EP0644785A1 - Arrangement and method for dispensing preservative-free nasal sprays and similar preparations - Google Patents

Arrangement and method for dispensing preservative-free nasal sprays and similar preparations

Info

Publication number
EP0644785A1
EP0644785A1 EP93913725A EP93913725A EP0644785A1 EP 0644785 A1 EP0644785 A1 EP 0644785A1 EP 93913725 A EP93913725 A EP 93913725A EP 93913725 A EP93913725 A EP 93913725A EP 0644785 A1 EP0644785 A1 EP 0644785A1
Authority
EP
European Patent Office
Prior art keywords
cap
dispensing
protective cap
cap according
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP93913725A
Other languages
German (de)
French (fr)
Other versions
EP0644785B1 (en
Inventor
Kurt Nilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of EP0644785A1 publication Critical patent/EP0644785A1/en
Application granted granted Critical
Publication of EP0644785B1 publication Critical patent/EP0644785B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps

Definitions

  • Fig 2 illustrates a conventional protective cap for a nasal spray bottle
  • Fig 3a illustrates a first embodiment of a protective cap according to the invention in a side view
  • Figs 5a - 5c illustrate a second embodiment of a protective cap according to the invention in views corresponding to the views in figs 3a - 3c
  • a typical size of the cap may be as follows: Height 29 mm, Base diameter 13 mm and Top diameter 11 mm, giving a total outside area of 1100 mm 2 .
  • the surface 9 of the cap is provided with longitudinal slits 8.
  • the end wall 10 of the cap is provided with axial holes or vents 7. Consequently the olive will dry quickly when the cap has been replaced after use since the air has free access to the olive. As mentioned above, the conditions for bacterial growth are unfavourable when the olive is dry.
  • the total area of the slits and the holes is at least 50 mm 2 , i.e. a ratio of about 1:26, preferably 1:22 relative to the outer surface.
  • Figs 5 and 6 illustrate embodiments not utilizing longitudinal slits.
  • the embodiment according to figs 5a illustrate embodiments not utilizing longitudinal slits. The embodiment according to figs 5a

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)

Abstract

The invention relates to a method for keeping the dispensing parts on a device for administering a sterile preparation for local treatment containing a preservative-free preparation free from bacterial growth. This is achieved in that the dispensing part is allowed to dry quickly after each use. The invention is also directed towards a cap to be used in this method.

