EP0555379B1 - Adjustable dose dispenser - Google Patents
Adjustable dose dispenser Download PDFInfo
- Publication number
- EP0555379B1 EP0555379B1 EP92900282A EP92900282A EP0555379B1 EP 0555379 B1 EP0555379 B1 EP 0555379B1 EP 92900282 A EP92900282 A EP 92900282A EP 92900282 A EP92900282 A EP 92900282A EP 0555379 B1 EP0555379 B1 EP 0555379B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- valve
- valve stem
- liquid
- chamber
- dispenser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/525—Valves specially adapted therefor; Regulating devices for metering with means for adjusting the metered quantity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
Definitions
- the present invention relates in general to a pressurized, unit dose liquid dispenser, and it relates in particular to a new and improved pressurized liquid dispenser which emits an adjustable, premeasured dose of liquid each time the dispenser is actuated.
- One such device disclosed in GB-A-2050303 (RHEN) comprises a unit dose dispenser, comprising in combination a pressurizable reservoir having a first chamber therein for containing a supply of liquid under pressure,
- insulin can be advantageously administered in the form of a spray applied to the nasal tissues of the patient. Since the prescribed doses of insulin vary over a relatively wide range, it is not possible to use any single unit dispenser for all patients unless each actuation of the dispenser emits only a very small quantity of insulin constituting a small percentage of a prescribed dose, thereby necessitating repeated operation of the dispenser for each prescribed dose of insulin. This multiple operation of the dispenser for each dose requires that the patient accurately count the number of times the dispenser is actuated to ensure that the prescribed dose is administered. This procedure is not only unnecessarily time consuming, but it can result in the improper administration of medication to the patient.
- a dispenser which emits an adjustable, but precise, dose of insulin or other liquid upon each actuation of the dispenser.
- the adjustment should be made without the use of special tools or the like so as to permit the physician as well as the patient to easily adjust the dose to be dispensed upon each actuation of the dispenser.
- the invention is characterised in that said valve stem is rotatable and tubular, and in that means for adjusting said predetermined volume are provided, said means for adjusting said predetermined volume being mounted on said valve stem and responsive to the angular position of said valve stem to selectively adjust the predetermined volume of said liquid to be dispensed through said valve stem to said nozzle.
- a plurality of metering chambers of different volumetric capacity are provided, and these chambers are adapted to be selectively moved from an inoperative to an operative position so that only the amount of liquid in the selected metering chamber is dispensed when the valve is actuated.
- the metering chambers are mounted on the stem of the metering and dispensing valve and are arranged about the periphery of the valve stem so as to be selectively brought into the operative position opposite an elastomeric discharge member interposed between the reservoir and the selected metering chamber by rotation of the valve stem.
- the valve stem is accessible from the outside of the dispenser so as to facilitate adjustable rotation thereof.
- a unit dose liquid spray dispenser 10 may be seen to include as its principal elements a rigid outer shell 12 formed of a suitable protective material such as metal, glass or plastic, an elastomeric reservoir 14 disposed entirely within the shell 12, a combined dispensing nozzle and a dispenser actuator 16, and a dispensing valve assembly identified generally by the reference number 18.
- a liquid to be dispensed in prescribed doses fills the chamber within the reservoir 14 and is maintained under pressure by an elastomeric sleeve 20 which had been stretched during the supply of the liquid under pressure to a closed flexible plastic container 22 positioned within the sleeve 20.
- a pressurized reservoir of this general type is described in U.S. patent 4,387,833. It will be understood by those skilled in the art, however, that other types of pressurized reservoirs, such as the aerosol type, may be used for some applications in place of a pressurized elastomeric reservoir.
- the dispensing valve assembly 18 includes a generally tubular flexible member 24 having an annular mounting and sealing flange 26 at the top and a centrally disposed generally conical portion 28 which depends into the reservoir.
- a generally tubular, rigid member 30 having an annular, external flange 32 at the top and a central conical portion 34 which fits tightly within the conical portion 28 of the member 24.
- a trapezoidal shaped window 36 is provided in the conical portion 34 of the member 30 near the bottom thereof and as shown in Figs. 1 and 2 is covered by the flexible member 24.
