EP0689450A4 - Potassium channel blocking compounds and their use - Google Patents

Potassium channel blocking compounds and their use

Info

Publication number
EP0689450A4
EP0689450A4 EP94911588A EP94911588A EP0689450A4 EP 0689450 A4 EP0689450 A4 EP 0689450A4 EP 94911588 A EP94911588 A EP 94911588A EP 94911588 A EP94911588 A EP 94911588A EP 0689450 A4 EP0689450 A4 EP 0689450A4
Authority
EP
European Patent Office
Prior art keywords
potassium channel
channel blocking
blocking compounds
compounds
potassium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94911588A
Other languages
German (de)
French (fr)
Other versions
EP0689450A1 (en
Inventor
Michael C Sanguinetti
Alan L Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
NPS Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Pharmaceuticals Inc filed Critical NPS Pharmaceuticals Inc
Publication of EP0689450A1 publication Critical patent/EP0689450A1/en
Publication of EP0689450A4 publication Critical patent/EP0689450A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Insects & Arthropods (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Agronomy & Crop Science (AREA)
EP94911588A 1993-03-18 1994-03-14 Potassium channel blocking compounds and their use Withdrawn EP0689450A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3338893A 1993-03-18 1993-03-18
US33388 1993-03-18
PCT/US1994/002750 WO1994021278A1 (en) 1993-03-18 1994-03-14 Potassium channel blocking compounds and their use

Publications (2)

Publication Number Publication Date
EP0689450A1 EP0689450A1 (en) 1996-01-03
EP0689450A4 true EP0689450A4 (en) 1997-05-21

Family

ID=21870134

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94911588A Withdrawn EP0689450A4 (en) 1993-03-18 1994-03-14 Potassium channel blocking compounds and their use

Country Status (6)

Country Link
EP (1) EP0689450A4 (en)
JP (1) JPH08508250A (en)
CN (1) CN1125402A (en)
AU (1) AU6407594A (en)
CA (1) CA2158051A1 (en)
WO (1) WO1994021278A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE301190T1 (en) * 2000-05-10 2005-08-15 Centre Nat Rech Scient PROTON DEPENDENT NA+CHANNEL INHIBITING POLYPEPTIDE
JP2006516884A (en) 2002-09-23 2006-07-13 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Isolation and use of ryanodine receptor
BRPI0605484A8 (en) 2006-11-21 2017-03-07 Fund Amparo Pesquisa Estado Minas Gerais Fapemig PH(ALPHA)1B TOXIN, PH(ALPHA)1B TOXIN GENE CDNA, PHARMACEUTICAL COMPOSITIONS CONTAINING PH(ALPHA)1B TOXIN, PROCESS FOR OBTAINING THEM, PROCESS FOR OBTAINING THE CDNA, AND PRODUCT
CN106146639B (en) * 2015-04-21 2019-05-03 湖南师范大学 A kind of potassium channel inhibitors from Macrothele raveni venom
US11969197B2 (en) 2017-10-13 2024-04-30 Mayo Foundation For Medical Education And Research Methods and devices for electroporation for treatment of ventricular fibrillation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
WO1994010195A1 (en) * 1992-10-30 1994-05-11 Pfizer Inc. Calcium channel blocking polypeptides from heteropoda venatoria

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
WO1994010195A1 (en) * 1992-10-30 1994-05-11 Pfizer Inc. Calcium channel blocking polypeptides from heteropoda venatoria

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LAVRETSKY E.ET AL.: "A group of Potassium-Channel Blockers-Acetylcholine Releasers: New Potentials for Alzheimer Disease? A Reviewse", JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, vol. 12, no. 2, April 1992 (1992-04-01), pages 110 - 118, XP000647340 *
See also references of WO9421278A1 *

Also Published As

Publication number Publication date
AU6407594A (en) 1994-10-11
EP0689450A1 (en) 1996-01-03
JPH08508250A (en) 1996-09-03
CN1125402A (en) 1996-06-26
CA2158051A1 (en) 1994-09-29
WO1994021278A1 (en) 1994-09-29

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19951018

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

Effective date: 19970407

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STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 19981001