EP0702557A4 - Inhibiteurs des cellules des muscles vasculaires lisses, a usage therapeutique - Google Patents

Inhibiteurs des cellules des muscles vasculaires lisses, a usage therapeutique

Info

Publication number
EP0702557A4
EP0702557A4 EP94916743A EP94916743A EP0702557A4 EP 0702557 A4 EP0702557 A4 EP 0702557A4 EP 94916743 A EP94916743 A EP 94916743A EP 94916743 A EP94916743 A EP 94916743A EP 0702557 A4 EP0702557 A4 EP 0702557A4
Authority
EP
European Patent Office
Prior art keywords
smooth muscle
muscle cells
vascular smooth
therapeutic inhibitor
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP94916743A
Other languages
German (de)
English (en)
Other versions
EP0702557A1 (fr
Inventor
Lawrence L Kunz
Richard A Klein
John M Reno
James C Metcalfe
Peter L Weissberg
Peter G Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poniard Pharmaceuticals Inc
Original Assignee
Poniard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poniard Pharmaceuticals Inc filed Critical Poniard Pharmaceuticals Inc
Priority to EP04077621A priority Critical patent/EP1510220B1/fr
Publication of EP0702557A1 publication Critical patent/EP0702557A1/fr
Publication of EP0702557A4 publication Critical patent/EP0702557A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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    • G—PHYSICS
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EP94916743A 1993-05-13 1994-05-12 Inhibiteurs des cellules des muscles vasculaires lisses, a usage therapeutique Ceased EP0702557A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04077621A EP1510220B1 (fr) 1993-05-13 1994-05-12 Inhibiteurs des cellules des muscles vasculaires lisses, à usage thérapeutique

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6245193A 1993-05-13 1993-05-13
US62451 1993-05-13
PCT/US1994/005266 WO1994026291A1 (fr) 1993-05-13 1994-05-12 Inhibiteurs des cellules des muscles vasculaires lisses, a usage therapeutique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP04077621A Division EP1510220B1 (fr) 1993-05-13 1994-05-12 Inhibiteurs des cellules des muscles vasculaires lisses, à usage thérapeutique

Publications (2)

Publication Number Publication Date
EP0702557A1 EP0702557A1 (fr) 1996-03-27
EP0702557A4 true EP0702557A4 (fr) 1998-06-03

Family

ID=22042574

Family Applications (2)

Application Number Title Priority Date Filing Date
EP04077621A Expired - Lifetime EP1510220B1 (fr) 1993-05-13 1994-05-12 Inhibiteurs des cellules des muscles vasculaires lisses, à usage thérapeutique
EP94916743A Ceased EP0702557A4 (fr) 1993-05-13 1994-05-12 Inhibiteurs des cellules des muscles vasculaires lisses, a usage therapeutique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP04077621A Expired - Lifetime EP1510220B1 (fr) 1993-05-13 1994-05-12 Inhibiteurs des cellules des muscles vasculaires lisses, à usage thérapeutique

Country Status (6)

Country Link
EP (2) EP1510220B1 (fr)
JP (1) JPH08510209A (fr)
AT (1) ATE401911T1 (fr)
CA (1) CA2162587C (fr)
DE (1) DE69435120D1 (fr)
WO (1) WO1994026291A1 (fr)

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US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ES2290074T3 (es) * 1993-07-19 2008-02-16 Angiotech Pharmaceuticals, Inc. Composiciones anti-angiogenicas que contienen taxol y un vehiculo no biodegradable y su uso.
BRPI9810945B8 (pt) * 1997-06-27 2021-05-25 Abraxis Bioscience Inc formulações de agentes farmacológicos, métodos para sua preparação e métodos para uso das mesmas
DE10115740A1 (de) 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
JP3990972B2 (ja) * 2001-11-20 2007-10-17 有限会社 キック 血管再狭窄防止薬及び該防止薬がコーティングされた血管内埋め込み器具
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
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EP0702557A1 (fr) 1996-03-27
DE69435120D1 (de) 2008-09-04
CA2162587C (fr) 2008-07-08
EP1510220A1 (fr) 2005-03-02
EP1510220B1 (fr) 2008-07-23
WO1994026291A1 (fr) 1994-11-24
JPH08510209A (ja) 1996-10-29
CA2162587A1 (fr) 1994-11-24
ATE401911T1 (de) 2008-08-15

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