EP0575583A4 - Komplexe von bicyclopolyazamacrocyclo carbonsäuren ihre konjugate, verfahren zur herstellung und verwendung als radiopharmazeutika. - Google Patents

Komplexe von bicyclopolyazamacrocyclo carbonsäuren ihre konjugate, verfahren zur herstellung und verwendung als radiopharmazeutika.

Info

Publication number
EP0575583A4
EP0575583A4 EP93901383A EP93901383A EP0575583A4 EP 0575583 A4 EP0575583 A4 EP 0575583A4 EP 93901383 A EP93901383 A EP 93901383A EP 93901383 A EP93901383 A EP 93901383A EP 0575583 A4 EP0575583 A4 EP 0575583A4
Authority
EP
European Patent Office
Prior art keywords
radiopharmaceuticals
conjugates
processes
preparation
acid complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93901383A
Other languages
English (en)
French (fr)
Other versions
EP0575583A1 (de
Inventor
Garry E Kiefer
Jaime Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of EP0575583A1 publication Critical patent/EP0575583A1/de
Publication of EP0575583A4 publication Critical patent/EP0575583A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP93901383A 1991-12-10 1993-07-05 Komplexe von bicyclopolyazamacrocyclo carbonsäuren ihre konjugate, verfahren zur herstellung und verwendung als radiopharmazeutika. Withdrawn EP0575583A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80539291A 1991-12-10 1991-12-10
US805392 1991-12-10

Publications (2)

Publication Number Publication Date
EP0575583A1 EP0575583A1 (de) 1993-12-29
EP0575583A4 true EP0575583A4 (de) 1995-02-15

Family

ID=25191443

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93901383A Withdrawn EP0575583A4 (de) 1991-12-10 1993-07-05 Komplexe von bicyclopolyazamacrocyclo carbonsäuren ihre konjugate, verfahren zur herstellung und verwendung als radiopharmazeutika.

Country Status (10)

Country Link
EP (1) EP0575583A4 (de)
KR (1) KR930703331A (de)
AU (1) AU3275293A (de)
CA (1) CA2103553A1 (de)
FI (1) FI933508A (de)
HU (1) HU9302308D0 (de)
IL (1) IL104062A0 (de)
MX (1) MX9207165A (de)
WO (1) WO1993012112A1 (de)
ZA (1) ZA929578B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
EP2860260A1 (de) 2008-04-11 2015-04-15 Merrimack Pharmaceuticals, Inc. Menschliches Serumalbuminvernetzer und Konjugate davon
RU2505499C1 (ru) * 2012-10-08 2014-01-27 Юлия Алексеевна Щепочкина Сырьевая смесь для имитации природного камня

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US4940796A (en) * 1989-03-17 1990-07-10 The University Of Southern Mississippi 2,6-substituted-4-aminopyridines and their corresponding intermediates
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
CA2103553A1 (en) 1993-06-11
FI933508A (fi) 1993-08-31
HU9302308D0 (en) 1993-12-28
KR930703331A (ko) 1993-11-29
FI933508A0 (fi) 1993-08-09
WO1993012112A1 (en) 1993-06-24
EP0575583A1 (de) 1993-12-29
AU3275293A (en) 1993-07-19
ZA929578B (en) 1994-06-10
MX9207165A (es) 1993-06-01
IL104062A0 (en) 1993-05-13

Similar Documents

Publication Publication Date Title
PH31205A (en) Pharmaceutical composition.
EP0580862A4 (de) Schnellösliches festes präparat.
GR3036937T3 (en) Pharmaceutical formulations.
IL100899A0 (en) Beta-amino-alpha-hydroxycarboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL101068A0 (en) Trans-pt(iv)complexes,their preparation and pharmaceutical compositions containing them
OA09810A (en) Pharmaceutical composition.
PH31073A (en) Pharmaceutical composition and process for the preparation thereof.
IL85139A0 (en) Polymer complexes,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0599159A3 (de) a-L-Rhamnosidase zur Gewinnung von Rhamnose, ein Verfahren zur Herstellung und ihre Verwendung.
HK58595A (en) Shampoo composition.
EP0593464A4 (de) Benzoesäurederivate.
ZA929330B (en) Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives.
ZA8888B (en) Solution ibuprofen complexes,compositions and processes for preparing same
ZA916433B (en) Novel pyrrolobenzimidazoles,imidazobenzoxazinones and imidazoquinolones,process for their preparation and their use and preparations containing the compounds
ZA918381B (en) Pharmaceutical compositions.
EP0575583A4 (de) Komplexe von bicyclopolyazamacrocyclo carbonsäuren ihre konjugate, verfahren zur herstellung und verwendung als radiopharmazeutika.
IL103142A0 (en) Substituted aminopropanes,processes for their preparation,and their use
HRP930131A2 (en) Amino-ascorbic acid derivatives, process for the preparation and use thereof
AU4237493A (en) Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
ZA927369B (en) Pharmaceutical compositions.
ZA929736B (en) Benzofuranylimidazole derivatives, a process for the preparation and therapeutical compositions containing the same.
ZA928699B (en) Substituted 1,5-pentanediols and processes for the preparation thereof.
AU4239893A (en) Bicyclopolyazamacrocyclophosphonic acid complexes, a process for their preparation, and their conjugates, for use as radiopharmaceuticals
GR1002048B (en) Phenilacetic acid derivatives, process for the preparation thereof and corresponding use.
ZA911649B (en) 5-phenyl-1h-pyrazol-4-propionic acid derivatives,their preparation and their use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19930814

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19950102

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 19960131

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19960611