Description

Arrangement and method for dispensing preservative- free nasal sprays and similar preparations.
Field of the invention.
The present invention relates to devices for administering liquid, sterile preparations for local treatment, such as nasal sprays and eye drops and more particularly to an arrangement and a method for facilitating the use of sterile preparations not containing preservatives.
Background of the invention.
Nasal sprays are usually administered by means of a bottle made of plastic or glass or another equivalent receptacle containing a solution to be sprayed into the nostril. The bottle is provided with a part for dispensing the preparation to the location to be treated, normally a nasal tube or olive which is to be inserted into the nostril. The solution then is squirted into the nostril by any suitable means, for instance by means of a pump, by deformation of the bottle or by utilizing a suitable propellant. After use the olive is covered by a cap in order to protect the olive from damages, dirt and contamination.
After use, a small amount of the solution and possibly some mucus from the nostril usually remains on the olive. These remains may form a base for the growth of bacteria and other undesirable microorganisms, since the solution not necessarily must be an antiseptic solution and sometimes even contains ingredients that may serve as nutrients for the bacteria. These bacteria then will be introduced into the nostril next time the nasal spray device is used, by the same user or by another. This of course is undesirable. The bacteria may also contaminate the contents of the bottle since there may be a direct connection between the olive and the interior of the bottle, at least during some stage of the use.
To avoid these problems normally a preservative intended to prevent the growth of bacteria is added to the solution. This however has other disadvantages, among others the inhibitory effects on cilia movement, granolyte chemotaxis or that the user may have a low tolerance against the preservatives normally used or against antiseptic agents or additives in general. Therefore it is desirable to provide nasal sprays which are free from preservatives and similar additives.
There are similar problems relating to the dispensing of eye drops, since it is essential that eye drops are sterile when administered to the eye.
Brief description of the inventive concept.
The solution of this problem as envisaged by the present invention is to provide a method which allows the part for dispensing the preparation to dry quickly as well as to provide a protective cap for said part which allows the part to dry quickly, as set forth in the appended claims. It has been found that it is sufficient to keep the part in question dry in order to keep it free from bacterial growth. By this means the part can be kept free to a degree which is sufficient in the context even if the preparation does not contain any preservatives.
Short description of the drawings.
Fig 1 illustrates a typical spray bottle for nasal sprays,
Fig 2 illustrates a conventional protective cap for a nasal spray bottle,
Fig 3a illustrates a first embodiment of a protective cap according to the invention in a side view,
Fig 3b illustrates the embodiment of fig 3a in a top view,
Fig 3c shows a section along line III - III in fig 3b,
Figs 4a - 4c illustrate the embodiment of figs 3a - 3c in a slightly changed form in views corresponding to the views in figs 3a - 3c,
Figs 5a - 5c illustrate a second embodiment of a protective cap according to the invention in views corresponding to the views in figs 3a - 3c,
Figs 6a - 6c illustrate the embodiment of figs 5a - 5c in a slightly changed form in views corresponding to the views in figs 3a - 3c,
Figs 7a - 7c illustrate a third embodiment of a protective cap according to the invention combining the features illustrated in figs 3 and 5 in views corresponding to the views in figs 3a - 3c, Figs 8a - 8c illustrate a fourth embodiment of a protective cap according to the invention combining the features illustrated in figs 3 and 6 in views corresponding to the views in figs 3a - 3c.
Detailed description of preferred embodiments of the invention.
In the description below and in the drawings details which are identical will be designated with the same reference signs.
Figs 1 and 2 illustrate a conventional device for administering a nasal spray of the kind containing a pump mechanism (not shown) for ejecting the nasal spray solution. The device comprises a bottle 1 having a closure cap 2 with a nasal tube or olive 3. The olive is covered by a protective cap 4, illustrated in Fig 2, when the device is not in use. The protective cap is provided with a conical side wall and an end wall. The other constructional details of the device are of no particular concern in the context apart from the olive and its protective cap and are therefore not described in detail.
The outlet for the nasal solution is located at the tip of the olive (at 5) . When the spray device has been used usually some droplets of nasal solution remain in the area close to the outlet. Since these droplets normally are contaminated by bacteria or similar originating from the nostril of the user, there is a great risk for an excessive growth of bacteria in the droplets if a solution not containing a preservative is used. Nasal spray solutions are normally not antiseptic. The embodiment according to the invention illustrated in figs 3a - 3c comprises a protective cap 6 which substantially has the shape of a truncated cone with a small top angle. The protective cap 6 is provided with beads or lugs 11 for securing the cap to the closure cap 2. A typical size of the cap may be as follows: Height 29 mm, Base diameter 13 mm and Top diameter 11 mm, giving a total outside area of 1100 mm2. The surface 9 of the cap is provided with longitudinal slits 8. To facilitate the air circulation through the slits and around the olive, the end wall 10 of the cap is provided with axial holes or vents 7. Consequently the olive will dry quickly when the cap has been replaced after use since the air has free access to the olive. As mentioned above, the conditions for bacterial growth are unfavourable when the olive is dry.
