EP0598837A4 - Amino acid, ester and/or catechol contrast agents for mri. - Google Patents

Amino acid, ester and/or catechol contrast agents for mri.

Info

Publication number
EP0598837A4
EP0598837A4 EP19920918470 EP92918470A EP0598837A4 EP 0598837 A4 EP0598837 A4 EP 0598837A4 EP 19920918470 EP19920918470 EP 19920918470 EP 92918470 A EP92918470 A EP 92918470A EP 0598837 A4 EP0598837 A4 EP 0598837A4
Authority
EP
European Patent Office
Prior art keywords
catechol
mri
ester
amino acid
contrast agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920918470
Other versions
EP0598837A1 (en
Inventor
David L White
Robert G Eason
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of EP0598837A1 publication Critical patent/EP0598837A1/en
Publication of EP0598837A4 publication Critical patent/EP0598837A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
EP19920918470 1991-08-09 1992-08-07 Amino acid, ester and/or catechol contrast agents for mri. Withdrawn EP0598837A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74314391A 1991-08-09 1991-08-09
US743143 1991-08-09
US74447091A 1991-08-12 1991-08-12
US744470 1991-08-12
PCT/US1992/006660 WO1993003351A1 (en) 1991-08-09 1992-08-07 Amino acid, ester and/or catechol contrast agents for mri

Publications (2)

Publication Number Publication Date
EP0598837A1 EP0598837A1 (en) 1994-06-01
EP0598837A4 true EP0598837A4 (en) 1994-07-13

Family

ID=27114106

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920918470 Withdrawn EP0598837A4 (en) 1991-08-09 1992-08-07 Amino acid, ester and/or catechol contrast agents for mri.

Country Status (4)

Country Link
EP (1) EP0598837A4 (en)
JP (1) JPH07502725A (en)
CA (1) CA2115275A1 (en)
WO (1) WO1993003351A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2108269T5 (en) * 1992-07-03 2001-09-01 Welfide Corp NEW COMPLAINANT AGENT, COMPLEX COMPOSITE CONSTITUTED BY SUCH AGENT AND A METAL ATOM, AND DIAGNOSTIC AGENT CONTAINING SUCH COMPOUND.
TW319763B (en) 1995-02-01 1997-11-11 Epix Medical Inc
US20030113267A1 (en) * 1999-12-29 2003-06-19 Knopp Michael V. Colon contrast enhanced imaging
EP1369134A1 (en) 2002-06-05 2003-12-10 Bracco Imaging S.p.A. New agents for magnetic imaging method

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA705293B (en) * 1970-07-31 1971-04-28 Stauffer Chemical Co Ethylenediaminetetraacetic acid derivatives and their preparation
DE2511891A1 (en) * 1975-03-19 1976-10-07 Gruenenthal Chemie Anti-thrombotic dioxo-piperazine derivs - prepd. e.g. by cyclising N,N,N',N'-1,2-alkylene-diamine-tetraacetic acids with amines
FR2590484A1 (en) * 1983-01-21 1987-05-29 Schering Ag PHYSIOLOGICALLY ACCEPTABLE METAL COMPLEX SALTS USEFUL FOR NMR DIAGNOSIS
EP0413405A2 (en) * 1989-08-16 1991-02-20 Schering Aktiengesellschaft Use of amide complex compounds
EP0419387A1 (en) * 1989-09-21 1991-03-27 IMMUNOTECH PARTNERS: Société en Commandite par Actions dite Hydrophilic derivatives, diagnostic and therapeutic applications, kits and immunological reagents
WO1992011232A1 (en) * 1990-12-21 1992-07-09 Nycomed Imaging As Chelating agents
US5135737A (en) * 1986-11-10 1992-08-04 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for enhancement of diagnosis and therapy
WO1993000931A1 (en) * 1991-07-02 1993-01-21 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2394230A (en) * 1941-09-19 1946-02-05 John H Billman Methods of preparing alpha-amino acids and nu-substituted-alpha-amino acids
IL34615A (en) * 1969-06-11 1974-11-29 Stauffer Chemical Co Ethylenediaminetetraacetic acid derivatives and their preparation
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
CA2069886A1 (en) * 1989-10-23 1991-04-24 David Love Multi-site metal chelating agents
US9206660B2 (en) 2010-03-19 2015-12-08 Noetic Technologies Inc. Casing fill-up fluid management tool

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA705293B (en) * 1970-07-31 1971-04-28 Stauffer Chemical Co Ethylenediaminetetraacetic acid derivatives and their preparation
DE2511891A1 (en) * 1975-03-19 1976-10-07 Gruenenthal Chemie Anti-thrombotic dioxo-piperazine derivs - prepd. e.g. by cyclising N,N,N',N'-1,2-alkylene-diamine-tetraacetic acids with amines
FR2590484A1 (en) * 1983-01-21 1987-05-29 Schering Ag PHYSIOLOGICALLY ACCEPTABLE METAL COMPLEX SALTS USEFUL FOR NMR DIAGNOSIS
US5135737A (en) * 1986-11-10 1992-08-04 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for enhancement of diagnosis and therapy
EP0413405A2 (en) * 1989-08-16 1991-02-20 Schering Aktiengesellschaft Use of amide complex compounds
EP0419387A1 (en) * 1989-09-21 1991-03-27 IMMUNOTECH PARTNERS: Société en Commandite par Actions dite Hydrophilic derivatives, diagnostic and therapeutic applications, kits and immunological reagents
WO1992011232A1 (en) * 1990-12-21 1992-07-09 Nycomed Imaging As Chelating agents
WO1993000931A1 (en) * 1991-07-02 1993-01-21 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
R.J. MOTEKAITIS ET AL.: "NEW MULTIDENTATE LIGANDS.", J AMER. CHEM. SOC., vol. 92, no. 14, 1970, pages 4223 - 4230 *
R.P. HOUGHTON ET AL.: "SYNTHESIS OF BIS(IMIDES) AND BIS(HALF AMIDES) OF NN'-ETHYLENEBIS(IMINODIACETIC ACID)", J. CHEM. SOC., PERKIN TRANS 1, vol. 11, 1982, pages 2693 - 2696 *
See also references of WO9303351A1 *
W.H. BAKKER ET AL.: "(111IN-DTAP-D-PHE)-OCTREOTIDE, A POTENTIAL RADIOPHARMACEUTICAL FOR IMAGING OF SOMATOSTATIN RECEPTOR-POSITIVE TUMORS: SYNTHESIS, RADIOLABELING AND IN VITRO VALIDATION", LIFE SCIENCES, vol. 49, no. 22, 1991, pages 1583 - 1591 *

Also Published As

Publication number Publication date
CA2115275A1 (en) 1993-02-18
JPH07502725A (en) 1995-03-23
EP0598837A1 (en) 1994-06-01
WO1993003351A1 (en) 1993-02-18

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Legal Events

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Effective date: 19970301