EP0637915A4 - Compositions and methods for regulating il-6 production in vivo. - Google Patents

Compositions and methods for regulating il-6 production in vivo.

Info

Publication number
EP0637915A4
EP0637915A4 EP93910928A EP93910928A EP0637915A4 EP 0637915 A4 EP0637915 A4 EP 0637915A4 EP 93910928 A EP93910928 A EP 93910928A EP 93910928 A EP93910928 A EP 93910928A EP 0637915 A4 EP0637915 A4 EP 0637915A4
Authority
EP
European Patent Office
Prior art keywords
vivo
regulating
compositions
production
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93910928A
Other languages
German (de)
French (fr)
Other versions
EP0637915A1 (en
Inventor
Raymond A Daynes
Barbara A Araneo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
University of Utah Research Foundation UURF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation UURF filed Critical University of Utah Research Foundation UURF
Publication of EP0637915A1 publication Critical patent/EP0637915A1/en
Publication of EP0637915A4 publication Critical patent/EP0637915A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
EP93910928A 1992-05-01 1993-04-30 Compositions and methods for regulating il-6 production in vivo. Withdrawn EP0637915A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87761292A 1992-05-01 1992-05-01
US877612 1992-05-01
PCT/US1993/004067 WO1993021771A1 (en) 1992-05-01 1993-04-30 Compositions and methods for regulating il-6 production in vivo

Publications (2)

Publication Number Publication Date
EP0637915A1 EP0637915A1 (en) 1995-02-15
EP0637915A4 true EP0637915A4 (en) 1998-09-02

Family

ID=25370328

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93910928A Withdrawn EP0637915A4 (en) 1992-05-01 1993-04-30 Compositions and methods for regulating il-6 production in vivo.

Country Status (7)

Country Link
EP (1) EP0637915A4 (en)
JP (1) JPH07506372A (en)
AU (1) AU675222B2 (en)
CA (1) CA2134228A1 (en)
FI (1) FI944984A (en)
NZ (1) NZ252491A (en)
WO (1) WO1993021771A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922701A (en) * 1992-05-01 1999-07-13 University Of Utah Research Foundation Method for enhancing or accelerating re-epithelialization or re-endothelialization of a tissue
US5407927A (en) * 1993-04-16 1995-04-18 The Regents Of The University Of California Treatment of mild depression and restoration of IGF-I levels in aging by dehydroepiandrosterone
WO1996003993A2 (en) * 1994-08-05 1996-02-15 The Rockefeller University Modulation of thymocyte and t cell functional activity
JPH11507663A (en) * 1995-06-09 1999-07-06 イエダ リサーチ アンド デベロツプメント カンパニー リミテツド Pharmaceutical compositions comprising restrictin P / activin A and their use as antagonists of IL-6 and / or IL-11
US5736537A (en) * 1995-09-12 1998-04-07 Estee Lauder, Inc. Dehydroep:androsterone sailcylate useful against skin atrophy
DE19536223A1 (en) * 1995-09-28 1997-04-03 Dystar Textilfarben Gmbh & Co Process for dyeing synthetic polyamide fiber materials
JP4776145B2 (en) 2000-10-25 2011-09-21 中外製薬株式会社 Prophylactic or therapeutic agent for psoriasis containing an IL-6 antagonist as an active ingredient

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956355A (en) * 1987-04-16 1990-09-11 Colthurst Limited Agents for the arrest and therapy of retroviral infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628052A (en) * 1985-05-28 1986-12-09 Peat Raymond F Pharmaceutical compositions containing dehydroepiandrosterone and other anesthetic steroids in the treatment of arthritis and other joint disabilities
US5077284A (en) * 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956355A (en) * 1987-04-16 1990-09-11 Colthurst Limited Agents for the arrest and therapy of retroviral infections

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MEIKLE ET AL: "Adrenal androgen secretion and biologic effects", ENDOCCRINOL METAB CLIN NORTH AM, vol. 20, no. 2, 1991, pages 381 - 400, XP002068720 *
See also references of WO9321771A1 *

Also Published As

Publication number Publication date
NZ252491A (en) 1997-05-26
CA2134228A1 (en) 1993-11-11
AU675222B2 (en) 1997-01-30
EP0637915A1 (en) 1995-02-15
JPH07506372A (en) 1995-07-13
WO1993021771A1 (en) 1993-11-11
FI944984A (en) 1994-11-16
FI944984A0 (en) 1994-10-24
AU4225193A (en) 1993-11-29

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Legal Events

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Effective date: 19980930