EP0572505A4 - Human platelet-derived growth factor receptors - Google Patents

Human platelet-derived growth factor receptors

Info

Publication number
EP0572505A4
EP0572505A4 EP92905958A EP92905958A EP0572505A4 EP 0572505 A4 EP0572505 A4 EP 0572505A4 EP 92905958 A EP92905958 A EP 92905958A EP 92905958 A EP92905958 A EP 92905958A EP 0572505 A4 EP0572505 A4 EP 0572505A4
Authority
EP
European Patent Office
Prior art keywords
growth factor
derived growth
factor receptors
human platelet
platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92905958A
Other versions
EP0572505A1 (en
Inventor
Lewis T Williams
Jaime A Escobedo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24610319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0572505(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of California filed Critical University of California
Priority to EP97201602A priority Critical patent/EP0811685A3/en
Priority to EP97201609A priority patent/EP0811686A3/en
Publication of EP0572505A1 publication Critical patent/EP0572505A1/en
Publication of EP0572505A4 publication Critical patent/EP0572505A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01137—Phosphatidylinositol 3-kinase (2.7.1.137)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP92905958A 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors Withdrawn EP0572505A4 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP97201602A EP0811685A3 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors
EP97201609A EP0811686A3 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65079491A 1991-01-31 1991-01-31
US650794 1991-01-31

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP97201609A Division EP0811686A3 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors
EP97201602A Division EP0811685A3 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors

Publications (2)

Publication Number Publication Date
EP0572505A1 EP0572505A1 (en) 1993-12-08
EP0572505A4 true EP0572505A4 (en) 1996-08-28

Family

ID=24610319

Family Applications (3)

Application Number Title Priority Date Filing Date
EP97201602A Withdrawn EP0811685A3 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors
EP97201609A Withdrawn EP0811686A3 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors
EP92905958A Withdrawn EP0572505A4 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP97201602A Withdrawn EP0811685A3 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors
EP97201609A Withdrawn EP0811686A3 (en) 1991-01-31 1992-01-31 Human platelet-derived growth factor receptors

Country Status (8)

Country Link
EP (3) EP0811685A3 (en)
JP (2) JPH06505629A (en)
AU (1) AU669328B2 (en)
CA (1) CA2101632A1 (en)
IE (1) IE920318A1 (en)
NZ (1) NZ241479A (en)
SG (1) SG54230A1 (en)
WO (1) WO1992013870A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0584082T3 (en) * 1991-01-31 2000-10-16 Univ California Domains in the extracellular region of human platelet-derived growth factor receptor polypeptides
WO1993011223A1 (en) * 1991-12-02 1993-06-10 Cor Therapeutics, Inc. Methods for production of purified soluble type b and type a human platelet-derived growth factor receptor fragments
AU5136093A (en) * 1992-09-25 1994-04-26 Warner-Lambert Company Peptide antagonists of sh2 binding and therapeutic uses thereof
EP0711341A4 (en) * 1993-07-29 2001-12-19 Cor Therapeutics Inc Receptor function assays
US5882644A (en) * 1996-03-22 1999-03-16 Protein Design Labs, Inc. Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
US6682921B1 (en) 1996-08-21 2004-01-27 New York University Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
WO1998007835A2 (en) * 1996-08-21 1998-02-26 Sugen, Inc. Crystal structures of a protein tyrosine kinase
CL2007002225A1 (en) 2006-08-03 2008-04-18 Astrazeneca Ab SPECIFIC UNION AGENT FOR A RECEIVER OF THE GROWTH FACTOR DERIVED FROM PLATES (PDGFR-ALFA); NUCLEIC ACID MOLECULA THAT CODIFIES IT; VECTOR AND CELL GUESTS THAT UNDERSTAND IT; CONJUGADO UNDERSTANDING THE AGENT; AND USE OF THE AGENT OF A
US8754195B2 (en) 2010-07-02 2014-06-17 Medimmune, Llc Antibody formulations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327369A2 (en) * 1988-02-02 1989-08-09 The Regents Of The University Of California Human plalelet-derived growth factor receptor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325224B1 (en) * 1988-01-22 1996-07-31 ZymoGenetics, Inc. Methods of producing secreted receptor analogs
DK0584082T3 (en) * 1991-01-31 2000-10-16 Univ California Domains in the extracellular region of human platelet-derived growth factor receptor polypeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327369A2 (en) * 1988-02-02 1989-08-09 The Regents Of The University Of California Human plalelet-derived growth factor receptor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ESCOBEDO J A ET AL.: "A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine", MOLECULAR AND CELLULAR BIOLOGY, vol. 11, no. 2, February 1991 (1991-02-01), WASHINGTON US, pages 1125 - 1132, XP002003834 *
KAZLAUSKAS A ET AL.: "Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase", EMBO JOURNAL, vol. 9, no. 10, 1990, EYNSHAM, OXFORD GB, pages 3279 - 3286, XP002003835 *
MORRISON D. ET AL.: "Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor", CELL, vol. 58, August 1989 (1989-08-01), NA US, pages 649 - 657, XP002003832 *
See also references of WO9213870A1 *
WILLIAMS L T: "Signal transduction by the platelet-derived growth factor receptor", SCIENCE, vol. 243, 1989, LANCASTER, PA US, pages 1564 - 1570, XP002003833 *

Also Published As

Publication number Publication date
JP3710404B2 (en) 2005-10-26
JP2002186490A (en) 2002-07-02
CA2101632A1 (en) 1992-08-01
WO1992013870A1 (en) 1992-08-20
EP0811685A3 (en) 1998-04-15
IE920318A1 (en) 1992-07-29
NZ241479A (en) 1994-09-27
EP0572505A1 (en) 1993-12-08
EP0811686A3 (en) 1998-04-15
JPH06505629A (en) 1994-06-30
EP0811685A2 (en) 1997-12-10
AU1346792A (en) 1992-09-07
AU669328B2 (en) 1996-06-06
SG54230A1 (en) 1998-11-16
EP0811686A2 (en) 1997-12-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19930713

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

RHK1 Main classification (correction)

Ipc: C12N 15/12

A4 Supplementary search report drawn up and despatched

Effective date: 19960712

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

17Q First examination report despatched

Effective date: 19961118

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19980710