EP0604453A4 - Disease associated b-cell epitopes of tpo and use thereof. - Google Patents

Disease associated b-cell epitopes of tpo and use thereof.

Info

Publication number
EP0604453A4
EP0604453A4 EP92916802A EP92916802A EP0604453A4 EP 0604453 A4 EP0604453 A4 EP 0604453A4 EP 92916802 A EP92916802 A EP 92916802A EP 92916802 A EP92916802 A EP 92916802A EP 0604453 A4 EP0604453 A4 EP 0604453A4
Authority
EP
European Patent Office
Prior art keywords
tpo
disease associated
cell epitopes
epitopes
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92916802A
Other languages
German (de)
French (fr)
Other versions
EP0604453A1 (en
Inventor
Basil Rapoport
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nichols Institute Diagnostics
Original Assignee
Basil Rapoport
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basil Rapoport filed Critical Basil Rapoport
Publication of EP0604453A1 publication Critical patent/EP0604453A1/en
Publication of EP0604453A4 publication Critical patent/EP0604453A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP92916802A 1991-07-30 1992-07-30 Disease associated b-cell epitopes of tpo and use thereof. Withdrawn EP0604453A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73804091A 1991-07-30 1991-07-30
US738040 1991-07-30
PCT/US1992/006283 WO1993003146A1 (en) 1991-07-30 1992-07-30 Disease associated b-cell epitopes of tpo and use thereof

Publications (2)

Publication Number Publication Date
EP0604453A1 EP0604453A1 (en) 1994-07-06
EP0604453A4 true EP0604453A4 (en) 1995-01-11

Family

ID=24966322

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92916802A Withdrawn EP0604453A4 (en) 1991-07-30 1992-07-30 Disease associated b-cell epitopes of tpo and use thereof.

Country Status (7)

Country Link
EP (1) EP0604453A4 (en)
JP (1) JPH07503604A (en)
AU (1) AU2403292A (en)
CA (1) CA2113280A1 (en)
FI (1) FI940391A (en)
NO (1) NO940298D0 (en)
WO (1) WO1993003146A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07506960A (en) * 1991-08-28 1995-08-03 ニコルス・インスティチュート・ダイアグノスティクス Disease-associated human antibodies specific for human thyroid peroxidase
CN105087512A (en) * 2014-05-13 2015-11-25 苏州偲聚生物材料有限公司 Protein for detecting thyroid diseases and partial peptide of protein

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
E. ZANELLI ET AL.: "Use of recombinant epitopes to study the heterogeneous nature of the autoantibodies against thyroid peroxidase in autoimmune thyroid disease", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 87, no. 1, January 1992 (1992-01-01), pages 80 - 86 *
F. LIBERT ET AL.: "Thyroperoxidase, but not the thyrotropin receptor, contains sequential epitopes recognized by autoantibodies inrecombinant peptides expressed in the pUEX vector", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 73, no. 4, October 1991 (1991-10-01), pages 857 - 860 *
M. LUDGATE ET AL.: "Antibodies to human thyroid peroxidase in autoimmune thyroid disease: studies with a cloned recombinant complementary deoxyribonucleic acid epitope", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 68, no. 6, June 1989 (1989-06-01), pages 1091 - 1096 *
R. ELISEI ET AL.: "Studies with recombinant autoepitopes of thyroid peroxidase: evidence suggesting an epitope shared between the thyroid and the gastric parietal cell", AUTOIMMUNITY, vol. 8, no. 1, 1990, pages 65 - 70 *
R. FINKE ET AL.: "Determination at the molecular level of a B-cell epitope on thyroid peroxidase likely to be associated with autoimmune thyroid disease", CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 73, no. 4, October 1991 (1991-10-01), pages 919 - 921 *
REINHARD FINKE ET AL.: "Determination at the molecular level of a B-cell epitope on thyroid peroxidase", PROCEEDINGS OF THE INTERNATIONAL THYROID CONFERENCE, THE HAGUE, 4-8 FEBRUARY 1991. PROGRESS IN THYROID RESEARCH., February 1991 (1991-02-01), pages 437 - 439 *
See also references of WO9303146A1 *

Also Published As

Publication number Publication date
WO1993003146A1 (en) 1993-02-18
NO940298L (en) 1994-01-27
FI940391A (en) 1994-03-28
FI940391A0 (en) 1994-01-26
CA2113280A1 (en) 1993-02-18
JPH07503604A (en) 1995-04-20
NO940298D0 (en) 1994-01-27
EP0604453A1 (en) 1994-07-06
AU2403292A (en) 1993-03-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19940228

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NICHOLS INSTITUTE DIAGNOSTICS

RHK1 Main classification (correction)

Ipc: C12N 15/53

A4 Supplementary search report drawn up and despatched

Effective date: 19941123

AK Designated contracting states

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STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 19960201