- the parts 12, 14, 20, 24 and 30 are held together in mutually assembled relationship by means of a metallic locking cap 37 which fits over external flanges on the respective parts as shown in Figs. 1 and 2.
- An annular flange 38 at the top of the container member 22 is sealingly compressed between an annular flange 40 at the top of the elastomeric sleeve 20 and the annular flange 26 at the top of the member 24.
- a tubular valve stem 42 extends upwardly through a central opening 44 in the cap 37 into a bore 46 in the nozzle and actuator member 16.
- the cap 37 is provided with an inverted cup-like central section 48 in which a pair of sealing washers 50 and 52 are positioned in superimposed relationship in sealing engagement with the external surface of the valve stem 42.
- An external annular ridge 54 is provided on the valve stem 42 and provides a stop surface which abuts the bottom surface of the lower sealing washer 52 to prevent spurious withdrawal of the valve stem from the dispenser.
- An orifice 56 is provided in the wall of the valve stem 42 at a location so as to be sealably closed by the upper sealing washer 50 when the dispenser is in the inoperative position shown in Fig. 1. As is described in greater detail hereinafter, when the valve stem is depressed to dispense a dose of liquid through the nozzle, the liquid dose is conducted through the orifice 56 to the nozzle.
- a frustoconical metering chamber carrying member 60 is fixedly mounted on the valve stem 42 below the ridge 54 in coaxial relationship therewith.
- the external profile of the member 60 is complementary to the portion of the member 30 containing the window 36 and is provided with a plurality of parabolic recesses 62a, 62b, and 62c which open onto the top surface 64 of the member 60.
- the recesses are of different sizes and provide metering chambers of a plurality of different sizes. In the disclosed embodiment, there are four such recesses, only three of which are visible in the drawing.
- the pressure in the reservoir forces the portion of the member 24 disposed opposite the window through the window against the surface of the respective recess to expel the volume of the recess through the stem and the orifice 56 to the dispensing nozzle. It will thus be seen that the volume of the recess disposed opposite the window 36 determines the quantity of liquid which is dispensed each time the nozzle and actuator 16 is depressed.
- a rod 68 depends from the member 60 in coaxial relationship with the valve stem 42, and a resilient valve member 70 is mounted to the bottom end thereof.
- the lower end of the member 30 is inturned to provide a lip 72 which functions as an annular valve seat 72 against which the valve member 70 is compressed when the nozzle and actuator member 16 is fully depressed.
- a coil spring 74 surrounds the rod 68 and is held in compression between the lip 72 and the bottom of the member 60 to bias the valve to the inoperative position.
- the valve When the valve is in the inoperative position shown in Fig. 1, the chamber within the member 30 is in direct communication with the reservoir chamber, and liquid is thus transferred thereto filling all of the metering recesses as well as the remainder of the chamber.
- the valve member 70 When the nozzle and actuator member 16 is subsequently depressed to the position shown in Fig. 2, the valve member 70 is sealably seated against the seat 72 to seal the metering chambers from the reservoir.
- the orifice 56 in the valve stem is located below the sealing washers 50 and 52 so as to communicate the metering chambers to the nozzle.
- the pressure in the reservoir forces the flexible member into the particular recess positioned opposite the window 36 to force from the inner chamber in the member 30 an amount of liquid equal to the volume of the particular recess positioned opposite the window 36.
- a detent may be provided between the flange 76 and the cap 37 or in any other suitable location to hold the member 60 in the selected angular position.
- FIGs. 7 and 8 there is illustrated another embodiment of the invention in the form of a dispenser 100 wherein the volume of liquid which is dispensed upon each actuation of the dispenser is infinitely adjustable.
- Most of the parts of the dispenser 100 are identical to corresponding parts in the dispenser 10 shown in Figs. 1 and 2, and therefore, similar parts are identified by like reference numbers.
- a chamber volume adjusting member 102 is mounted to the valve stem 42 above the spring 74 and has an eccentric external surface 104 having a configuration which may be best understood by reference to Figs. 9 and 10. It may be seen that as the stem 42 is rotated the space between the peripheral surface of the member 102 and the window 36 in the member 30 is varied so that when the member 24 is pressed through the window 36 into engagement with the surface 102 the volume of liquid which is dispensed is also varied.
