellschaft Genion Expression of bacterial potassium channels in eukaryotic host cells and their use in the identification of antibiotics
AU764158B2 (en) * 1999-07-20 2003-08-14 Regents Of The University Of California, The Odorant receptors
JP2003529332A (en) * 1999-10-04 2003-10-07 メルク エンド カムパニー インコーポレーテッド Human inward rectifier potassium channel subunit
US7524879B2 (en) * 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7057053B2 (en) * 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
WO2002066601A2 (en) * 2001-01-24 2002-08-29 Bristol-Myers Squibb Company Polynucleotide encoding a novel human potassium channel beta-subunit, k+betam2
US7034652B2 (en) * 2001-07-10 2006-04-25 Littlefuse, Inc. Electrostatic discharge multifunction resistor
DE10243599A1 (en) * 2002-09-19 2004-04-01 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Measuring device and method for a screening of cells immobilized on electrodes
US7345086B2 (en) * 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
US20090041841A1 (en) * 2003-05-02 2009-02-12 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
EP1560812B1 (en) * 2003-05-02 2006-05-10 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7674820B2 (en) * 2003-08-07 2010-03-09 Cardiome Pharma Corp. Ion channel modulating activity I
US7345087B2 (en) * 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
WO2005054863A2 (en) * 2003-11-22 2005-06-16 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled inwardly rectifying potassium channel (girk 3)
US8058304B2 (en) * 2004-04-01 2011-11-15 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
WO2005113011A2 (en) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
WO2006002295A1 (en) * 2004-06-22 2006-01-05 Thomas Abel Emergency utility vehicle
EP2404605B1 (en) * 2004-08-25 2015-04-22 Essentialis, Inc. Pharmaceutical formulations of potassium ATP channel openers and uses thereof
WO2006047849A1 (en) * 2004-11-01 2006-05-11 Institut De Cardiologie De Montreal Methods of identifying compounds that regulate acetylcholine-dependent potassium current in cardiac cells for treating atrial fibrillation.
CA2586918C (en) * 2004-11-08 2021-01-19 Cardiome Pharma Corp. Use of ion channel modulating compounds for treating acute atrial fibrillation in a human
ES2374963T3 (en) 2006-01-05 2012-02-23 Essentialis, Inc. SALES OF OPENING AGENTS OF THE ATP DEPENDENT CHANNEL OF ATP AND USES OF THE SAME.
US20090062264A1 (en) * 2007-07-02 2009-03-05 Cowen Neil M Salts of potassium atp channel openers and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747278A (en) * 1993-05-21 1998-05-05 California Institute Of Technology DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
US5492825A (en) * 1993-08-06 1996-02-20 The Regents Of The University Of California Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
AU1839695A (en) * 1994-02-08 1995-08-29 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Dna encoding atp-sensitive potassium channel proteins and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BROWN AM: "Regulation of heartbeat by G protein-coupled ion channels.", AM J PHYSIOL, DEC 1990, 259 (6 PT 2) PH1621-8, UNITED STATES, XP000610855 *
HO K ET AL: "CLONING AND EXPRESSION OF AN INWARDLY RECTIFYING ATP-REGULATED POTASSIUM CHANNEL", NATURE (LOND), 362 (6415). 1993. 31-37., XP002019316 *
KIRSCH G.E ET AL.: "Trypsin activation of atrial muscarinic K+ channels.", AM J PHYSIOL, JUL 1989, VOL 26 , N1 , PH334-8, UNITED STATES, XP000610831 *

Also Published As

Publication number Publication date
US5747278A (en) 1998-05-05
US5728535A (en) 1998-03-17
US5744324A (en) 1998-04-28
US6255459B1 (en) 2001-07-03
US20020086298A1 (en) 2002-07-04
US7083916B2 (en) 2006-08-01
WO1994028131A1 (en) 1994-12-08
US5734021A (en) 1998-03-31
US7138248B2 (en) 2006-11-21
EP0714437A1 (en) 1996-06-05
US20020052018A1 (en) 2002-05-02

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