EP0637296A4 - Non-steroid progesterone receptor agonist and antagonist compounds and methods. - Google Patents

Non-steroid progesterone receptor agonist and antagonist compounds and methods.

Info

Publication number
EP0637296A4
EP0637296A4 EP93910811A EP93910811A EP0637296A4 EP 0637296 A4 EP0637296 A4 EP 0637296A4 EP 93910811 A EP93910811 A EP 93910811A EP 93910811 A EP93910811 A EP 93910811A EP 0637296 A4 EP0637296 A4 EP 0637296A4
Authority
EP
European Patent Office
Prior art keywords
methods
receptor agonist
progesterone receptor
antagonist compounds
steroid progesterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93910811A
Other languages
German (de)
French (fr)
Other versions
EP0637296A1 (en
Inventor
I Charles Pathirana
Tina S Berger
Robert S Stein
William Fenical
Todd K Jones
Lawrence G Hamann
Luc Farmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Ligand Pharmaceuticals Inc
Original Assignee
University of California
Ligand Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, Ligand Pharmaceuticals Inc filed Critical University of California
Publication of EP0637296A1 publication Critical patent/EP0637296A1/en
Publication of EP0637296A4 publication Critical patent/EP0637296A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/24—Halogenated aromatic hydrocarbons with unsaturated side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/603—Unsaturated compounds containing a keto groups being part of a ring of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
EP93910811A 1992-04-21 1993-04-21 Non-steroid progesterone receptor agonist and antagonist compounds and methods. Withdrawn EP0637296A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87271092A 1992-04-21 1992-04-21
US872710 1992-04-21
US4864693A 1993-04-16 1993-04-16
US48646 1993-04-16
PCT/US1993/003909 WO1993021145A1 (en) 1992-04-21 1993-04-21 Non-steroid progesterone receptor agonist and antagonist compounds and methods

Publications (2)

Publication Number Publication Date
EP0637296A1 EP0637296A1 (en) 1995-02-08
EP0637296A4 true EP0637296A4 (en) 1996-02-07

Family

ID=26726365

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93910811A Withdrawn EP0637296A4 (en) 1992-04-21 1993-04-21 Non-steroid progesterone receptor agonist and antagonist compounds and methods.

Country Status (5)

Country Link
EP (1) EP0637296A4 (en)
AU (1) AU4117093A (en)
CA (1) CA2133325A1 (en)
MX (1) MX9302312A (en)
WO (1) WO1993021145A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677336A (en) * 1993-10-21 1997-10-14 Ligand Pharmaceuticals Incorporated Non-steroid androgen receptor antagonist compounds and methods
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
SG11202110742TA (en) 2019-04-02 2021-10-28 Aligos Therapeutics Inc Compounds targeting prmt5

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5134155A (en) * 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH491172A (en) * 1967-02-10 1970-05-31 Sandoz Ag Process for the preparation of anthraquinone dyes
US5135940A (en) * 1982-09-23 1992-08-04 Merck Frosst Canada, Inc. Leukotriene antagonists
JPS6287556A (en) * 1985-10-14 1987-04-22 Chisso Corp Ester compound
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
CA1340191C (en) * 1988-06-13 1998-12-15 Katsuhiro Imaki Derivatives of p-substituted phenyl ester of pivalic acid
DE3903988A1 (en) * 1989-02-10 1990-08-30 Basf Ag OXIDIZED DIPHENYLHETEROALKANES, THEIR PREPARATION AND USE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5134155A (en) * 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
C DESTABEL ET AL, JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 8, 15 April 1992 (1992-04-15), LETCHWORTH GB, pages 596 - 598 *
CHEMICAL ABSTRACTS, vol. 66, no. 21, 22 May 1967, Columbus, Ohio, US; abstract no. 94773s, A CHIRKO ET AL *
H NAGANO ET AL, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 65, no. 9, TOKYO JP, pages 2421 - 2426 *
J CHARRAVARTY ET AL, PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES,SECTION A, vol. 86A, no. 3, BANGALORE,IN, pages 317 - 325 *
J P YARDLEY ET AL, EXPERIENTIA, vol. 34, no. 9, BASEL CH, pages 1124 - 1125 *
K GUPTA, JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 42, no. 5, CALCUTTA, IN, pages 415 - 423 *
K LAUMEN ET AL, JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 1, LETCHWORTH GB, pages 49 - 51 *
K NARASAKA ET AL, CHEMISTRY LETTERS, no. 8, TOKYO JP, pages 1413 - 1416 *
K NARASAKA ET AL, TETRAHEDRON, (INCL. TETRAHEDRON REPORTS), vol. 48, no. 11, 13 March 1992 (1992-03-13), OXFORD GB, pages 2059 - 2068 *
L HARWOOD ET AL, SYNTHESIS, no. 6, STUTTGART DE, pages 476 - 480 *
M MOREAU ET AL, BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, no. 4, PARIS FR, pages 1362 - 1367 *
S ANTUS ET AL, TETRAHEDRON, (INCL. TETRAHEDRON REPORTS), vol. 42, no. 20, OXFORD GB, pages 5637 - 5640 *
S AOKI ET AL, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 110, no. 10, 11 May 1988 (1988-05-11), WASHINGTON, DC US, pages 3296 - 3298 *
S PAL ET AL, JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 22, LETCHWORTH GB, pages 1591 - 1593 *
S PAL ET AL, SYNTHESIS, no. 11, STUTTGART DE, pages 1073 - 1075 *
See also references of WO9321145A1 *
ZHURNAL ORGANISCHESKOI KHIMII, vol. 3, no. 1, pages 28 - 33 *

Also Published As

Publication number Publication date
AU4117093A (en) 1993-11-18
WO1993021145A1 (en) 1993-10-28
EP0637296A1 (en) 1995-02-08
MX9302312A (en) 1994-06-30
CA2133325A1 (en) 1993-10-28

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