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Veterinary Medicine (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Vehicle Body Suspensions (AREA)
- Valve Device For Special Equipments (AREA)
- Confectionery (AREA)
- Medicinal Preparation (AREA)
- External Artificial Organs (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
Abstract
Description
- The present invention relates in general to a pressurized, unit dose liquid dispenser, and it relates in particular to a new and improved pressurized liquid dispenser which emits an adjustable, premeasured dose of liquid each time the dispenser is actuated.
- Devices for dispensing predetermined quantities of a pressurized liquid are described in U.S. patents 3,104,785 and 4,892,232. One such device, disclosed in GB-A-2050303 (RHEN) comprises a unit dose dispenser, comprising in combination a pressurizable reservoir having a first chamber therein for containing a supply of liquid under pressure,
- a nozzle for dispensing said liquid from said reservoir,
- a second chamber for containing a quantity of said liquid,
- a dispensing valve disposed between said second chamber and said nozzle and including a valve stem axially movable between a fill position wherein said second chamber is filled with said liquid from said first chamber and a dispensing position wherein a predetermined volume of the liquid from said second chamber is supplied to said nozzle when said valve stem is axially moved from said fill position to said dispensing position, and means for expelling said predetermined volume of liquid when said valve stem is axially moved from said fill position to said dispensing position.
- For some applications, such as in the administration of insulin, it would be desirable to permit adjustment of the dose which is dispensed upon each actuation of the dispenser.
- Recently it has been found that insulin can be advantageously administered in the form of a spray applied to the nasal tissues of the patient. Since the prescribed doses of insulin vary over a relatively wide range, it is not possible to use any single unit dispenser for all patients unless each actuation of the dispenser emits only a very small quantity of insulin constituting a small percentage of a prescribed dose, thereby necessitating repeated operation of the dispenser for each prescribed dose of insulin. This multiple operation of the dispenser for each dose requires that the patient accurately count the number of times the dispenser is actuated to ensure that the prescribed dose is administered. This procedure is not only unnecessarily time consuming, but it can result in the improper administration of medication to the patient.
- Therefore, it would be desirable to provide a dispenser which emits an adjustable, but precise, dose of insulin or other liquid upon each actuation of the dispenser. Preferably, the adjustment should be made without the use of special tools or the like so as to permit the physician as well as the patient to easily adjust the dose to be dispensed upon each actuation of the dispenser.
- According to one aspect, the invention is characterised in that said valve stem is rotatable and tubular, and in that means for adjusting said predetermined volume are provided, said means for adjusting said predetermined volume being mounted on said valve stem and responsive to the angular position of said valve stem to selectively adjust the predetermined volume of said liquid to be dispensed through said valve stem to said nozzle.
- According to a second aspect of the invention a plurality of metering chambers of different volumetric capacity are provided, and these chambers are adapted to be selectively moved from an inoperative to an operative position so that only the amount of liquid in the selected metering chamber is dispensed when the valve is actuated. In the preferred embodiment of the invention, the metering chambers are mounted on the stem of the metering and dispensing valve and are arranged about the periphery of the valve stem so as to be selectively brought into the operative position opposite an elastomeric discharge member interposed between the reservoir and the selected metering chamber by rotation of the valve stem. The valve stem is accessible from the outside of the dispenser so as to facilitate adjustable rotation thereof.
- Further objects and advantages and a better understanding of the present invention may be had by reference to the following detailed description taken in connection with the accompanying drawings wherein:
- Fig. 1 is a fragmentary, elevational view, partly in cross-section, showing the metering and dispensing valve of a unit dose dispenser embodying the present invention, the dispenser being shown in the inoperative fill position;
- Fig. 2 is a fragmentary, elevational view, partly in cross-section, of the dispenser of Fig. 1, the dispenser being shown in the operative dispensing position;
- Fig. 3 is an isometric view of an element of the dispensing valve of the dispenser of Fig. 1;
- Fig. 4 is an isometric view of a resilient dispensing member used in the dispenser of Fig. 1;
- Fig. 5 is an isometric view of the stem and metering chambers used in the dispenser of Fig. 1;
- Fig. 6 is a fragmentary elevational view of the nozzle and actuator member, and the upper portion of the container of the dispenser shown in Fig. 1;
- Fig. 7 is a fragmentary elevational view, partly in cross-section of another embodiment of the present invention which provides an infinitely adjustable unit dose dispenser;
- Fig. 8 is an isometric view of one element of the dispenser shown in Fig. 7;
- Fig. 9 is a cross-sectional view taken along the line 9-9 of Fig. 8; and
- Fig. 10 is a cross-sectional view taken along the line 10-10 of Fig. 8.
