EP0596034A4 - Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage. - Google Patents

Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage.

Info

Publication number
EP0596034A4
EP0596034A4 EP92917747A EP92917747A EP0596034A4 EP 0596034 A4 EP0596034 A4 EP 0596034A4 EP 92917747 A EP92917747 A EP 92917747A EP 92917747 A EP92917747 A EP 92917747A EP 0596034 A4 EP0596034 A4 EP 0596034A4
Authority
EP
European Patent Office
Prior art keywords
neurotrophic factor
ciliary neurotrophic
purification
methods
peripheral nerve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92917747A
Other languages
German (de)
French (fr)
Other versions
EP0596034A1 (en
Inventor
Franklin D Collins
Deborah Russell
John R Mcdonald
Erwin Freund
Larry J Wilhelm
Duane Mach Bonam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of EP0596034A1 publication Critical patent/EP0596034A1/en
Publication of EP0596034A4 publication Critical patent/EP0596034A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP92917747A 1991-07-23 1992-07-21 Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage. Withdrawn EP0596034A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73553891A 1991-07-23 1991-07-23
US75317691A 1991-08-30 1991-08-30
PCT/US1992/006136 WO1993002206A1 (en) 1991-07-23 1992-07-21 Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage
US735538 1996-10-23
US753176 2004-01-06

Publications (2)

Publication Number Publication Date
EP0596034A1 EP0596034A1 (en) 1994-05-11
EP0596034A4 true EP0596034A4 (en) 1995-05-24

Family

ID=27112907

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92917747A Withdrawn EP0596034A4 (en) 1991-07-23 1992-07-21 Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage.

Country Status (12)

Country Link
EP (1) EP0596034A4 (en)
JP (1) JPH07500725A (en)
AU (1) AU666327B2 (en)
CA (1) CA2113815A1 (en)
FI (1) FI940302A0 (en)
HU (1) HUT67352A (en)
IE (1) IE922402A1 (en)
IL (1) IL102607A0 (en)
MX (1) MXPA92004329A (en)
NO (2) NO940194L (en)
NZ (1) NZ243691A (en)
WO (1) WO1993002206A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors
IT1288388B1 (en) 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio USE OF SUBSTANCES THAT ACTIVATE THE CNTF RECEPTOR (NEUROTROPHIC CHILI FACTOR) FOR THE PREPARATION OF DRUGS FOR THERAPY
EP1013280A4 (en) * 1998-06-10 2004-04-28 Bml Inc Skin preparations for external use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0446931A1 (en) * 1990-03-14 1991-09-18 FIDIA S.p.A. Human ciliary neuronotrophic factor, DNA sequence encoding the factor, and production of the factor by recombinant technology
WO1993010233A1 (en) * 1991-11-11 1993-05-27 Fidia S.P.A. Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US501914A (en) * 1893-07-25 Method of building engine-foundations
US5011914A (en) * 1989-01-05 1991-04-30 Collins Franklin D Purified ciliary neurotrophic factor
JPH04503811A (en) * 1989-03-15 1992-07-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Purified ciliary neurotropin factor
IE903130A1 (en) * 1989-09-15 1991-03-27 Regeneron Pharma Ciliary neurotrophic factor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0446931A1 (en) * 1990-03-14 1991-09-18 FIDIA S.p.A. Human ciliary neuronotrophic factor, DNA sequence encoding the factor, and production of the factor by recombinant technology
WO1993010233A1 (en) * 1991-11-11 1993-05-27 Fidia S.P.A. Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A. NEGRO ET AL: "Synthesis, purification, and characterization of human ciliary neurotrophic factor from E.coli", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 29, 1991, pages 251 - 260 *
G. BARBIN ET AL: "Purification of the chick eye ciliary neurothropic factor", JOURNAL OF NEUROCHEMISTRY, vol. 43, no. 5, 1984, pages 1468 - 1478 *
J. MCDONALD ET AL: "Expression and characterization of recombinant human ciliary neurotrphic factor from Escherichia coli", BIOCHIMICA BIOPHYSICA ACTA, vol. 1090, no. 1, 30 August 1991 (1991-08-30), pages 70 - 80 *
L-F LIN ET AL: "Isolation and characterization of ciliary neurotrpohic factor from rabbit sciatic nerves", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 265, no. 15, 25 May 1990 (1990-05-25), BALTIMORE US, pages 8942 - 8947 *
S. SAADAT ET AL: "Ciliary neurotrpohic factor induces cholinergic differentiation of rat sympathetic neurons in culture", JOURNAL OF CELL BIOLOGY, vol. 108, May 1989 (1989-05-01), pages 1807 - 1816 *
See also references of WO9302206A1 *

Also Published As

Publication number Publication date
MXPA92004329A (en) 2005-04-01
HU9400133D0 (en) 1994-05-30
AU666327B2 (en) 1996-02-08
HUT67352A (en) 1995-03-28
EP0596034A1 (en) 1994-05-11
AU2443292A (en) 1993-02-23
FI940302A (en) 1994-01-21
CA2113815A1 (en) 1993-02-04
IE922402A1 (en) 1993-01-27
NO940194L (en) 1994-02-08
IL102607A0 (en) 1993-01-14
JPH07500725A (en) 1995-01-26
WO1993002206A1 (en) 1993-02-04
NZ243691A (en) 1995-12-21
FI940302A0 (en) 1994-01-21
NO940194D0 (en) 1994-01-19

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19940120

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Withdrawal date: 19971121