EP0656787A4 - Method of inhibiting reduction of disulfide bonds. - Google Patents

Method of inhibiting reduction of disulfide bonds.

Info

Publication number
EP0656787A4
EP0656787A4 EP19930920204 EP93920204A EP0656787A4 EP 0656787 A4 EP0656787 A4 EP 0656787A4 EP 19930920204 EP19930920204 EP 19930920204 EP 93920204 A EP93920204 A EP 93920204A EP 0656787 A4 EP0656787 A4 EP 0656787A4
Authority
EP
European Patent Office
Prior art keywords
disulfide bonds
inhibiting reduction
inhibiting
reduction
disulfide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19930920204
Other languages
German (de)
French (fr)
Other versions
EP0656787A1 (en
Inventor
Hugues J-P Ryser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston University
Original Assignee
Boston University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston University filed Critical Boston University
Publication of EP0656787A4 publication Critical patent/EP0656787A4/en
Publication of EP0656787A1 publication Critical patent/EP0656787A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/305—Mercury compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP93920204A 1992-08-19 1993-08-18 Method of inhibiting reduction of disulfide bonds Withdrawn EP0656787A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US93236992A 1992-08-19 1992-08-19
US932369 1992-08-19
US5219493A 1993-04-22 1993-04-22
US52194 1993-04-22
PCT/US1993/007805 WO1994004185A2 (en) 1992-08-19 1993-08-18 Method of inhibiting reduction of disulfide bonds

Publications (2)

Publication Number Publication Date
EP0656787A4 true EP0656787A4 (en) 1994-04-15
EP0656787A1 EP0656787A1 (en) 1995-06-14

Family

ID=26730314

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93920204A Withdrawn EP0656787A1 (en) 1992-08-19 1993-08-18 Method of inhibiting reduction of disulfide bonds

Country Status (2)

Country Link
EP (1) EP0656787A1 (en)
WO (1) WO1994004185A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT100914A (en) * 1991-09-30 1993-10-29 Jess G Thoene USE OF COMPOUNDS ABLE TO SUFFER A MIXED DISSOLFURET EXCHANGE, WITH A DISSULFURET LIGACATION, IN THE TREATMENT OF HIV INFECTION
US5554655A (en) * 1991-09-30 1996-09-10 Jess G. Thoene Method of treating HIV infection
AU7931094A (en) * 1993-10-15 1995-05-04 Jess G. Thoene Prevention of hiv infection
US5725870A (en) * 1993-10-15 1998-03-10 Thoene; Jess G. Methods, composites and articles for contraception
US5532154A (en) * 1994-03-21 1996-07-02 Research Development Foundation Mutated alpha virus
US6977142B2 (en) * 2003-09-23 2005-12-20 Agy Therapeutics, Inc. High-throughput turbidometric assay for screening inhibitors of protein disulfide isomerase activity
PL227562B1 (en) 2011-09-23 2017-12-29 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Application of the bacitracin antibiotic for the hydrolytic degradation of RNA

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9404185A3 *

Also Published As

Publication number Publication date
WO1994004185A2 (en) 1994-03-03
WO1994004185A3 (en) 2004-04-29
EP0656787A1 (en) 1995-06-14

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19950301

AK Designated contracting states

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Designated state(s): FR GB

17Q First examination report despatched

Effective date: 19960201

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20000513

D17D Deferred search report published (deleted)