- Referring particularly to Figs. 1 and 2, a unit dose
liquid spray dispenser 10 may be seen to include as its principal elements a rigidouter shell 12 formed of a suitable protective material such as metal, glass or plastic, anelastomeric reservoir 14 disposed entirely within theshell 12, a combined dispensing nozzle and adispenser actuator 16, and a dispensing valve assembly identified generally by thereference number 18. A liquid to be dispensed in prescribed doses fills the chamber within thereservoir 14 and is maintained under pressure by anelastomeric sleeve 20 which had been stretched during the supply of the liquid under pressure to a closed flexibleplastic container 22 positioned within thesleeve 20. A pressurized reservoir of this general type is described in U.S. patent 4,387,833. It will be understood by those skilled in the art, however, that other types of pressurized reservoirs, such as the aerosol type, may be used for some applications in place of a pressurized elastomeric reservoir. - The
dispensing valve assembly 18 includes a generally tubularflexible member 24 having an annular mounting and sealingflange 26 at the top and a centrally disposed generallyconical portion 28 which depends into the reservoir. Mounted above and within themember 24 is a generally tubular,rigid member 30 having an annular,external flange 32 at the top and a centralconical portion 34 which fits tightly within theconical portion 28 of themember 24. A trapezoidalshaped window 36 is provided in theconical portion 34 of themember 30 near the bottom thereof and as shown in Figs. 1 and 2 is covered by theflexible member 24. - The
parts metallic locking cap 37 which fits over external flanges on the respective parts as shown in Figs. 1 and 2. Anannular flange 38 at the top of thecontainer member 22 is sealingly compressed between anannular flange 40 at the top of theelastomeric sleeve 20 and theannular flange 26 at the top of themember 24. - A
tubular valve stem 42 extends upwardly through acentral opening 44 in thecap 37 into abore 46 in the nozzle andactuator member 16. Thecap 37 is provided with an inverted cup-likecentral section 48 in which a pair ofsealing washers valve stem 42. An externalannular ridge 54 is provided on thevalve stem 42 and provides a stop surface which abuts the bottom surface of thelower sealing washer 52 to prevent spurious withdrawal of the valve stem from the dispenser. Anorifice 56 is provided in the wall of thevalve stem 42 at a location so as to be sealably closed by theupper sealing washer 50 when the dispenser is in the inoperative position shown in Fig. 1. As is described in greater detail hereinafter, when the valve stem is depressed to dispense a dose of liquid through the nozzle, the liquid dose is conducted through theorifice 56 to the nozzle. - With further reference to Fig. 5, a frustoconical metering
chamber carrying member 60 is fixedly mounted on thevalve stem 42 below theridge 54 in coaxial relationship therewith. The external profile of themember 60 is complementary to the portion of themember 30 containing thewindow 36 and is provided with a plurality ofparabolic recesses top surface 64 of themember 60. The recesses are of different sizes and provide metering chambers of a plurality of different sizes. In the disclosed embodiment, there are four such recesses, only three of which are visible in the drawing. When the nozzle andactuator 16 is fully depressed, themember 60 fits tightly against the inner surface of themember 30 with one of the recesses 62 directly opposite thewindow 36. The pressure in the reservoir forces the portion of themember 24 disposed opposite the window through the window against the surface of the respective recess to expel the volume of the recess through the stem and theorifice 56 to the dispensing nozzle. It will thus be seen that the volume of the recess disposed opposite thewindow 36 determines the quantity of liquid which is dispensed each time the nozzle andactuator 16 is depressed. - A
rod 68 depends from themember 60 in coaxial relationship with thevalve stem 42, and aresilient valve member 70 is mounted to the bottom end thereof. The lower end of themember 30 is inturned to provide alip 72 which functions as anannular valve seat 72 against which thevalve member 70 is compressed when the nozzle andactuator member 16 is fully depressed. Acoil spring 74 surrounds therod 68 and is held in compression between thelip 72 and the bottom of themember 60 to bias the valve to the inoperative position. - When the valve is in the inoperative position shown in Fig. 1, the chamber within the