In a protective cap of the size described above it is preferred that the total area of the slits and the holes is at least 50 mm2, i.e. a ratio of about 1:26, preferably 1:22 relative to the outer surface.
In a slightly changed embodiment illustrated in Figs 4a
- 4c, the protective cap 6 is provided with longitudinal slits 12 extending all the way down to the base of the protective cap. Apart from this feature, which further enhances the circulation of air around the nasal olive, this embodiment is identical with the embodiment described above in connection with Figs 3a - 3c.
Figs 5 and 6 illustrate embodiments not utilizing longitudinal slits. The embodiment according to figs 5a
- 5c comprises a protective cap 13 with an unbroken side wall 14. The cap is provided with an end wall 15 having a central opening 16. An annular, circumferential bead 17 is arranged on the inside wall of the cap a slight distance from the opening 16. A porous, absorbent, comparatively thin and slightly concave disc 18 having a diameter which is slightly larger than the inside diameter of the cap adjacent the bead 17 is snapped into place past the bead. The disc 18 will in this way be held under tension by means of the bead 17 and the part of the inside of the wall located above the bead 17. The bead 17 is located such a distance away from the end wall 15 that the disc 18 comes into direct contact with the tip 5 of the olive 3 when the protective cap is placed on the bottle. Any liquid on the tip of the olive then will be absorbed by the disc by means of capillary forces. In this way the liquid will be distributed over a large area which means that the liquid will evaporate quickly. In this way the olive will be kept effectively dry. This is essential in order to prevent growth of contaminating bacteria, particularly bacteria being Gram-negative. Examples of suitable absorbents are cellulose in different forms such as filtering paper, cigarette filters, sponges or cotton, and different plastics materials in the form of woven or non-woven fibers or in the form of sponges, such as polyamides, polyvinylacetate, polyesters.
In order to ensure that the absorbent material is kept in a proper hygienic condition, the material may be impregnated with a suitable preservative, for instance chlorhexidine acetate.
A slightly altered form of the embodiment according to Figs 5a - 5c is illustrated in Figs 6a - 6c. In this embodiment the disc has been replaced by an absorbent plug 19 held by projections 20. The materials of the plug may be the same and may have the same physical form and properties as the materials in the disc described above. At present ethylenevinylacetate foam or sintered polyethylene seem to be the most suitable materials. The projections 20 are not absolutely necessary, since the plug for instance can be glued to the cap or be bonded to the cap at the moulding thereof. Depending on the materials, a simple press fit also may be conceivable.
The two latter embodiments are particularly suitable in nasal spray bottles mainly intended to be carried in the users pocket, handbag or similar since these embodiments are more effective in keeping out dirt etc than the previous embodiments.
An embodiment which would belong to the same category and which essentially have the same properties as the embodiments according to figs 5 and 6 is an embodiment wherein the entire protective cap is made of a fibrous, absorbent material. This embodiment is however not illustrated. An alternative embodiment would be to make the cap of a relatively rigid fibermaterial which is permeable in regard of vapour, for instance glass- fibre, felt or gauze.
Figs 7a - 7c and 8a - 8c illustrate embodiments of the invention which essentially are a combination of the embodiment according to Figs 3a - 3c with the embodiments according to Figs 5a - 5c and Figs 6a - 6c respectively.
Figs 7a - 7c thus illustrate a cap 6 comprising a side wall 9 provided with longitudinal slits 8, an end wall 10 provided with holes 7 as well as with beads 11. The cap 6 additionally is provided with a disc 18' mounted in a similar way as the disc 18 in the embodiment according to Figs 5a - 5c.
Figs 8a - 8b illustrate a cap 6' comprising a side wall 9' provided with longitudinal slits 8', an end wall 15' provided with a hole 16' as well as with beads ll'. The cap 6' furthermore is provided with lugs 20' for holding a porous plug 19'.
It is also conceivable to provide an ordinary protective cap with a desiccant, such as silica gel. In this case the cap must form an airtight seal against the bottle since the desiccant otherwise would absorb moisture from the ambient air and soon become ineffective.
As mentioned in the introduction, the basic principle also is applicable to other liquid, sterile, preservative-free preparations for local treatment that are dispensed from containers onto the place to be treated, for instance eye drops being dispensed from a plastic squeeze bottle having a dispensing spout normally covered with a protective cap when the bottle is not in use.

