EP0578776A4 - Retrovirus inhibition with antisense nucleic acids complementary to packaging sequences. - Google Patents
Retrovirus inhibition with antisense nucleic acids complementary to packaging sequences.Info
- Publication number
- EP0578776A4 EP0578776A4 EP92910993A EP92910993A EP0578776A4 EP 0578776 A4 EP0578776 A4 EP 0578776A4 EP 92910993 A EP92910993 A EP 92910993A EP 92910993 A EP92910993 A EP 92910993A EP 0578776 A4 EP0578776 A4 EP 0578776A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- retrovirus
- inhibition
- antisense nucleic
- nucleic acids
- acids complementary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000000692 anti-sense effect Effects 0.000 title abstract 4
- 238000004806 packaging method and process Methods 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 241001430294 unidentified retrovirus Species 0.000 title abstract 2
- 230000000295 complement effect Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
- 108020005544 Antisense RNA Proteins 0.000 abstract 1
- 239000003184 complementary RNA Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Environmental Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68087391A | 1991-04-05 | 1991-04-05 | |
US680873 | 2000-10-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0578776A1 EP0578776A1 (en) | 1994-01-19 |
EP0578776A4 true EP0578776A4 (en) | 1995-04-12 |
Family
ID=24732881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92910993A Withdrawn EP0578776A4 (en) | 1991-04-05 | 1992-04-03 | Retrovirus inhibition with antisense nucleic acids complementary to packaging sequences. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0578776A4 (en) |
JP (1) | JPH06506599A (en) |
AU (1) | AU655279B2 (en) |
CA (1) | CA2107789A1 (en) |
WO (1) | WO1992017211A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4126484A1 (en) * | 1991-08-10 | 1993-02-11 | Bayer Ag | Anti-sense-RNA expression vectors - contain hybrid promoter sequences and viral DNA sequences i.e. HIV, in anti-sense direction, useful in prodn. of HIV-resistant cells |
DE4225094A1 (en) * | 1992-04-28 | 1993-11-04 | Frank Andreas Harald Meyer | Compsn. for gene therapy, esp. of viral infections and tumours - comprises anti-sense DNA or RNA inserted into long terminal repeat or transposable element and e.g. virus envelope as carrier |
ES2312164T3 (en) | 1992-09-25 | 2009-02-16 | Aventis Pharma S.A. | ADENOVIRUS VECTORS FOR THE TRANSFER OF STRANGE GENES IN CELLS OF THE CENTRAL NERVOUS SYSTEM, PARTICULARLY IN THE BRAIN. |
EP0598935A1 (en) * | 1992-11-24 | 1994-06-01 | Bayer Ag | Expression vectors and their use to produce HIV-resistant human cells for therapeutic use |
US5583035A (en) * | 1992-12-07 | 1996-12-10 | Bayer Aktiengesellschaft | HIV antisense expression vectors |
FR2702152B1 (en) * | 1993-03-03 | 1995-05-24 | Inst Nat Sante Rech Med | Recombinant viruses and their use in gene therapy. |
US5712384A (en) * | 1994-01-05 | 1998-01-27 | Gene Shears Pty Ltd. | Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
KR100696410B1 (en) * | 1994-01-05 | 2008-11-07 | 진 쉬어즈 피티와이., 엘티디. | Ribozymes and Retrocombination Retroviruses Having Retroviral Packaging Sequence Expression Constructs |
ATE320487T1 (en) * | 1994-01-05 | 2006-04-15 | Gene Shears Pty Ltd | RIBOZYMES AGAINST AN HIV ACT SEQUENCE |
AU2133695A (en) * | 1994-04-06 | 1995-10-30 | Sadna Joshi-Sukhwal | Inhibition of hiv-1 multiplication in mammalian cells |
US20020058636A1 (en) * | 1994-09-21 | 2002-05-16 | Geoffrey P. Symonds | Ribozymes targeting the retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
IL159637A0 (en) | 2001-07-10 | 2004-06-01 | Johnson & Johnson Res Pty Ltd | Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells |
ES2358187T3 (en) | 2001-07-10 | 2011-05-06 | JOHNSON & JOHNSON RESEARCH PTY LIMITED | PROCEDURES FOR THE GENETIC MODIFICATION OF HEMATOPOYETIC PROGENITING CELLS AND USES OF THE MODIFIED CELLS. |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4740463A (en) * | 1984-04-13 | 1988-04-26 | Massachusetts Institute Of Technology | Methods and artificial genes for antagonizing the function of an oncogene |
WO1988010311A1 (en) * | 1987-06-26 | 1988-12-29 | Syntro Corporation | Recombinant human cytomegalovirus containing foreign gene and use thereof |
WO1989008146A1 (en) * | 1988-02-26 | 1989-09-08 | Worcester Foundation For Experimental Biology | Inhibition of htlv-iii by exogenous oligonucleotides |
EP0331939A2 (en) * | 1988-02-16 | 1989-09-13 | Greatbatch Gen-Aid, Ltd | Method and compositions for conferring resistance to retroviral infection |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4757055A (en) * | 1980-11-12 | 1988-07-12 | The Johns Hopkins University | Method for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells |
-
1992
- 1992-04-03 AU AU17780/92A patent/AU655279B2/en not_active Ceased
- 1992-04-03 WO PCT/US1992/002911 patent/WO1992017211A1/en not_active Application Discontinuation
- 1992-04-03 JP JP4510048A patent/JPH06506599A/en active Pending
- 1992-04-03 CA CA002107789A patent/CA2107789A1/en not_active Abandoned
- 1992-04-03 EP EP92910993A patent/EP0578776A4/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4740463A (en) * | 1984-04-13 | 1988-04-26 | Massachusetts Institute Of Technology | Methods and artificial genes for antagonizing the function of an oncogene |
WO1988010311A1 (en) * | 1987-06-26 | 1988-12-29 | Syntro Corporation | Recombinant human cytomegalovirus containing foreign gene and use thereof |
EP0331939A2 (en) * | 1988-02-16 | 1989-09-13 | Greatbatch Gen-Aid, Ltd | Method and compositions for conferring resistance to retroviral infection |
WO1989008146A1 (en) * | 1988-02-26 | 1989-09-08 | Worcester Foundation For Experimental Biology | Inhibition of htlv-iii by exogenous oligonucleotides |
Non-Patent Citations (3)
Title |
---|
HAN L ET AL: "INHIBITION OF MOLONEY MURINE LEUKEMIA VIRUS-INDUCED LEUKEMIA IN TRANSGENIC MICE EXPRESSING ANTISENSE RNA COMPLEMENTARY TO THE RETROVIRAL PACKAGING SEQUENCES.", PROC NATL ACAD SCI U S A 88 (10). 1991. 4313-4317. * |
SANFORD, J.: "Applying the PDR principle to AIDS", J. THEOR. BIOL., vol. 130, 1988, pages 469 - 480 * |
See also references of WO9217211A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU655279B2 (en) | 1994-12-15 |
JPH06506599A (en) | 1994-07-28 |
CA2107789A1 (en) | 1992-10-06 |
AU1778092A (en) | 1992-11-02 |
WO1992017211A1 (en) | 1992-10-15 |
EP0578776A1 (en) | 1994-01-19 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19931004 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
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RHK1 | Main classification (correction) |
Ipc: C12N 15/11 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19950222 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
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17Q | First examination report despatched |
Effective date: 19990301 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 19990913 |