member 30 is in direct communication with the reservoir chamber, and liquid is thus transferred thereto filling all of the metering recesses as well as the remainder of the chamber. When the nozzle andactuator member 16 is subsequently depressed to the position shown in Fig. 2, thevalve member 70 is sealably seated against theseat 72 to seal the metering chambers from the reservoir. At this same time, theorifice 56 in the valve stem is located below the sealingwashers window 36 to force from the inner chamber in themember 30 an amount of liquid equal to the volume of the particular recess positioned opposite thewindow 36. - In order to adjust the amount of volume dispensed upon each actuation of the nozzle and
actuator 16, it is merely necessary to rotate the nozzle andactuator 16 and the valve stem which is affixed thereto to one of a plurality of angular positions wherein the recesses 62 are opposite the window. Suitable indicia are provided on thecap 37 and on a dependingflange portion 76 on the nozzle andactuator member 16 to facilitate such selection. As shown in Fig. 6, areference arrow 80 aligned with the central vertical axis of thewindow 36 is provided on thecap 37, and fourarrows 82 are provided on theflange 76 at the respective locations of the vertical center lines of the metering recesses 62. If desired, a detent, not shown, may be provided between theflange 76 and thecap 37 or in any other suitable location to hold themember 60 in the selected angular position. - Referring to Figs. 7 and 8, there is illustrated another embodiment of the invention in the form of a
dispenser 100 wherein the volume of liquid which is dispensed upon each actuation of the dispenser is infinitely adjustable. Most of the parts of thedispenser 100 are identical to corresponding parts in thedispenser 10 shown in Figs. 1 and 2, and therefore, similar parts are identified by like reference numbers. - As shown, a chamber
volume adjusting member 102 is mounted to thevalve stem 42 above thespring 74 and has an eccentricexternal surface 104 having a configuration which may be best understood by reference to Figs. 9 and 10. It may be seen that as thestem 42 is rotated the space between the peripheral surface of themember 102 and thewindow 36 in themember 30 is varied so that when themember 24 is pressed through thewindow 36 into engagement with thesurface 102 the volume of liquid which is dispensed is also varied. - While the present invention has been described in connection with particular embodiments thereof, it will be understood by those skilled in the art that many changes and modifications may be made thereto without departing from the true scope and spirit of the invention. Therefore, it is intended by the appended claims to cover all such changes and modifications which come within the scope of the present invention.
Claims (9)
- A unit dose dispenser (10), comprising in combination a pressurizable reservoir (14) having a first chamber therein for containing a supply of liquid under pressure,a nozzle (16) for dispensing said liquid from said reservoir,a second chamber for containing a quantity of said liquid,a dispensing valve (18) disposed between said second chamber and said nozzle (16) and including a valve stem (42) axially movable between a fill position wherein said second chamber is filled with said liquid from said first chamber and a dispensing position wherein a predetermined volume of the liquid from said second chamber is supplied to said nozzle (16) when said valve stem (42) is axially moved from said fill position to said dispensing position, and means for expelling said predetermined volume of liquid when said valve stem (42) is axially moved from said fill position to said dispensing position;characterised in that said valve stem (42) is rotatable and tubular, and in that means (62a,62b,62c) for adjusting said predetermined volume are provided, said means for adjusting said predetermined volume being mounted on said valve stem (42) and responsive to the angular position of said valve stem to selectively adjust the predetermined volume of said liquid to be dispensed through said valve stem (42) to said nozzle (16).
- A unit dose dispense according to claim 1, wherein said second chamber has a constant volume when filled with said liquid.