Claims

1. Method for keeping the dispensing part on a device for administering a liquid, sterile, preservative-free preparation for local treatment free from bacterial growth, c h a r a c t e r i z e d in that the dispensing part is allowed to dry quickly after each use.
2. Protective cap (6, 6' , 13) for the dispensing part (3) for a device for dispensing a liquid, sterile, preservative-free preparation free from bacterial growth, c h a r a c t e r i z e d in that the cap is provided with means allowing the nasal tube to dry.
3. Protective cap according to claim 2 , c h a r a c t e r i z e d in that the cap (6) is provided with openings (7, 8, 12) allowing free access for the ambient air to said part (3) for dispensing said preparation.
4. Protective cap according to claim 3 , c h a r a c t e r i z e d in that said cap is shaped as a truncated cone or pyramid having a top end wall (10) , said openings being in the form of longitudinal slits (8, 12), preferably combined with at least one opening (7) in said top end wall (10) .
5. Protective cap according to any one of claims 3 or 4, c h a r a c t e r i z e d in that the ratio of the openings (7, 8, 12) relative to the total outer surface of the cap is about 1:22.
6. Protective cap according to claim 2, c h a r a c t e r i z e d in that the cap (6, 6', 13) is provided with absorbent materials (18, 18', 19, 19') contacting the dispensing outlet (5) of said dispensing part (3) when the cap is placed in its normal position covering the dispensing part, at least some parts of said absorbent materials being in contact with the ambient air.
7. Protective cap according to claim 6, c h a r a c t e r i z e d in that said cap (6, 6', 13) has the shape of a truncated cone or pyramid having top end wall (10, 15, 15') which is provided with at least one opening (7, 16, 16'), said absorbent materials being located in the vicinity of said opening in said end wall.
8. Protective cap according to claim 7, c h a r a c t e r i z e d in that said absorbent material is in the shape of a plug (19, 19') held by projections (20, 20') located on the inside of said cap, said plug (19, 19') preferably being made in the shape of a sponge of a suitable material, for instance ethylenevinylacetate foam or sintered polyethylene.
9. Protective cap according to claim 7, c h a r a c t e r i z e d in that said absorbent material is in the shape of an elastic disc (18, 18') held by a circumferential bead (17, 17') located on the inside of said cap, said disc having a diameter which is slightly larger than the inside diameter of the cap adjacent said bead (17, 17'), said disc thus being tensioned against the inside of the cap, thereby obtaining a concave shape, the convex side of the disc being oriented towards said dispensing outlet (5) .
10. Protective cap according to any one of claims 5 - 9, c h a r a c t e r i z e d in that the cap also is provided with openings (8, 12) allowing free access for the ambient air to the dispensing part. AMENDED CLAIMS
[received by the International Bureau on 28 October 1993 (28.10.93); original claims 1-10 replaced by amended claims 1-10 (2 pages)]
1. Method for keeping the dispensing part on a device for administering a liquid, sterile, preservative-free preparation for local treatment free from bacterial growth, c h a r a c t e r i z e d in that the dispensing part is allowed to dry quickly after each use.
2. Protective cap (6, 6', 13) for the dispensing part (3) for a device for dispensing a liquid, sterile, preservative-free preparation free from bacterial growth, c h a r a c t e r i z e d in that the cap is provided with means allowing said dispensing part to dry.
3. Protective cap according to claim 2, c h a r a c t e r i z e d in that the cap (6) is provided with openings (7, 8, 12) allowing free access for the ambient air to said part (3) for dispensing said preparation.
4. Protective cap according to claim 3, c h a r a c t e r i z e d in that said cap is shaped as a truncated cone or pyramid having a top end wall (10) , said openings being in the form of longitudinal slits (8, 12) , preferably combined with at least one opening (7) in said top end wall (10) .
5. Protective cap according to any one of claims 3 or 4, c h a r a c t e r i z e d in that the ratio of the openings (7, 8, 12) relative to the total outer surface of the cap is about 1:22.
6. Protective cap according to claim 2, c h a r a c t e r i z e d in that the cap (6, 6', 13) is provided with absorbent materials (18, 18', 19, 19') contacting the dispensing outlet (5) of said dispensing part (3) when the cap is placed in its normal position covering the dispensing part, at least some parts of said absorbent materials being in contact with the ambient air.
7. Protective cap according to claim 6, c h a r a c t e r i z e d in that said cap (6, 6', 13) has the shape of a truncated cone or pyramid having top end wall (10, 15, 15') which is provided with at least one opening (7, 16, 16'), said absorbent materials being located in the vicinity of said opening in said end wall.
8. Protective cap according to claim 7 , c h a r a c t e r i z e d in that said absorbent material is in the shape of a plug (19, 19') held by projections (20, 20') located on the inside of said cap, said plug (19, 19') preferably being made in the shape of a sponge of a suitable material, for instance ethylenevinylacetate foam or sintered polyethylene.
9. Protective cap according to claim 7, c h a r a c t e r i z e d in that said absorbent material is in the shape of an elastic disc (18, 18') held by a circumferential bead (17, 17') located on the inside of said cap, said disc having a diameter which is slightly larger than the inside diameter of the cap adjacent said bead (17, 17'), said disc thus being tensioned against the inside of the cap, thereby obtaining a concave shape, the convex side of the disc being oriented towards said dispensing outlet (5) .
10. Protective cap according to any one of claims 5 - 9, c h a r a c t e r i z e d in that the cap also is provided with openings (8, 12) allowing free access for the ambient air to the dispensing part.
EP93913725A 1992-06-03 1993-06-01 Arrangement for dispensing preservative-free nasal sprays and similar preparations Expired - Lifetime EP0644785B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9201718 1992-06-03
SE9201718A SE9201718D0 (en) 1992-06-03 1992-06-03 NASAL SPRAY DEVICE
PCT/SE1993/000485 WO1993024164A1 (en) 1992-06-03 1993-06-01 Arrangement and method for dispensing preservative-free nasal sprays and similar preparations

