EP0681478A4 - Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres - Google Patents

Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres

Info

Publication number
EP0681478A4
EP0681478A4 EP94911515A EP94911515A EP0681478A4 EP 0681478 A4 EP0681478 A4 EP 0681478A4 EP 94911515 A EP94911515 A EP 94911515A EP 94911515 A EP94911515 A EP 94911515A EP 0681478 A4 EP0681478 A4 EP 0681478A4
Authority
EP
European Patent Office
Prior art keywords
biodegradable
diseases caused
vaccines against
against diseases
biocompatible microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94911515A
Other languages
German (de)
French (fr)
Other versions
EP0681478A1 (en
Inventor
Robert H Reid
Edgar C Boedeker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Government
Original Assignee
US Government
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Government filed Critical US Government
Publication of EP0681478A1 publication Critical patent/EP0681478A1/en
Publication of EP0681478A4 publication Critical patent/EP0681478A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EP94911515A 1993-03-22 1994-03-09 Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres Withdrawn EP0681478A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3494993A 1993-03-22 1993-03-22
US34949 1993-03-22
PCT/US1994/002536 WO1994021289A1 (en) 1993-03-22 1994-03-09 Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres

Publications (2)

Publication Number Publication Date
EP0681478A1 EP0681478A1 (en) 1995-11-15
EP0681478A4 true EP0681478A4 (en) 2000-09-06

Family

ID=21879657

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94911515A Withdrawn EP0681478A4 (en) 1993-03-22 1994-03-09 Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres

Country Status (3)

Country Link
EP (1) EP0681478A4 (en)
AU (1) AU6400194A (en)
WO (1) WO1994021289A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019263A1 (en) * 1991-04-24 1992-11-12 The United States Of America, As Represented By The Secretary Of The Army Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019263A1 (en) * 1991-04-24 1992-11-12 The United States Of America, As Represented By The Secretary Of The Army Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BOYLAN M ET AL: "NUCLEOTIDE SEQUENCE OF THE GENE ENCODING THE MAJOR SUBUNIT OF CS3 FIMBRIAE OF ENTEROTOXIGENIC ESCHERICHIA-COLI", INFECTION AND IMMUNITY 1988, vol. 56, no. 12, 1988, pages 3297 - 3300, XP000909617, ISSN: 0019-9567 *
EDELMAN ROBERT ET AL: "Immunization of rabbits with enterotoxigenic Escherichia coli colonization factor antigen (CFA/I) encapsulated in biodegradable microspheres of poly (lactide-co-glycolide).", INTERNATIONAL CONFERENCE ON VACCINES FOR ENTERIC DISEASES;CAMBRIDGE, ENGLAND, UK; APRIL 13-15, 1992, vol. 11, no. 2, 1993, Vaccine 1993, pages 155 - 158, XP000886975, ISSN: 0264-410X *
LEVINE M M ET AL: "COLI SURFACE ANTIGENS 1 AND 3 OF COLONIZATION FACTOR ANTIGEN II POSITIVE ENTERO TOXIGENIC ESCHERICHIA-COLI MORPHOLOGY PURIFICATION AND IMMUNE RESPONSES IN HUMANS", INFECTION AND IMMUNITY 1984, vol. 44, no. 2, 1984, pages 409 - 420, XP000886967, ISSN: 0019-9567 *
NELLORE R ET AL: "APPLICATION OF BIODEGRADABLE MICROSPHERES TO HEPATITIS B SURFACE ANTIGEN VACCINATION SYSTEM", PHARMACEUTICAL RESEARCH (NEW YORK) 1991, vol. 8, no. 10 SUPPL., 1991, pages S151, XP002026578, ISSN: 0724-8741 *
REID R ET AL: "Colonization factor antigen/II (CFA/II) incorporated into biodegradable, biocompatible microspheres as an intestinal vaccine against enterotoxigenic Escherichia coli: A safety, immunization, and efficacy human study.", JOINT MEETING OF THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AND THE CLINICAL IMMUNOLOGY SOCIETY;DENVER, COLORADO, USA; MAY 21-25, 1993, vol. 150, no. 8 PART 2, 1993, Journal of Immunology 1993, pages 323A, XP000909651, ISSN: 0022-1767 *
REID R H ET AL: "Preclinical evaluation of microencapsulated CFA/II oral vaccine against enterotoxigenic Escherichia coli.", INTERNATIONAL CONFERENCE ON VACCINES FOR ENTERIC DISEASES;CAMBRIDGE, ENGLAND, UK; APRIL 13-15, 1992, vol. 11, no. 2, 1993, Vaccine 1993, pages 159 - 167, XP000886976, ISSN: 0264-410X *
See also references of WO9421289A1 *

Also Published As

Publication number Publication date
EP0681478A1 (en) 1995-11-15
AU6400194A (en) 1994-10-11
WO1994021289A1 (en) 1994-09-29

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