- A unit dose dispenser according to claim 1 comprising spring means (74) urging said valve stem (42) to said fill position.
- A dispenser (10) for dispensing a dose of fluid in response to each actuation of said dispenser, comprisinga reservoir (14) for containing a supply of liquid under pressure,a nozzle (16) for dispensing a quantity of said liquid supplied thereto,a metering chamber mounted within said reservoir,a first valve (70) connected between said metering chamber and said reservoir (14) for communicating said metering chamber to said reservoir when said valve is in a first position and for sealing said metering chamber from said reservoir when said valve is in a second position,a second valve (56) connected between said metering chamber and said nozzle (16) when said second valve is in a first position and for sealing said metering chamber from said nozzle when said second valve is in a second position,said first and second valves being interconnected for simultaneous operation,means for expelling the liquid from the said metering chamber when said first valve (70) is in said second position and said second valve (56) is in said first position;
characterised in that the metering chamber is provided with a plurality of metering chamber recesses (62a,62b,62c), and with manually adjustable means for selecting one of said metering chamber recesses, thus allowing the dose of fluid dispensed to be adjusted. - The dispenser according to claim 4, further comprising a valve stem (42),said first and second valve means (70,56) being mounted on said valve stem (42), anda member (60) carrying said metering chamber recesses (62a,62b,62c), said member being mounted on said valve stem (42).
- The dispenser according to claim 4,
said metering chamber recesses (62a,62b,62c) being angularly positioned around said valve stem (42) whereby said metering chambers are individually selectable by rotation of said valve stem. - The dispenser according to claim 4, comprisingan imperforate flexible member (24) interposed between the one of said metering chamber recesses (62a, 62b,62c) in the selected position and said reservoir (14),said flexible member (24) being forced into the selected one of said metering chamber recesses (62a,62b, 62c) by the pressure in said reservoir (14) when said dispenser (10) is actuated.
- The dispenser according to claim 6 wherein
said member (102) is eccentric with respect to the longitudinal axis of said valve stem (42). - A dispenser as claimed in claim 1, additionally comprising a container and an actuator member mounted to said container, wherein said means (102) for adjusting said predetermined volume includes an eccentric surface (104).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US608690 | 1984-05-10 | ||
US07/608,690 US5085351A (en) | 1990-11-05 | 1990-11-05 | Adjustable dose dispenser |
PCT/US1991/007821 WO1992007777A1 (en) | 1990-11-05 | 1991-10-22 | Adjustable dose dispenser |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0555379A1 EP0555379A1 (en) | 1993-08-18 |
EP0555379A4 EP0555379A4 (en) | 1994-01-19 |
EP0555379B1 true EP0555379B1 (en) | 1997-06-11 |
Family
ID=24437598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92900282A Expired - Lifetime EP0555379B1 (en) | 1990-11-05 | 1991-10-22 | Adjustable dose dispenser |
Country Status (13)
Country | Link |
---|---|
US (1) | US5085351A (en) |
EP (1) | EP0555379B1 (en) |
JP (1) | JPH06501440A (en) |
CN (1) | CN1025488C (en) |
AT (1) | ATE154322T1 (en) |
AU (1) | AU650305B2 (en) |