Publications (2)

Publication Number Publication Date
EP0644785A1 true EP0644785A1 (en) 1995-03-29
EP0644785B1 EP0644785B1 (en) 1999-04-21

Family

ID=20386404

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93913725A Expired - Lifetime EP0644785B1 (en) 1992-06-03 1993-06-01 Arrangement for dispensing preservative-free nasal sprays and similar preparations

Country Status (15)

Country Link
US (1) US6116468A (en)
EP (1) EP0644785B1 (en)
JP (1) JP3413804B2 (en)
AT (1) ATE179084T1 (en)
AU (1) AU674686B2 (en)
CA (1) CA2136740C (en)
DE (1) DE69324583T2 (en)
DK (1) DK0644785T3 (en)
ES (1) ES2132238T3 (en)
FI (1) FI111809B (en)
GR (1) GR3030730T3 (en)
NO (1) NO310180B1 (en)
NZ (1) NZ253381A (en)
SE (1) SE9201718D0 (en)
WO (1) WO1993024164A1 (en)

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AU4365693A (en) 1993-12-30
CA2136740A1 (en) 1993-12-09
JPH07507221A (en) 1995-08-10
FI945711A0 (en) 1994-12-02
CA2136740C (en) 2005-03-29
NZ253381A (en) 1996-06-25
NO944579L (en) 1994-11-29
JP3413804B2 (en) 2003-06-09
GR3030730T3 (en) 1999-11-30
AU674686B2 (en) 1997-01-09
ATE179084T1 (en) 1999-05-15
EP0644785B1 (en) 1999-04-21
DE69324583T2 (en) 1999-09-23
WO1993024164A1 (en) 1993-12-09
US6116468A (en) 2000-09-12
NO944579D0 (en) 1994-11-29
ES2132238T3 (en) 1999-08-16
DE69324583D1 (en) 1999-05-27
FI111809B (en) 2003-09-30
SE9201718D0 (en) 1992-06-03
DK0644785T3 (en) 1999-10-25
FI945711A (en) 1994-12-02
NO310180B1 (en) 2001-06-05

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