EP0590027A4 - MUTATIONS IN MYCOBACTERIES BY INSTALLATION. - Google Patents

MUTATIONS IN MYCOBACTERIES BY INSTALLATION.

Info

Publication number
EP0590027A4
EP0590027A4 EP9292913432A EP92913432A EP0590027A4 EP 0590027 A4 EP0590027 A4 EP 0590027A4 EP 9292913432 A EP9292913432 A EP 9292913432A EP 92913432 A EP92913432 A EP 92913432A EP 0590027 A4 EP0590027 A4 EP 0590027A4
Authority
EP
European Patent Office
Prior art keywords
mycobacteria
insertional mutations
insertional
mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP9292913432A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0590027A1 (en
Inventor
William R Jacobs
Barry Bloom
Ganjam V Kalpana
Jeffrey D Cirillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albert Einstein College of Medicine
Original Assignee
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert Einstein College of Medicine filed Critical Albert Einstein College of Medicine
Priority to EP99110251A priority Critical patent/EP0972839A1/en
Publication of EP0590027A1 publication Critical patent/EP0590027A1/en
Publication of EP0590027A4 publication Critical patent/EP0590027A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
EP9292913432A 1991-06-13 1992-06-02 MUTATIONS IN MYCOBACTERIES BY INSTALLATION. Withdrawn EP0590027A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP99110251A EP0972839A1 (en) 1991-06-13 1992-06-02 Insertional mutations in mycobacteria

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US71465691A 1991-06-13 1991-06-13
US714656 1991-06-13
US80670691A 1991-12-12 1991-12-12
US806706 1991-12-12
PCT/US1992/004706 WO1992022326A1 (en) 1991-06-13 1992-06-02 Insertional mutations in mycobacteria

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP99110251A Division EP0972839A1 (en) 1991-06-13 1992-06-02 Insertional mutations in mycobacteria

Publications (2)

Publication Number Publication Date
EP0590027A1 EP0590027A1 (en) 1994-04-06
EP0590027A4 true EP0590027A4 (en) 1994-10-19

Family

ID=27109189

Family Applications (2)

Application Number Title Priority Date Filing Date
EP99110251A Withdrawn EP0972839A1 (en) 1991-06-13 1992-06-02 Insertional mutations in mycobacteria
EP9292913432A Withdrawn EP0590027A4 (en) 1991-06-13 1992-06-02 MUTATIONS IN MYCOBACTERIES BY INSTALLATION.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP99110251A Withdrawn EP0972839A1 (en) 1991-06-13 1992-06-02 Insertional mutations in mycobacteria

Country Status (7)

Country Link
EP (2) EP0972839A1 (fi)
JP (1) JPH06511145A (fi)
AU (2) AU2189392A (fi)
CA (1) CA2111217A1 (fi)
FI (1) FI935566A0 (fi)
NO (2) NO934515D0 (fi)
WO (1) WO1992022326A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566121B1 (en) 1991-06-13 2003-05-20 Albert Einstein College Of Medicine Of Yeshiva University Insertional mutations in mycobacteria
JPH09505588A (ja) 1993-11-23 1997-06-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 多くの細胞外生成物及びそれらの製造法並びに使用
US6752993B1 (en) 1993-11-23 2004-06-22 The Regents Of The University Of California Abundant extracellular product vaccines and methods for their production and use
US7300660B2 (en) 1993-11-23 2007-11-27 The Regents Of The University Of California Abundant extracellular products and methods for their production and use
WO1995032277A1 (en) * 1994-05-23 1995-11-30 Albert Einstein College Of Medicine Of Yeshiva University Insertional mutations in mycobacteria
US5843664A (en) * 1996-06-11 1998-12-01 Institut Pasteur Method of selection of allelic exchange mutants
US6013660A (en) * 1996-10-02 2000-01-11 The Regents Of The University Of California Externally targeted prophylactic and chemotherapeutic method and agents
US6221364B1 (en) * 1996-11-12 2001-04-24 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacteria auxotrophic for diaminopimelate
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
AU8296498A (en) * 1997-07-10 1999-02-08 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated
US6387694B1 (en) 1998-04-03 2002-05-14 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial isocitrate lyase gene and uses thereof
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
US20020064861A1 (en) 2000-01-11 2002-05-30 Barletta Raul G. Identification of virulence determinants
CL2007002710A1 (es) * 2007-09-20 2008-01-04 Univ Pontificia Catolica Chile Formulacion inmunogenica que confiere proteccion contra la infeccion o patologia causada por el virus respiratorio sincicial (vrs) que comprende una cepa recombinante atenuada de mycobacterium; y uso de la formulacion inmunogenica para preparar una vacuna para prevenir, tratar o atenuar infecciones del vrs.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990000594A2 (en) * 1988-07-07 1990-01-25 Whitehead Institute For Biomedical Research Recombinant mycobacterial expression vehicles and uses therefor
WO1992001783A1 (en) * 1990-07-16 1992-02-06 Albert Einstein College Of Medicine Of Yeshiva University Dna capable of site-specific integration into mycobacteria