BR (1) | BR9106822A (en) |
CA (1) | CA2088762A1 (en) |
DE (1) | DE69126536T2 (en) |
IE (1) | IE913845A1 (en) |
IL (1) | IL99931A0 (en) |
MX (1) | MX9101903A (en) |
WO (1) | WO1992007777A1 (en) |
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US5122412A (en) * | 1989-07-10 | 1992-06-16 | E. I. Du Pont De Nemours And Company | Polyethylene plexifilamentary film-fibril sheet |
SE9300479L (en) * | 1993-02-15 | 1994-08-16 | Torbjoern Gyllenhammar | Combined drip and spray nozzle |
DE4404565C1 (en) * | 1994-02-12 | 1995-05-18 | Wicona Bausysteme Gmbh | Heat insulating compound profile for facades, windows, doors etc. |
US5484088A (en) * | 1994-04-29 | 1996-01-16 | Martin; James H. | Presettable indexed adjustable dose dispenser |
JP2002538959A (en) * | 1999-03-12 | 2002-11-19 | グラクソ グループ リミテッド | Measuring valve |
US7497359B2 (en) * | 2002-02-07 | 2009-03-03 | 3M Innovative Properties Company | Dosing device |
US6685148B2 (en) | 2002-04-24 | 2004-02-03 | Adam Zadok | Support for hand held video camera |
US6695175B2 (en) | 2002-04-24 | 2004-02-24 | James H. Martin | Piston operated fluid dispensing device |
US6832704B2 (en) | 2002-06-17 | 2004-12-21 | Summit Packaging Systems, Inc. | Metering valve for aerosol container |
US7195414B2 (en) * | 2002-06-28 | 2007-03-27 | The Procter & Gamble Company | Pressurized dispensing package and method for using the same |
WO2004022142A1 (en) * | 2002-09-06 | 2004-03-18 | 3M Innovative Properties Company | Metering valve for a metered dose inhaler providing consistent delivery |
GB0315791D0 (en) | 2003-07-07 | 2003-08-13 | 3M Innovative Properties Co | Two component molded valve stems |
ES2305408T3 (en) * | 2002-10-26 | 2008-11-01 | James H. Martin | ADJUSTABLE DOSING VALVE FOR THE DISTRIBUTION OF PRESSURE LIQUIDS. |
US7381005B2 (en) * | 2003-06-30 | 2008-06-03 | The Procter And Gamble Company | Pressurized dispensing package and method for using the same |
KR100525455B1 (en) * | 2003-11-26 | 2005-11-04 | 쓰리애플즈코스메틱스 주식회사 | Vacuum cosmetic instrument having structure for quantitative discharge with downward nozzle head |
GB0402695D0 (en) * | 2004-02-06 | 2004-03-10 | Glaxo Group Ltd | A metering pump system |
GB0402697D0 (en) * | 2004-02-06 | 2004-03-10 | Glaxo Group Ltd | A fluid dispenser |
GB0402693D0 (en) * | 2004-02-06 | 2004-03-10 | Glaxo Group Ltd | A fluid dispenser |
GB0402694D0 (en) * | 2004-02-06 | 2004-03-10 | Glaxo Group Ltd | A fluid dispenser |
GB0402691D0 (en) * | 2004-02-06 | 2004-03-10 | Glaxo Group Ltd | A fluid dispenser |
GB0402690D0 (en) * | 2004-02-06 | 2004-03-10 | Glaxo Group Ltd | A fluid dispenser |
GB0402692D0 (en) * | 2004-02-06 | 2004-03-10 | Glaxo Group Ltd | A fluid dispenser |
US7909528B2 (en) * | 2004-06-03 | 2011-03-22 | Upwrite, Llc | Support for coating instrument |
GB0420529D0 (en) * | 2004-09-16 | 2004-10-20 | 3M Innovative Properties Co | Valve stems for metered dose dispensing valves |
US7575134B2 (en) * | 2005-03-17 | 2009-08-18 | Martin James H | Self-sealing nozzle for dispensing apparatus |
ES2738048T3 (en) * | 2007-06-08 | 2020-01-20 | Diversey Inc | Apparatus and method of dispensing fluids |
KR101040968B1 (en) | 2008-08-27 | 2011-06-16 | 주식회사 승일 | Spraying can enabling to discharge predetermined amount of gas with pouch and valve assembly thereof |
DE102008043604A1 (en) * | 2008-11-10 | 2010-05-12 | Bühler AG | Casting machine and casting machine valve |
EP2382049A2 (en) | 2008-12-29 | 2011-11-02 | Otic Pharma Ltd. | Multiple-metered dispenser |
