EP0551442A4 - Self-assembling ion pair drugs - Google Patents

Self-assembling ion pair drugs

Info

Publication number
EP0551442A4
EP0551442A4 EP92901703A EP92901703A EP0551442A4 EP 0551442 A4 EP0551442 A4 EP 0551442A4 EP 92901703 A EP92901703 A EP 92901703A EP 92901703 A EP92901703 A EP 92901703A EP 0551442 A4 EP0551442 A4 EP 0551442A4
Authority
EP
European Patent Office
Prior art keywords
drugs
self
ion pair
assembling ion
assembling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92901703A
Other versions
EP0551442A1 (en
Inventor
Darryl C Rideout
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of EP0551442A1 publication Critical patent/EP0551442A1/en
Publication of EP0551442A4 publication Critical patent/EP0551442A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EP92901703A 1990-10-04 1991-10-04 Self-assembling ion pair drugs Withdrawn EP0551442A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59292690A 1990-10-04 1990-10-04
US592926 1996-01-29

Publications (2)

Publication Number Publication Date
EP0551442A1 EP0551442A1 (en) 1993-07-21
EP0551442A4 true EP0551442A4 (en) 1995-08-02

Family

ID=24372618

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92901703A Withdrawn EP0551442A4 (en) 1990-10-04 1991-10-04 Self-assembling ion pair drugs

Country Status (3)

Country Link
EP (1) EP0551442A4 (en)
JP (1) JPH06504773A (en)
WO (1) WO1992005803A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2182482C1 (en) * 2000-09-19 2002-05-20 РДИнновейшн Апс Method to obtain antitumor preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186363A1 (en) * 1984-12-10 1986-07-02 Johnson Matthey, Inc., Platinum complexes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4921973A (en) * 1984-12-10 1990-05-01 Johnson Matthey Inc. Platinum complexes and the like
US4812449A (en) * 1986-07-03 1989-03-14 Scripps Clinic And Research Foundation In situ active compound assembly
US4985416A (en) * 1989-03-13 1991-01-15 Dana Farber Cancer Institute, Inc. Platinum complexes of azodiazonium dyes as anti-tumor agents
US4946849A (en) * 1989-10-10 1990-08-07 Flow Incorporated Method for the treatment of malaria

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186363A1 (en) * 1984-12-10 1986-07-02 Johnson Matthey, Inc., Platinum complexes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHRISTMAN JE ET AL: "Study of the selective cytotoxic properties of cationic, lipophilic mitochondrial-specific compounds in gynecologic malignancies.", GYNECOL ONCOL, OCT 1990, VOL. 39 , NO. 1, PAGES 72-9, UNITED STATES *
EMMA D ET AL: "DEQUALINIUM CHLORIDE ENHANCEMENT OF CYCLOSPORIN A (CSA) AND CISPLATIN ACTIVITY AGAINST HUMAN OVARIAN TUMOR CELL LINES IN VITRO", PROC ANNU MEET AM ASSOC CANCER RES, VOL. 33, ABSTR. NO. 3225 *
RIDEOUT D ET AL: "ANTILEUKEMIC EFFECTS OF A SELF-ASSEMBLING PLATINUM COMPLEX", SIXTH INTERNATIONAL SYMPOSIUM ON PLATINUM AND OTHER METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY, AUGUST 1991. & ANTI-CANCER DRUG DES, VOL. 6, NO. 4, 1991, PAGE 330. *
RIDEOUT D ET AL: "PLATINUM DRUG DELIVERY THROUGH ION PAIR FORMATION IN VIVO", PROC ANNU MEET AM ASSOC CANCER RES, VOL. 33, ABSTR. NO. 2660 *
See also references of WO9205803A1 *

Also Published As

Publication number Publication date
EP0551442A1 (en) 1993-07-21
WO1992005803A1 (en) 1992-04-16
JPH06504773A (en) 1994-06-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19930419

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): DE FR GB

A4 Supplementary search report drawn up and despatched

Effective date: 19950615

AK Designated contracting states

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Designated state(s): DE FR GB

17Q First examination report despatched

Effective date: 19951228

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19960502