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0681026A1 (en) * 1987-03-02 1995-11-08 Whitehead Institute For Biomedical Research Recombinant mycobacterial vaccine
ATE250133T1 (de) * 1989-06-19 2003-10-15 Whitehead Biomedical Inst Verktorvermittelte genominsertion und expression von dna in bcg

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990000594A2 (en) * 1988-07-07 1990-01-25 Whitehead Institute For Biomedical Research Recombinant mycobacterial expression vehicles and uses therefor
WO1992001783A1 (en) * 1990-07-16 1992-02-06 Albert Einstein College Of Medicine Of Yeshiva University Dna capable of site-specific integration into mycobacteria

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CARLOS MARTIN ET AL.: "Transposition of an antibiotic resistance element in mycobacteria", NATURE, vol. 345, no. 6277, 21 June 1990 (1990-06-21), LONDON GB, pages 739 - 743 *
GANJAM V. KALPANA ET AL.: "Insertional mutagenesis and illegitimate recombination in mycobacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, no. 12, 15 June 1991 (1991-06-15), WASHINGTON US, pages 5433 - 5437 *
JEFFREY D. CIRILLO ET AL.: "A novel transposon Trap for mycobacteria: Isolation and characterization of IS1096", JOURNAL OF BACTERIOLOGY, vol. 173, no. 24, December 1991 (1991-12-01), pages 7772 - 7780 *
P.M. ENGLAND ET AL.: "IS900-promoted stable integration of a foreign gene into mycobacteria", MOLECULAR MICROBIOLOGY, vol. 5, no. 8, August 1991 (1991-08-01), pages 2047 - 2052 *
See also references of WO9222326A1 *
W.R.JACOBS JR. ET AL.: "Development of BCG as a recombinant vaccine vehicle", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 155, 1990, pages 153 - 160 *
WILLIAM R. JACOBS, JR. ET AL.: "Genetic systems for mycobacteria", METHODS IN ENZYMOLOGY, vol. 204, 1991, pages 537 - 555 *

Also Published As

Publication number Publication date
CA2111217A1 (en) 1992-12-23
NO934515D0 (no) 1993-12-09
WO1992022326A1 (en) 1992-12-23
EP0590027A1 (en) 1994-04-06
EP0972839A1 (en) 2000-01-19
AU2189392A (en) 1993-01-12
FI935566A (fi) 1993-12-10
AU1635797A (en) 1997-06-12
NO934515L (no) 1994-02-02
FI935566A0 (fi) 1993-12-10
JPH06511145A (ja) 1994-12-15

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19940107

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

RHK1 Main classification (correction)

Ipc: C12N 15/74

A4 Supplementary search report drawn up and despatched

Effective date: 19940901

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

17Q First examination report despatched

Effective date: 19950714

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19991014