US8802058B2 (en) | 2010-04-19 | 2014-08-12 | Gelmed, Llc | Pharmaceutical compositions and methods for administering the same |
FR2971773B1 (en) * | 2011-02-22 | 2014-04-25 | Lindal France Sas | MULTIDOSE VALVE |
EP2526924A1 (en) | 2011-05-23 | 2012-11-28 | Deva Holding Anonim Sirketi | A dose adjustable oral pump spray or aerosol spray containing rasagiline |
EP2526925A1 (en) | 2011-05-23 | 2012-11-28 | Deva Holding Anonim Sirketi | A dose adjustable oral pump spray or aerosol spray containing memantine |
US9527658B2 (en) | 2012-08-08 | 2016-12-27 | James H. Martin | Metering valve fillable through the valve |
FR3000945B1 (en) * | 2013-01-15 | 2016-02-05 | Lindal France | DOSING VALVE |
CN105416871A (en) * | 2016-01-07 | 2016-03-23 | 陈玉洁 | Adjustable spray valve |
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Publication number | Priority date | Publication date | Assignee | Title |
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US3104785A (en) * | 1963-09-24 | Metering valve for pressure packages | ||
US3055560A (en) * | 1959-05-18 | 1962-09-25 | Meshberg Philip | Metering valve assembly |
FR1325336A (en) * | 1961-06-08 | 1963-04-26 | Seary Ltd | Push-button measuring cap for use with pressurized containers |
US3221946A (en) * | 1963-09-20 | 1965-12-07 | John K Riley | Dispenser for pressurized reservoir of the aerosol variety |
US3211346A (en) * | 1964-07-15 | 1965-10-12 | Meshberg Philip | Pump-type dispenser |
FR2300950A1 (en) * | 1975-02-12 | 1976-09-10 | Valois Sa | AEROSOL TYPE DOSING VALVE |
GB2050303B (en) * | 1979-05-21 | 1983-03-02 | Rhen Beteiligung Finanz | Dispensing valve |
IT1134362B (en) * | 1980-11-19 | 1986-08-13 | Valvole Aerosol Res Italia | DOSING VALVE FOR DISPENSING LIQUIDS UNDER PRESSURE |
GB8720978D0 (en) * | 1987-09-07 | 1987-10-14 | Bespak Plc | Collapsible chamber metering valve |
US4892232A (en) * | 1988-07-25 | 1990-01-09 | Martin James H | Unit dose dispenser |
-
1990
- 1990-11-05 US US07/608,690 patent/US5085351A/en not_active Expired - Lifetime
-
1991
- 1991-10-22 CA CA002088762A patent/CA2088762A1/en not_active Abandoned
- 1991-10-22 AT AT92900282T patent/ATE154322T1/en not_active IP Right Cessation
- 1991-10-22 DE DE69126536T patent/DE69126536T2/en not_active Expired - Fee Related
- 1991-10-22 EP EP92900282A patent/EP0555379B1/en not_active Expired - Lifetime
- 1991-10-22 BR BR919106822A patent/BR9106822A/en not_active IP Right Cessation
- 1991-10-22 WO PCT/US1991/007821 patent/WO1992007777A1/en active IP Right Grant
- 1991-10-22 AU AU89425/91A patent/AU650305B2/en not_active Ceased
- 1991-10-22 JP JP4500782A patent/JPH06501440A/en active Pending
- 1991-11-01 IL IL99931A patent/IL99931A0/en not_active IP Right Cessation
- 1991-11-04 IE IE384591A patent/IE913845A1/en not_active Application Discontinuation
- 1991-11-04 MX MX9101903A patent/MX9101903A/en not_active IP Right Cessation
- 1991-11-05 CN CN91111443.2A patent/CN1025488C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0555379A4 (en) | 1994-01-19 |
DE69126536D1 (en) | 1997-07-17 |
AU650305B2 (en) | 1994-06-16 |
CN1025488C (en) | 1994-07-20 |
ATE154322T1 (en) | 1997-06-15 |
AU8942591A (en) | 1992-05-26 |
BR9106822A (en) | 1993-07-13 |
US5085351A (en) | 1992-02-04 |
CN1063462A (en) | 1992-08-12 |
IL99931A0 (en) | 1992-08-18 |
EP0555379A1 (en) | 1993-08-18 |
WO1992007777A1 (en) | 1992-05-14 |
MX9101903A (en) | 1993-07-30 |
DE69126536T2 (en) | 1998-02-05 |
CA2088762A1 (en) | 1992-05-06 |
IE913845A1 (en) | 1992-05-22 |
JPH06501440A (en) | 1994-02-17 |
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